Protein Alignment Nrk and Abl

DIOPT Version :10

• Sequence 1: NP_477255.1
• Gene: Nrk / 36445
• FlyBaseID: FBgn0020391
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 539
• Identity: 162/539 - (30%)
• Similarity: 241/539 - (44%)
• Gaps: 108/539 - (20%)

  Fly   222 GNGRFYMGTMNVSKSGIPCQRWDTQ----YPHKHFQPPLVFHQLLE----GENYCRNAGGEEPH- 277
            |.|  :..|.:|.:|   ..||.::    .|......|.:|..|.:    |||......||:..
  Fly   175 GGG--HSSTTSVFES---AHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRI 234

  Fly   278 -------PWCYTVDES--VRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTP-----SMIFLLAG 328
                   .||....:|  |.|    :|  .:||.|    ||:..|...:..|     :...|.:|
  Fly   235 LSYNKSGEWCEAHSDSGNVGW----VP--SNYVTP----LNSLEKHSWYHGPISRNAAEYLLSSG 289

  Fly   329 IGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGG---------DCGGNLNTSRET 384
            |....:|              .:..|.|     .:.|:|:|..|         |..|.:..::|
  Fly   290 INGSFLV--------------RESESSP-----GQRSISLRYEGRVYHYRISEDPDGKVFVTQE- 334

  Fly   385 LGGNGNTNTLAKWGTIRSTATIHSNCV-----ALTTVTNVSDAKGTKP-----NARLEKLEYPRG 439
                ...||||:        .:|.:.|     .|.|.......|..||     :...::.|..|.
  Fly   335 ----AKFNTLAE--------LVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRT 387

  Fly   440 DIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNI 504
            ||:....||.|.:|.|::|     |..:....||||.||:|.  ....||..||.::.|..|||:
  Fly   388 DIMMKHKLGGGQYGEVYEA-----VWKRYGNTVAVKTLKEDT--MALKDFLEEAAIMKEMKHPNL 445

  Fly   505 VRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGML 569
            |:|:|||....|..::.|:|:.|:|.:|||:..           |..|:.:.||.||..||:||.
  Fly   446 VQLIGVCTREPPFYIITEFMSHGNLLDFLRSAG-----------RETLDAVALLYMATQIASGMS 499

  Fly   570 YLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKF 634
            ||..|.::|||||.||||:.::..||:|||||: ::...|.|........||:|...|.:.||||
  Fly   500 YLESRNYIHRDLAARNCLVGDNKLVKVADFGLA-RLMRDDTYTAHAGAKFPIKWTAPEGLAYNKF 563

  Fly   635 SLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPS 699
            |.:|||||:|:.|||:.::.:.||..:...:|...:.:|..:..|...|..||.|||:||....:
  Fly   564 STKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDAT 628

  Fly   700 ERPGFAEINHCIQHSIAES 718
            :||.|..|:|.::|...||
  Fly   629 DRPTFKSIHHALEHMFQES 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:470581
		KR	217..299	CDD:214527	22/94 (23%)
		PTKc_Musk	435..713	CDD:133181	106/277 (38%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	15/59 (25%)
		SH2_ABL	268..363	CDD:198189	23/126 (18%)
		PTKc_Abl	382..644	CDD:270645	107/280 (38%)
		FABD	1584..1723	CDD:197885