DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and Ror1

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001102141.1	Gene:	Ror1 / 362550	RGDID:	1559469	Length:	937	Species:	Rattus norvegicus

Alignment Length:	657	Identity:	226/657 - (34%)
Similarity:	325/657 - (49%)	Gaps:	87/657 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELI---SDLTGLCREAAEK 124
            |.||:|:|.||.|..|..::..:..|.......|....|:|.|.  .:|   |.|:..|.:.|..
  Rat   163 EYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAF--TMIGTSSHLSDKCSQFAIP 225

  Fly   125 MLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSS 189
            .||.||||.|...........||.::|:......|:.:::....    |..|..|  .:||||..
  Rat   226 SLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCHTEYIFARS----NPMILMR--LKLPNCED 284

  Fly   190 LPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQP 254
            ||. ..|....||..||:........::.|.|..|..|.||::|:|||..||.|::||||.|...
  Rat   285 LPQ-PESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFT 348

  Fly   255 PLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFF- 318
            .|.|.:|..|.:||||.|.::..|||:|:||:.:...||||.|      ::.|.....|||..:
  Rat   349 ALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC------DSKDSKEKNKMEILYI 407

  Fly   319 -TPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSR 382
             .||:...|| |.|       |...:....:..|..|.|                       ..|
  Rat   408 LVPSVAIPLA-IAF-------LFFFICVCRNNQKSPSPP-----------------------VQR 441

  Fly   383 ETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSL 447
            :.....|..                         ..:|.....||.::.::|  |...:.::..|
  Rat   442 QPKPVRGQN-------------------------VEMSMLNAYKPKSKAKEL--PLSAVRFMEEL 479

  Fly   448 GQGAFGRVFQAR--APGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGV 510
            |:..||::::..  .||:...|   |||:|.|||..:.|...:|::||.|:||..|||||.|||.
  Rat   480 GECTFGKIYKGHLYLPGMDHAQ---LVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGA 541

  Fly   511 CALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD----RLQLNELHLLQMAANIAAGMLYL 571
            ....:|:|:|||||..|||.|||...||::.....:.:    :..|:....|.:|..|||||.||
  Rat   542 VTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYL 606

  Fly   572 SERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSL 636
            |...|||:|||.||.||.|.:.|||:|.|||.:||..|||:......:||||||.|:|:|.|||.
  Rat   607 SSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSS 671

  Fly   637 ESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSER 701
            :||:|::|:.|||:|||.||||:|.:::|||:.:::..:|.|.::.|..:|:||..|||..||.|
  Rat   672 DSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRR 736

  Fly   702 PGFAEIN 708
            |.|.:|:
  Rat   737 PRFKDIH 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	41/147 (28%)
		KR	217..299	CDD:214527	38/81 (47%)
		PTKc_Musk	435..713	CDD:133181	124/280 (44%)
		Pkinase_Tyr	441..707	CDD:285015	122/271 (45%)
Ror1	NP_001102141.1	IG_like	66..148	CDD:214653
		IGc2	72..137	CDD:197706
		CRD_TK_ROR1	166..307	CDD:143576	42/149 (28%)
		KR	311..393	CDD:214527	38/87 (44%)
		PTKc_Ror1	467..749	CDD:270672	125/282 (44%)
		Pkinase_Tyr	473..746	CDD:285015	123/274 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7587
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820