DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrk and ROR1

DIOPT Version :9

Sequence 1:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_005003.2 Gene:ROR1 / 4919 HGNCID:10256 Length:937 Species:Homo sapiens


Alignment Length:660 Identity:225/660 - (34%)
Similarity:328/660 - (49%) Gaps:93/660 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 EREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELI---SDLTGLCREAAEK 124
            |.||:|:|.||.|..|..::..:..|.......|....|:|.|.  .:|   |.|:..|.:.|..
Human   163 EYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAF--TMIGTSSHLSDKCSQFAIP 225

  Fly   125 MLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSS 189
            .||.||||.|...........||.::|:......|..:::....    |..|..|  .:||||..
Human   226 SLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARS----NPMILMR--LKLPNCED 284

  Fly   190 LPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQP 254
            ||. ..|....||..||:........::.|.|..|..|.||::|:|||..||.|::||||.|...
Human   285 LPQ-PESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFT 348

  Fly   255 PLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFT 319
            .|.|.:|..|.:||||.|.::..|||:|:||:.:...||||.|      ::.|.....|||    
Human   349 ALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC------DSKDSKEKNKME---- 403

  Fly   320 PSMIFLLAGIGFVAIVTLHLMILLVYKL-----SKHKDYSQPAGAATAECSVSMRGGGDCGGNLN 379
              ::::|     |..|.:.|.|.|::..     :..|..|.|.                    ..
Human   404 --ILYIL-----VPSVAIPLAIALLFFFICVCRNNQKSSSAPV--------------------QR 441

  Fly   380 TSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYV 444
            ..:...|.|                            ..:|.....||.::.::|  |...:.::
Human   442 QPKHVRGQN----------------------------VEMSMLNAYKPKSKAKEL--PLSAVRFM 476

  Fly   445 RSLGQGAFGRVFQAR--APGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRL 507
            ..||:.|||::::..  .||:...|   |||:|.|||..:.|...:|::||.|:||..|||||.|
Human   477 EELGECAFGKIYKGHLYLPGMDHAQ---LVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCL 538

  Fly   508 LGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD----RLQLNELHLLQMAANIAAGM 568
            ||.....:|:|:||||:..|||.|||...||::.....:.:    :..|:....|.:|..|||||
Human   539 LGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGM 603

  Fly   569 LYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNK 633
            .|||...|||:|||.||.||.|.:.|||:|.|||.:||..|||:......:||||||.|:|:|.|
Human   604 EYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGK 668

  Fly   634 FSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKP 698
            ||.:||:|::|:.|||:|||.||||:|.:::|||:.:::..:|.|.::.|..:|:||..|||..|
Human   669 FSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIP 733

  Fly   699 SERPGFAEIN 708
            |.||.|.:|:
Human   734 SRRPRFKDIH 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrkNP_477255.1 CRD_FZ 67..212 CDD:295308 41/147 (28%)
KR 217..299 CDD:214527 38/81 (47%)
PTKc_Musk 435..713 CDD:133181 124/280 (44%)
Pkinase_Tyr 441..707 CDD:285015 122/271 (45%)
ROR1NP_005003.2 IG_like 66..148 CDD:214653
CRD_TK_ROR1 166..307 CDD:143576 42/149 (28%)
KR 311..393 CDD:214527 38/87 (44%)
PTKc_Ror1 467..749 CDD:270672 125/282 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..779
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 833..890
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 90 1.000 Domainoid score I7777
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222671at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

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