DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and ror1

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_005165942.1	Gene:	ror1 / 568282	ZFINID:	ZDB-GENE-030131-6104	Length:	950	Species:	Danio rerio

Alignment Length:	656	Identity:	220/656 - (33%)
Similarity:	337/656 - (51%)	Gaps:	88/656 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELI---SDLTGLCREAAEKML 126
            :|.|:|.||.|..|..::..:..:.......|....|:|.|.  .:|   :.|:..|.:.|...|
Zfish   173 DEEGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAF--TMIGTSNHLSDRCSQFAIPSL 235

  Fly   127 CAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLP 191
            |.:|||.|....|......||.::|:......|..::::...    |..|..|  .:||.|..|
Zfish   236 CHFAFPTCDRSSGMDKPRDLCKDECEILENDLCKTEYIIARS----NPLILKR--LKLPKCEDL- 293

  Fly   192 HYNASMRRP---NCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQ 253
               |::..|   ||..||:...:....|:.|.|.:|..|.||::|:|||..||.|::||||.|..
Zfish   294 ---ATLDSPEAANCMRIGIPIAETINKSHKCYNNSGSDYRGTVSVTKSGRQCQPWNSQYPHSHTF 355

  Fly   254 PPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFF 318
            ..:.:.:|..|.:||||.|.:...|||:|:||:||.:.||||.|         ||  |.......
Zfish   356 LAMRYPELNGGHSYCRNPGNKHDAPWCFTLDEAVRMELCDIPPC---------DL--PKHGSSSN 409

  Fly   319 TPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRE 383
            :..::::|     |..|.:.|.|.|::...               |.        |..|...||.
Zfish   410 SMGILYIL-----VPSVAIPLAIALLFFFI---------------CV--------CRNNQKASRP 446

  Fly   384 TLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLG 448
            .              ..|....:....|.::.:|      ..||.::.::|  |...:.::..||
Zfish   447 P--------------APRQPKPVRGQNVEMSMLT------AYKPKSKAKEL--PLSAVRFMEELG 489

  Fly   449 QGAFGRVFQAR--APGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVC 511
            :.|||::::..  .||:...|   |||:|.|||.:|.|...||::||.:|||..|||:|.||||.
Zfish   490 ESAFGKIYKGHLYLPGMEHAQ---LVAIKTLKDISSAQHWGDFQQEASVLAELHHPNVVCLLGVV 551

  Fly   512 ALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD----RLQLNELHLLQMAANIAAGMLYLS 572
            ...:|:|:|||::|.|||.|||...||::.....:.:    :..|:....|.:|..:||||.||:
Zfish   552 TQEQPVCMLFEFLAQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHLAIQVAAGMEYLA 616

  Fly   573 ERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLE 637
            ...|:|:|||.||.|:.|.:.:||:|.|||.:||..|||:...|..:||||||.|:|:|.|:|.:
Zfish   617 SHFFIHKDLAARNILVGEQLHIKISDLGLSREIYSSDYYRVQPNTLLPIRWMPPEAIVYGKYSTD 681

  Fly   638 SDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERP 702
            |||||:|:.|||:|||.||||:|.:::||::.:::..:|.||::.|..:||||..||...|:.||
Zfish   682 SDVWAFGVVLWEIFSFGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRMYALMTECWQEGPARRP 746

  Fly   703 GFAEIN 708
            .|.:|:
Zfish   747 RFKDIH 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	38/150 (25%)
		KR	217..299	CDD:214527	38/81 (47%)
		PTKc_Musk	435..713	CDD:133181	122/280 (44%)
		Pkinase_Tyr	441..707	CDD:285015	120/271 (44%)
ror1	XP_005165942.1	I-set	69..154	CDD:254352
		Ig	81..149	CDD:143165
		CRD_TK_ROR1	174..315	CDD:143576	39/152 (26%)
		KR	319..400	CDD:214527	38/89 (43%)
		PTKc_Ror1	476..758	CDD:270672	123/282 (44%)
		Pkinase_Tyr	482..755	CDD:285015	121/274 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820