DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrk and Ror2

DIOPT Version :10

Sequence 1:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster
Sequence 2:XP_017455997.1 Gene:Ror2 / 306782 RGDID:1305275 Length:950 Species:Rattus norvegicus


Alignment Length:724 Identity:222/724 - (30%)
Similarity:338/724 - (46%) Gaps:106/724 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 VVERVLRGMVLK--WGANLAVLGL---------CVFLFASATHANSLNAIEEP------VTRRHH 56
            ||:...|.::.|  :|:.|.:..|         ||     ||  |.|..|...      :...|.
  Rat   109 VVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCV-----AT--NGLKTITATGVLYVRLGPTHS 166

  Fly    57 QRHH-EREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGL--- 117
            ..|: :.:.:|:|:|.||.|..|..::..:..|.......|....::|.|.  .:|...|.|   
  Rat   167 PNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAF--TMIGTSTHLSDQ 229

  Fly   118 CREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHF 182
            |.:.|....|.:.||.|...........||.::|:......|..::.:...    |..|..|  .
  Rat   230 CSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARS----NPLILMR--L 288

  Fly   183 RLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQY 247
            :||.|.:|| ...|....||..||:...:.... :.|.||:|..|.|..:.:|||..||.|..|:
  Rat   289 QLPKCEALP-MPESPDAANCMRIGIPAERLGRY-HQCYNGSGTDYRGMASTTKSGHQCQPWALQH 351

  Fly   248 PHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPI 312
            ||.|......|.:|..|..||||.||:...|||:|.:::||.:.||:|.|            :|.
  Rat   352 PHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRVELCDVPPC------------SPR 404

  Fly   313 KMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGN 377
            ...|.   .::::|     |..:.:.|:|..::.|.......|.|.|:|.:              
  Rat   405 DGSKM---GILYIL-----VPSIAIPLVIACLFFLVCMCRNKQKASASTPQ-------------- 447

  Fly   378 LNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIV 442
                                  .|......|..:.:..::....||       |:::..  ..:.
  Rat   448 ----------------------RRQLMASPSQDMEMPLISQHKQAK-------LKEISL--STVR 481

  Fly   443 YVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRL 507
            ::..||:..||:|::....|..|.:...:||:|.|||.|...::.:|.:||.|.|...|||||.|
  Rat   482 FMEELGEDRFGKVYKGHLFGPAPGEPTQVVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCL 546

  Fly   508 LGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELH---LLQMAANIAAGML 569
            |||....:|:.::|.|...|||.|||...||::...:...||...:.|.   .:.:.|.|||||.
  Rat   547 LGVVTKDQPLSMVFSYCCHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGME 611

  Fly   570 YLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKF 634
            :||....||:||||||.|:.:.:.|:|:|.||..::|..||||...|..:|||||..|:::|.||
  Rat   612 FLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKF 676

  Fly   635 SLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPS 699
            |::||:|:||:.||||||:.||||.|.::::|::.|:...||.|||:.|..|||||..|||..||
  Rat   677 SIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPS 741

  Fly   700 ERPGFAEIN 708
            .||.|.:|:
  Rat   742 GRPRFKDIH 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrkNP_477255.1 CRD_FZ 67..212 CDD:470581 36/147 (24%)
KR 217..299 CDD:214527 35/81 (43%)
PTKc_Musk 435..713 CDD:133181 118/277 (43%)
Ror2XP_017455997.1 I-set 71..159 CDD:400151 14/56 (25%)
Ig strand B 86..90 CDD:409353
Ig strand C 99..103 CDD:409353
Ig strand E 125..129 CDD:409353 1/3 (33%)
Ig strand F 139..144 CDD:409353 2/9 (22%)
Ig strand G 152..155 CDD:409353 0/2 (0%)
CRD_TK_ROR2 177..316 CDD:143577 37/147 (25%)
KR 321..402 CDD:214527 35/92 (38%)
Protein Kinases, catalytic domain 473..756 CDD:473864 118/280 (42%)
Blue background indicates that the domain is not in the aligned region.

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