DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and ntrk2b

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001184090.2	Gene:	ntrk2b / 570240	ZFINID:	ZDB-GENE-010126-2	Length:	799	Species:	Danio rerio

Alignment Length:	476	Identity:	171/476 - (35%)
Similarity:	247/476 - (51%)	Gaps:	66/476 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 HF-QPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKM 314
            || :.|.|.|..:||..|               .|.:|   ..|||...|.|
Zfish   373 HFMRIPDVDHSGIEGVFY---------------YDTTV---SPDIPPLEDRV------------- 406

  Fly   315 EKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLN 379
                   .::::.||..||:....||::.: |..:...:             .|:|......|.:
Zfish   407 -------AVYIVVGIAGVALTGCILMLVFL-KYGRSSKF-------------GMKGSSSVISNDD 450

  Fly   380 TSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTK-PNARLEK----LEYPRG 439
            .|...|....|.|.......:...|.|    :.:|.:..:.:.:..: |.:.|:.    ....|.
Zfish   451 DSASPLHHVSNGNNTPSSSEMGPDAVI----IGMTKIPVIENPQYFRNPGSMLKSDTLVQHIKRH 511

  Fly   440 DIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNI 504
            :|:..|.||:||||:||.|....|.||||.:|||||.|| :||:..:.||.|||.||....|.:|
Zfish   512 NILLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLK-EASESGRADFHREAELLTNLQHEHI 575

  Fly   505 VRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRL--QLNELHLLQMAANIAAG 567
            |:..|||....|:.::||||..|||::||||..|.|...|..|..|  :|.:..:|.:|..||||
Zfish   576 VKFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMADGQQSLLVELTQPQMLHIAQQIAAG 640

  Fly   568 MLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYN 632
            |:||:.:.||||||||||||:.|::.|||.|||:|..:|..|||:...:..:||||||.|||:|.
Zfish   641 MVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYR 705

  Fly   633 KFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRK 697
            :|:.|||||:.|:.|||:|::..||::.|::.|||:.|.:|.||..|...|..||.||..||.|:
Zfish   706 RFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQRE 770

  Fly   698 PSERPGFAEINHCIQHSIAES 718
            |..|....||::.:| |:|::
Zfish   771 PYMRLNIKEIHNLLQ-SLAKA 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308
		KR	217..299	CDD:214527	13/48 (27%)
		PTKc_Musk	435..713	CDD:133181	134/279 (48%)
		Pkinase_Tyr	441..707	CDD:285015	131/267 (49%)
ntrk2b	NP_001184090.2	leucine-rich repeat	62..86	CDD:275378
		LRR_8	85..144	CDD:290566
		leucine-rich repeat	87..110	CDD:275378
		leucine-rich repeat	111..133	CDD:275378
		IG_like	194..279	CDD:214653
		Ig	205..275	CDD:143165
		Ig_TrkB_d5	297..375	CDD:143263	1/1 (100%)
		PTKc_TrkB	507..796	CDD:270675	137/286 (48%)
		Pkinase_Tyr	513..784	CDD:285015	133/271 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910