DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and ror2

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001015834.1	Gene:	ror2 / 548551	XenbaseID:	XB-GENE-491498	Length:	930	Species:	Xenopus tropicalis

Alignment Length:	681	Identity:	203/681 - (29%)
Similarity:	311/681 - (45%)	Gaps:	94/681 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LFASATHANSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWK 98
            ||......||.|    |.|:..:.:        :|:|.||.|..|..::..:..|.......|..
Frog   148 LFVRLGPTNSPN----PNTQDDYHK--------DGFCQPYRGIACARFIGNRTIYVDSLQMQGEI 200

  Fly    99 NEQVTTALWDELISDLTGL---CREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCY 160
            ..::|.|.  .:|...|.|   |.:.|....|.:.||.|..:..:  ...||.::|:......|.
Frog   201 ENRITAAF--TMIGTSTHLSDQCSQFAIPSFCHFVFPLCDDQTSK--PRELCRDECEVLENDLCR 261

  Fly   161 NDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGR 225
            .::.:...    |..|..:.|  ||||..|| ...|....||..||:...|.:... .|.||.|.
Frog   262 QEYNIARS----NPLILMQLH--LPNCEELP-LPESPEAANCMRIGIPVEKLNRYQ-QCYNGTGT 318

  Fly   226 FYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQ 290
            .|.|::.|:|||..||.|..|.||.|........::..|..||||.||:...|||:|:::.||.:
Frog   319 DYRGSVIVTKSGHQCQPWSNQVPHSHSLSSADHPEIGGGHAYCRNPGGQMEGPWCFTLNKHVRME 383

  Fly   291 HCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQ 355
            .||||.|      ...| ||.:::.....||          :||..:......:..:.::|   |
Frog   384 LCDIPAC------RTRD-NTKMEILYILVPS----------IAIPLVIACFFFLVCMCRNK---Q 428

  Fly   356 PAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVS 420
            .|.|:|.:                 .|:.:........:......:....:..  :.|:||.
Frog   429 KASASTPQ-----------------RRQLMASPSQDMEMPLMNQHKQQPKVKE--INLSTVR--- 471

  Fly   421 DAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQM 485
                                  ::..||:..||:|::....|..|.::...||:|.|||.....:
Frog   472 ----------------------FMEELGEDRFGKVYKGHLFGTTPGEQTQTVAIKTLKDKVEVAL 514

  Fly   486 QMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRL 550
            :.:|:.||.:.:...|||||.|:|.....:||.::|.|....||.|||...||::...:...|:.
Frog   515 REEFKHEAMMRSRLQHPNIVCLIGTVTKEQPMSMVFSYSPLSDLHEFLVMRSPHSDVGSTDDDKT 579

  Fly   551 ---QLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYK 612
               .|.....|.:...|||||.:||....||:|||.||.|:.:.::|||:|.||..::|..||||
Frog   580 VKSTLEPTDFLHIVTQIAAGMEFLSSHHVVHKDLAARNVLVFDKLSVKISDLGLFREVYAADYYK 644

  Fly   613 GDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLG 677
            ...|..:|||||..|:|.|.|.|::||:|:||:.|||:||:.||||.|.::::||:.::...||.
Frog   645 LMGNSMLPIRWMSPEAITYGKCSVDSDIWSYGVLLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLL 709

  Fly   678 CPDNTPLSVYALMRRCWNRKPSERPGFAEIN 708
            |||:.|..:|.||..||:..|:.||.|.:|:
Frog   710 CPDDCPAWIYTLMLECWSEFPARRPRFKDIH 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	37/147 (25%)
		KR	217..299	CDD:214527	35/81 (43%)
		PTKc_Musk	435..713	CDD:133181	107/277 (39%)
		Pkinase_Tyr	441..707	CDD:285015	106/268 (40%)
ror2	NP_001015834.1	I-set	62..150	CDD:369462	1/1 (100%)
		CRD_TK_ROR2	168..305	CDD:143577	37/155 (24%)
		KR	310..390	CDD:214527	34/80 (43%)
		PKc_like	463..746	CDD:389743	110/305 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920