DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and Ror1

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_038873.2	Gene:	Ror1 / 26563	MGIID:	1347520	Length:	937	Species:	Mus musculus

Alignment Length:	657	Identity:	226/657 - (34%)
Similarity:	324/657 - (49%)	Gaps:	87/657 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELI---SDLTGLCREAAEK 124
            |.||:|:|.||.|..|..::..:..|.......|....|:|.|.  .:|   |.|:..|.:.|..
Mouse   163 EYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAF--TMIGTSSHLSDKCSQFAIP 225

  Fly   125 MLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSS 189
            .||.||||.|...........||.::|:......|..:::....    |..|..|  .:||||..
Mouse   226 SLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCQTEYIFARS----NPMILMR--LKLPNCED 284

  Fly   190 LPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQP 254
            ||. ..|....||..||:........::.|.|..|..|.||::|:|||..||.|::||||.|...
Mouse   285 LPQ-PESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFT 348

  Fly   255 PLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFF- 318
            .|.|.:|..|.:||||.|.::..|||:|:||:.:...||||.|      ::.|.....|||..:
Mouse   349 ALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPAC------DSKDSKEKNKMEILYI 407

  Fly   319 -TPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSR 382
             .||:...|| |.|       |...:....:..|..|.|                       ..|
Mouse   408 LVPSVAIPLA-IAF-------LFFFICVCRNNQKSSSPP-----------------------VQR 441

  Fly   383 ETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSL 447
            :.....|..                         ..:|.....||.::.::|  |...:.::..|
Mouse   442 QPKPVRGQN-------------------------VEMSMLNAYKPKSKAKEL--PLSAVRFMEEL 479

  Fly   448 GQGAFGRVFQAR--APGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGV 510
            |:..||::::..  .||:...|   |||:|.|||..:.|...:|::||.|:||..|||||.|||.
Mouse   480 GECTFGKIYKGHLYLPGMDHAQ---LVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGA 541

  Fly   511 CALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQD----RLQLNELHLLQMAANIAAGMLYL 571
            ....:|:|:|||||..|||.|||...||::.....:.:    :..|:....|.:|..|||||.||
Mouse   542 VTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYL 606

  Fly   572 SERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSL 636
            |...|||:|||.||.||.|.:.|||:|.|||.:||..|||:......:||||||.|:|:|.|||.
Mouse   607 SSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSS 671

  Fly   637 ESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSER 701
            :||:|::|:.|||:|||.||||:|.:::|||:.:::..:|.|.::.|..:|:||..|||..||.|
Mouse   672 DSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRR 736

  Fly   702 PGFAEIN 708
            |.|.:|:
Mouse   737 PRFKDIH 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	41/147 (28%)
		KR	217..299	CDD:214527	38/81 (47%)
		PTKc_Musk	435..713	CDD:133181	124/280 (44%)
		Pkinase_Tyr	441..707	CDD:285015	122/271 (45%)
Ror1	NP_038873.2	I-set	63..148	CDD:254352
		Ig	75..143	CDD:143165
		CRD_TK_ROR1	166..307	CDD:143576	42/149 (28%)
		KR	311..393	CDD:214527	38/87 (44%)
		PTKc_Ror1	467..749	CDD:270672	125/282 (44%)
		Pkinase_Tyr	473..746	CDD:285015	123/274 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..778
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..890
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..937
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7749
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222671at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820