DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and musk

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001004503.1	Gene:	musk / 334526	ZFINID:	ZDB-GENE-030131-6458	Length:	941	Species:	Danio rerio

Alignment Length:	690	Identity:	291/690 - (42%)
Similarity:	383/690 - (55%)	Gaps:	116/690 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GYCAPYSGKVCKEYLTGQVW----YSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCA 128
            |||:.|.|.||:..|.....    |||.:|...  .|.:..:.|.|| ..::..||.||..:||.
Zfish   311 GYCSTYRGDVCRNVLRRDALVFFNYSLPNPEDA--QEYLAQSAWPEL-DGVSSFCRPAARSLLCH 372

  Fly   129 YAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHY 193
            ..|.:|:..|......|:|.|.|......:||.:|...||:.:|..     .|..||.|:|||..
Zfish   373 STFQDCNPSGLGPAPKPVCREHCLTVKELYCYKEWRSAEERSQRGF-----QHITLPECTSLPSQ 432

  Fly   194 NASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVF 258
            .|.  ..:|:.:...::|:.:|:..|.|..||||.||.||:.|.||||||:.|.||:|.....|.
Zfish   433 QAD--PSSCTAVPYVDIKKDQVTSTCYNDKGRFYQGTHNVTASSIPCQRWNQQDPHQHRLSVDVI 495

  Fly   259 HQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPS-- 321
            .:|...||||||.|||...|||||.:.:|||::|.:|.|.:.:........|  |...|:.|.
Zfish   496 PELRNAENYCRNPGGESDRPWCYTTNPNVRWEYCLVPKCGEVISIRTAPSIT--KPAHFYPPPSV 558

  Fly   322 --------MIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNL 378
                    :||::||....|..|  ::||:.::..|
Zfish   559 STAYSMSVIIFVIAGFAGAAFFT--VLILMCHRRKK----------------------------- 592

  Fly   379 NTSRETLGGNGNTNTLAKW----GTIRSTATIHSNCVALTTVTN--VSDAKGTKP---------N 428
                             .|    ..:..|.|       |||:.:  :.|.....|         |
Zfish   593 -----------------MWKKRKSRVLETPT-------LTTLPSELLLDRLHPNPMYQRLPLLLN 633

  Fly   429 ARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREA 493
            ::|..|||||.:|.|||.:|:||||||||||||||:|.:...:|||||||::||..||.||:|||
Zfish   634 SKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPTEPFTMVAVKMLKEEASTDMQNDFQREA 698

  Fly   494 CLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFL-RACSPYATHQAPTQDRLQLNELHL 557
            .|::|||||||||||||||:|:||||:|||||.|||:||| |.|   ||.| |:..|..|....|
Zfish   699 ALMSEFDHPNIVRLLGVCAVGKPMCLMFEYMAYGDLNEFLRRRC---ATQQ-PSLSRDTLTSSSL 759

  Fly   558 ---------------LQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYL 607
                           |.::..:||||.||||||||||||||||||:.|::.|||||||||..||.
Zfish   760 VSEPERYPPLSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAENLVVKIADFGLSRNIYA 824

  Fly   608 QDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKE 672
            .||||..|||.|||||||.|||.||:::.||||||||:.|||:||:.:|||:|:.|||||.|:::
Zfish   825 ADYYKASENDAIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRD 889

  Fly   673 GNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQ 712
            ||||.||:|.|..:|.|||.||:..|::||.||.|:..::
Zfish   890 GNVLSCPENCPQELYNLMRLCWSGHPTDRPSFASIHRILE 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	44/147 (30%)
		KR	217..299	CDD:214527	43/81 (53%)
		PTKc_Musk	435..713	CDD:133181	178/294 (61%)
		Pkinase_Tyr	441..707	CDD:285015	173/281 (62%)
musk	NP_001004503.1	I-set	26..108	CDD:254352
		Ig	37..108	CDD:299845
		IG_like	124..205	CDD:214653
		Ig	136..198	CDD:299845
		I-set	210..298	CDD:254352
		Ig	212..300	CDD:299845
		CRD_TK_ROR_related	309..449	CDD:143578	44/147 (30%)
		KR	454..536	CDD:214527	43/81 (53%)
		PTKc_Musk	640..930	CDD:133181	178/294 (61%)
		Pkinase_Tyr	646..928	CDD:285015	174/285 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	353	1.000	Domainoid score	I957
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4084
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	1	1.000	-	-		FOG0008235
OrthoInspector	1	1.000	-	-		oto39877
orthoMCL	1	0.900	-	-		OOG6_110114
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970