DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and sev

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_511114.2	Gene:	sev / 32039	FlyBaseID:	FBgn0003366	Length:	2554	Species:	Drosophila melanogaster

Alignment Length:	772	Identity:	191/772 - (24%)
Similarity:	289/772 - (37%)	Gaps:	248/772 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LCVFLFASATHANSLNAIEEPVTRRHHQRHH----EREREENGYCAPYSGKVCKEYLTGQVWYSL 90
            |.|...|:.|.:||        :.|.|.|..    |.:..|.|   |||        ....|...
  Fly  1877 LWVQAHATPTKSNS--------SERLHVRSFAELPELQLLELG---PYS--------LSLTWAGT 1922

  Fly    91 EDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATH 155
            .||.|..:.|                 ||.:||::.                      .:....|
  Fly  1923 PDPLGSLQLE-----------------CRSSAEQLR----------------------RNVAGNH 1948

  Fly   156 LQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKES------- 213
            .:      :::|..:.|..:          .|..|..|.|:...|  .|.|..|:.|:
  Fly  1949 TK------MVVEPLQPRTRY----------QCRLLLGYAATPGAP--LYHGTAEVYETLGDAPSQ 1995

  Fly   214 --------------EVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQL--L 262
                          .|::....|||                             .|:..:.|  |
  Fly  1996 PGKPQLEHIAEEVFRVTWTAARGNG-----------------------------APIALYNLEAL 2031

  Fly   263 EGENYC--------RNAGGE-EPHPWCYTVDESV----RWQHCDIPMCPDYVDPNAVDLNTPIK- 313
            :..:..        ||:||. |..||   .:|.|    :|    :..|      |..:|:..:|
  Fly  2032 QARSDIRRRRRRRRRNSGGSLEQLPW---AEEPVVVEDQW----LDFC------NTTELSCIVKS 2083

  Fly   314 ------------------------------MEKFFTPSM--IFLLAGIGFVAIV-TLHLMILLVY 345
                                          .|.|.:|..  ..:||.|...||| :..|.::||.
  Fly  2084 LHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVSSCVLALVLVR 2148

  Fly   346 KLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNT-NTLAKWGTIRSTA---TI 406
            |:.|.:..::..                    |..||.::..|.:| .|..:...:|:.|   |:
  Fly  2149 KVQKRRLRAKKL--------------------LQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTL 2193

  Fly   407 HSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLL 471
            ....:||....|.|..|                   .:|.||.||||.|::.:.. ....:|...
  Fly  2194 SDADIALLPQINWSQLK-------------------LLRFLGSGAFGEVYEGQLK-TEDSEEPQR 2238

  Fly   472 VAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRAC 536
            ||:|.|:..||:..::  .:||.|::.|.|.|||.|:|:|.....:.|:.|:|..|||..:|||.
  Fly  2239 VAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAA 2301

  Fly   537 SPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINE-------HMAV 594
            ...:|.:......|.|:|  ||.|..::|.|..||.:..|||||||.||||:.|       ...|
  Fly  2302 RATSTQEPQPTAGLSLSE--LLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTV 2364

  Fly   595 KIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYF 659
            ||.||||:..||..|||:.:....:|:|||..||::...|:.:|||||:|:..||:.:...|||.
  Fly  2365 KIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYA 2429

  Fly   660 GLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIA 716
            ...:.||:.::|||..|..|......:|:|:..||...|.|||.|....:.: |:|:
  Fly  2430 ARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL-HAIS 2485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	24/144 (17%)
		KR	217..299	CDD:214527	17/96 (18%)
		PTKc_Musk	435..713	CDD:133181	104/284 (37%)
		Pkinase_Tyr	441..707	CDD:285015	104/272 (38%)
sev	NP_511114.2	fn3	439..520	CDD:278470
		FN3	826..921	CDD:238020
		LY	993..1026	CDD:214531
		FN3	1292..1374	CDD:214495
		FN3	1799..1897	CDD:238020	8/27 (30%)
		FN3	1993..2111	CDD:238020	21/159 (13%)
		Pkinase_Tyr	2209..2481	CDD:285015	105/295 (36%)
		PTKc_c-ros	2213..2483	CDD:270640	104/275 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455277
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940