DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrk and NTRK1

DIOPT Version :10

Sequence 1:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_002520.2 Gene:NTRK1 / 4914 HGNCID:8031 Length:796 Species:Homo sapiens


Alignment Length:683 Identity:205/683 - (30%)
Similarity:307/683 - (44%) Gaps:139/683 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 WDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRA------VKAPLCFED--------CQATHLQ 157
            |:|     .||.....:|:.|....|..||.....      |:.|....|        ||.....
Human   162 WEE-----EGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRG 221

  Fly   158 FCYNDWVLIEEKKERNMFIKSRGHFRLPNCS-SLPHYNASMRRPNCSYIGLTELKESEVSYDCRN 221
            .....|:|.|.::...: :||.|   ||:.. :|.:..:.:.|.|.:.....::..:|||...  
Human   222 LEQAGWILTELEQSATV-MKSGG---LPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQV-- 280

  Fly   222 GNGRF--------------YMGTMNVSKSGIPCQRW--------DTQYPHKHFQPPLVFHQLLEG 264
             |..|              :....:|.....|..||        :|.:....|..|.....:..|
Human   281 -NVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHG 344

  Fly   265 ------------ENY---CRNAGGEE---------PHPWCYTVDESVRWQHCDIPMCPDYVDPNA 305
                        .||   ..|..|:.         .:|:.:..::       .||:....||.|:
Human   345 CLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPED-------PIPVSFSPVDTNS 402

  Fly   306 VDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDY--SQPAGAATAECSVSM 368
            .. ..|:: :|..||..:.:..|:...|.:.|..::|::.|..:...:  ::||..|..:     
Human   403 TS-GDPVE-KKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPED----- 460

  Fly   369 RGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIR----------STATIHSNCVALTTVTNVSDAK 423
                  |..::....||||:..:.|..|...::          |.|.:|                
Human   461 ------GLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVH---------------- 503

  Fly   424 GTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMD 488
                       ...|.|||....||:||||:||.|....|:|:|:.:|||||.|| :||:..:.|
Human   504 -----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQD 556

  Fly   489 FEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD----R 549
            |:|||.||....|.:|||..|||..|||:.::||||..|||:.|||:..|.|...|..:|    .
Human   557 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP 621

  Fly   550 LQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGD 614
            |.|.:  ||.:|:.:||||:||:...||||||||||||:.:.:.|||.|||:|..||..|||:..
Human   622 LGLGQ--LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVG 684

  Fly   615 ENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCP 679
            ....:||||||.|||||.||:.|||||::|:.|||:|::..||::.|::.|.|..|.:|..|..|
Human   685 GRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP 749

  Fly   680 DNTPLSVYALMRRCWNRKPSERPGFAEINHCIQ 712
            ...|..|||:||.||.|:|.:|....:::..:|
Human   750 RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrkNP_477255.1 CRD_FZ 67..212 CDD:470581 25/119 (21%)
KR 217..299 CDD:214527 17/127 (13%)
PTKc_Musk 435..713 CDD:133181 135/282 (48%)
NTRK1NP_002520.2 leucine-rich repeat 68..92 CDD:275378
LRR 1 90..113
LRR_8 92..150 CDD:404697
leucine-rich repeat 93..116 CDD:275378
LRR 2 116..137
leucine-rich repeat 117..139 CDD:275378
leucine-rich repeat 140..152 CDD:275378
LRRCT_2 151..192 CDD:465313 9/34 (26%)
Ig_TrkABC_d4 195..282 CDD:409361 19/93 (20%)
Ig strand A 195..201 CDD:409361 1/5 (20%)
Ig strand B 210..219 CDD:409361 2/8 (25%)
Ig strand C 222..229 CDD:409361 1/6 (17%)
Ig strand C' 231..233 CDD:409361 1/1 (100%)
Ig strand D 236..243 CDD:409361 2/7 (29%)
Ig strand E 246..255 CDD:409361 1/8 (13%)
Ig strand F 262..269 CDD:409361 1/6 (17%)
Ig strand G 272..279 CDD:409361 3/6 (50%)
IgI_TrKABC_d5 285..379 CDD:409360 12/93 (13%)
Ig strand A 285..291 CDD:409360 0/5 (0%)
Ig strand A' 293..296 CDD:409360 0/2 (0%)
Ig strand B 299..307 CDD:409360 1/7 (14%)
Ig strand C 310..317 CDD:409360 3/6 (50%)
Ig strand C' 320..323 CDD:409360 0/2 (0%)
Ig strand D 328..334 CDD:409360 1/5 (20%)
Ig strand E 341..349 CDD:409360 1/7 (14%)
Ig strand F 357..365 CDD:409360 2/7 (29%)
Ig strand G 368..376 CDD:409360 1/7 (14%)
Interaction with SQSTM1. /evidence=ECO:0000250 469..490 6/20 (30%)
PTKc_TrkA 504..783 CDD:270674 135/282 (48%)
DXXLL. /evidence=ECO:0000269|PubMed:26446845 537..541 0/3 (0%)
DXXLL. /evidence=ECO:0000269|PubMed:26446845 607..611 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.