DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and Ntrk2

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001020245.1	Gene:	Ntrk2 / 18212	MGIID:	97384	Length:	821	Species:	Mus musculus

Alignment Length:	700	Identity:	203/700 - (28%)
Similarity:	303/700 - (43%)	Gaps:	197/700 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 FCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNG 222
            :|.|:       ..:||.:   .:.::||| .||  :|.:..||     ||..:...|:..|..|
Mouse   175 YCLNE-------SSKNMPL---ANLQIPNC-GLP--SARLAAPN-----LTVEEGKSVTLSCSVG 221

  Fly   223 -------------------------NGRFYMGTMNVSKSG--IPC-------QRWDTQYPHKHFQ 253
                                     .|...:..::...||  |.|       :..|:.....||.
Mouse   222 GDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFA 286

  Fly   254 PPLVFHQLLEGENYCRNAGGEEPHPWC--YTV----DESVRW--------------------QHC 292
            |.:.|   ||...        ..|.||  :||    ..:::|                    .|.
Mouse   287 PTITF---LESPT--------SDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHT 340

  Fly   293 DIPMC--------------------------------------------PDYVDPNAVDLNTPIK 313
            :...|                                            |:|.:....|..||..
Mouse   341 EYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTD 405

  Fly   314 M---------------------EKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPA 357
            :                     |.....:::.:.:.:||..:|     :||:.||::|..:
Mouse   406 IGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLV-----MLLLLKLARHSKF---- 461

  Fly   358 GAATAECSVSMRGGGDCGGNLNTSRETLG--GNG-NTNTLAKWGTIRSTATIHSNCVALTTVTNV 419
                     .|:|......|.:.|...|.  .|| ||.:.::.|   ..|.|    :.:|.:..:
Mouse   462 ---------GMKGPASVISNDDDSASPLHHISNGSNTPSSSEGG---PDAVI----IGMTKIPVI 510

  Fly   420 SDAK-------GTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKML 477
            .:.:       ..||:..::.::  |.:||..|.||:||||:||.|....|.|:|:.:|||||.|
Mouse   511 ENPQYFGITNSQLKPDTFVQHIK--RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTL 573

  Fly   478 KDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATH 542
            | ||||..:.||.|||.||....|.:||:..|||..|.|:.::||||..|||::||||..|.|..
Mouse   574 K-DASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL 637

  Fly   543 QAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYL 607
            .|......:|.:..:|.:|..|||||:||:.:.||||||||||||:.|::.|||.|||:|..:|.
Mouse   638 MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 702

  Fly   608 QDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKE 672
            .|||:...:..:||||||.|||:|.||:.|||||:.|:.|||:|::..||::.|::.|||:.|.:
Mouse   703 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 767

  Fly   673 GNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESECKA 722
            |.||..|...|..||.||..||.|:|..|.....|     |::.::..||
Mouse   768 GRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSI-----HTLLQNLAKA 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	14/53 (26%)
		KR	217..299	CDD:214527	22/185 (12%)
		PTKc_Musk	435..713	CDD:133181	134/277 (48%)
		Pkinase_Tyr	441..707	CDD:285015	132/265 (50%)
Ntrk2	NP_001020245.1	LRR_8	92..150	CDD:338972
		LRR 1	92..113
		LRR 2	116..137
		TPKR_C2	152..195	CDD:374888	7/30 (23%)
		Ig	205..283	CDD:386229	12/82 (15%)
		Ig_TrkB_d5	301..379	CDD:143263	7/77 (9%)
		Interaction with MAPK8IP3/JIP3. /evidence=ECO:0000250\|UniProtKB:Q63604	454..465		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..497		7/25 (28%)
		PTKc_TrkB	531..818	CDD:270675	136/289 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1026
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810