DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and Tie

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	110/396 - (27%)
Similarity:	167/396 - (42%)	Gaps:	120/396 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 EYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDL--------LVAVKMLKDDASDQMQMDFER 491
            ::.|.:|.....||:|.||:|::|.|       :||        :||||.::   :...|:..:.
  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEA-------DDLSGHFGATRIVAVKTIR---ACSAQVSLKD 902

  Fly   492 EACLLAEF-DHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPT-----QDRL 550
            ||.::.:. .|.|:|.|||.|....|..|:.||...|.|...|||... ||:..|.     :...
  Fly   903 EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARS-ATNILPASVPGGRSLA 966

  Fly   551 QLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLS------------- 602
            .|:...|...|.:||.||.|::.|:.||||||.||.|::.:...||.|||:|
  Fly   967 PLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQE 1031

  Fly   603 ------------HKI-------YLQDYYK------------------GDENDF-----------I 619
                        ||.       |:..:::                  |::...           :
  Fly  1032 KNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHAL 1096

  Fly   620 PIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPL 684
            |||||..||:.|:.|:.|:|:||:||.|||:.:....||..||..|||:.:.:|.....|..:..
  Fly  1097 PIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRH 1161

  Fly   685 SVYALMRRCWNRKPSERPGFA-------------------------------EINHCI---QHSI 715
            ..|.||.|||:::|..||.||                               ::.|.:   .|.|
  Fly  1162 EFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGVVYFNHRI 1226

  Fly   716 AESECK 721
            :|.||:
  Fly  1227 SEFECE 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308
		KR	217..299	CDD:214527
		PTKc_Musk	435..713	CDD:133181	105/386 (27%)
		Pkinase_Tyr	441..707	CDD:285015	103/371 (28%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	102/339 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	102/337 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455323
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940