DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrk and Ror2

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_038874.3	Gene:	Ror2 / 26564	MGIID:	1347521	Length:	944	Species:	Mus musculus

Alignment Length:	724	Identity:	222/724 - (30%)
Similarity:	338/724 - (46%)	Gaps:	106/724 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VVERVLRGMVLK--WGANLAVLGL---------CVFLFASATHANSLNAIEEP------VTRRHH 56
            ||:...|.::.|  :|:.|.:..|         ||     ||  |.|..|...      :...|.
Mouse   102 VVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCV-----AT--NGLKTITATGVLYVRLGPTHS 159

  Fly    57 QRHH-EREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGL--- 117
            ..|: :.:.:|:|:|.||.|..|..::..:..|.......|....::|.|.  .:|...|.|
Mouse   160 PNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAF--TMIGTSTQLSDQ 222

  Fly   118 CREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHF 182
            |.:.|....|.:.||.|...........||.::|:......|..::.:...    |..|..|  .
Mouse   223 CSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARS----NPLILMR--L 281

  Fly   183 RLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQY 247
            :||.|.:|| ...|....||..||:...:.... :.|.||:|..|.|..:.:|||..||.|..|:
Mouse   282 QLPKCEALP-MPESPDAANCMRIGIPAERLGRY-HQCYNGSGADYRGMASTTKSGHQCQPWALQH 344

  Fly   248 PHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPI 312
            ||.|......|.:|..|..||||.||:...|||:|.:::||.:.||:|.|            :|.
Mouse   345 PHSHRLSSTEFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRVELCDVPPC------------SPR 397

  Fly   313 KMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGN 377
            ...|.   .::::|     |..:.:.|:|..::.|.......|.|.|:|.:
Mouse   398 DGSKM---GILYIL-----VPSIAIPLVIACLFFLVCMCRNKQKASASTPQ-------------- 440

  Fly   378 LNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIV 442
                                  .|......|..:.:..::....||       |:::..  ..:.
Mouse   441 ----------------------RRQLMASPSQDMEMPLISQHKQAK-------LKEISL--STVR 474

  Fly   443 YVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRL 507
            ::..||:..||:|::....|..|.:....||:|.|||.|...::.:|.:||.|.|...|||||.|
Mouse   475 FMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCL 539

  Fly   508 LGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELH---LLQMAANIAAGML 569
            |||....:|:.::|.|.:.|||.|||...||::...:...||...:.|.   .:.:.|.|||||.
Mouse   540 LGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHVVAQIAAGME 604

  Fly   570 YLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKF 634
            :||....||:||||||.|:.:.:.|:|:|.||..::|..||||...|..:|||||..|:::|.||
Mouse   605 FLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKF 669

  Fly   635 SLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPS 699
            |::||:|:||:.||||||:.||||.|.::::|::.|:...||.|||:.|..|||||..|||..||
Mouse   670 SIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPS 734

  Fly   700 ERPGFAEIN 708
            .||.|.:|:
Mouse   735 RRPRFKDIH 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	36/147 (24%)
		KR	217..299	CDD:214527	35/81 (43%)
		PTKc_Musk	435..713	CDD:133181	118/277 (43%)
		Pkinase_Tyr	441..707	CDD:285015	117/268 (44%)
Ror2	NP_038874.3	I-set	64..152	CDD:254352	14/56 (25%)
		IGc2	75..139	CDD:197706	11/43 (26%)
		CRD_TK_ROR2	170..309	CDD:143577	37/147 (25%)
		KR	314..395	CDD:214527	35/92 (38%)
		PKc_like	466..749	CDD:304357	118/280 (42%)
		Pkinase_Tyr	473..746	CDD:285015	118/271 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..779
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..879
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..929
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7749
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820