DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and Alk

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	140/449 - (31%)
Similarity:	214/449 - (47%)	Gaps:	61/449 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 CYTVDESVRWQHCDIPMCPD-----YVDPNAVDLNTPIKMEKF-FTPSMIFLLAGIGFVAIVTLH 338
            |..:||......|   :|||     ..:..|.::........| :..|::.:...:.|:.|..|
  Fly  1063 CVALDEFRSKVRC---ICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAAL- 1123

  Fly   339 LMILLVYKLSKHKDYSQPAGAATAECSVS---MRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTI 400
              |.::|...:.|..|:.......|..:.   :|...| ..|||......|.:|..|.
  Fly  1124 --IFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNID-DSNLNNFNPNYGCDGILNG------- 1178

  Fly   401 RSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVP 465
                  |.:..:|..|.                    |..:..|.:||:||||.|:.|.......
  Fly  1179 ------HIDVNSLPQVA--------------------RDSLQLVNALGKGAFGEVYMALYRHRDG 1217

  Fly   466 DQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLS 530
            |..::.||||.|::|...:.:.||.:||.::|:|:|||:|.|:|||...:|..::.|.:|.|||.
  Fly  1218 DAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQ 1282

  Fly   531 EFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEH---M 592
            :|||     .....|.:..| |....||..|.::|.|..|:..::|:|||:|.||||::..   .
  Fly  1283 KFLR-----ENRNTPERPSL-LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGR 1341

  Fly   593 AVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQP 657
            .|||||||:|..||..|||:......:||:|||.|:.|...|:.::|||::||.||||||....|
  Fly  1342 VVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSP 1406

  Fly   658 YFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIA 716
            |.|..:.:|::.:..|..||.|...|:|:|.:|..|||..|.:||.|..:   ::|..|
  Fly  1407 YPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITL---LEHLTA 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308
		KR	217..299	CDD:214527	5/18 (28%)
		PTKc_Musk	435..713	CDD:133181	109/280 (39%)
		Pkinase_Tyr	441..707	CDD:285015	108/268 (40%)
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	111/304 (37%)
		TyrKc	1193..1460	CDD:197581	108/275 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455363
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940