DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrk and MUSK

DIOPT Version :9

Sequence 1:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster
Sequence 2:XP_005252051.1 Gene:MUSK / 4593 HGNCID:7525 Length:879 Species:Homo sapiens


Alignment Length:693 Identity:265/693 - (38%)
Similarity:346/693 - (49%) Gaps:175/693 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 EREENGYCAPYSGKVCKEYLTGQVWY----SLEDPTGGWKNEQVTTALWDELISDLTGLCREAAE 123
            :::..||||.|.|:||...|......    |..||...  .|.:....|:|| ..::.:||.|||
Human   320 QKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEA--QELLVHTAWNEL-KVVSPVCRPAAE 381

  Fly   124 KMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCS 188
            .:||.:.|..| ..|......|:|.|.|.|....||..:|:::|||..|.::........:|.||
Human   382 ALLCNHIFQEC-SPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECS 445

  Fly   189 SLP--HYN--ASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPH 249
            .||  |::  |..|.|:..|                             :|..:           
Human   446 KLPSMHWDPTACARLPHLDY-----------------------------NKENL----------- 470

  Fly   250 KHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKM 314
            |.| ||:.               ..:|         ||     |||             |.|...
Human   471 KTF-PPMT---------------SSKP---------SV-----DIP-------------NLPSSS 492

  Fly   315 EKFF----TPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCG 375
            ...|    |.||..:::.:...||..| |.|..:|...:.|.:.                     
Human   493 SSSFSVSPTYSMTVIISIMSSFAIFVL-LTITTLYCCRRRKQWK--------------------- 535

  Fly   376 GNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTN--VSDAKGTKP---------NA 429
               |..||                        |..|.|||:.:  :.|.....|         |.
Human   536 ---NKKRE------------------------SAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNP 573

  Fly   430 RLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREAC 494
            :|..|||||.:|.|||.:|:||||||||||||||:|.:...:|||||||::||..||.||:|||.
Human   574 KLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 638

  Fly   495 LLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD---RLQLNE-- 554
            |:||||:||||:||||||:|:||||||||||.|||:||||:.||:........|   |.|::.  
Human   639 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPG 703

  Fly   555 ------LHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKG 613
                  ...|.:|..:||||.||||||||||||||||||:.|:|.|||||||||..||..||||.
Human   704 PPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKA 768

  Fly   614 DENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGC 678
            :|||.|||||||.|||.||:::.||||||||:.|||:||:.||||:|:.|||||.|:::||:|.|
Human   769 NENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSC 833

  Fly   679 PDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESECK 721
            |:|.|:.:|.|||.||::.|::||.|..|     |.|.|..|:
Human   834 PENCPVELYNLMRLCWSKLPADRPSFTSI-----HRILERMCE 871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrkNP_477255.1 CRD_FZ 67..212 CDD:295308 48/152 (32%)
KR 217..299 CDD:214527 11/81 (14%)
PTKc_Musk 435..713 CDD:133181 176/288 (61%)
Pkinase_Tyr 441..707 CDD:285015 171/276 (62%)
MUSKXP_005252051.1 I-set 28..117 CDD:254352
Ig 36..117 CDD:299845
I-set 121..203 CDD:254352
Ig 135..201 CDD:299845
I-set 223..306 CDD:254352
Ig 239..306 CDD:143165
CRD_FZ 325..467 CDD:295308 48/174 (28%)
PTKc_Musk 579..868 CDD:133181 178/293 (61%)
Pkinase_Tyr 585..866 CDD:285015 173/285 (61%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158701
Domainoid 1 1.000 361 1.000 Domainoid score I963
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H4084
Inparanoid 1 1.050 454 1.000 Inparanoid score I1600
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D222671at33208
OrthoFinder 1 1.000 - - FOG0008235
OrthoInspector 1 1.000 - - oto90832
orthoMCL 1 0.900 - - OOG6_110114
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4742
SonicParanoid 1 1.000 - - X6208
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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