DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrk and Ntrk2

DIOPT Version :10

Sequence 1:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_001020245.1 Gene:Ntrk2 / 18212 MGIID:97384 Length:821 Species:Mus musculus


Alignment Length:700 Identity:203/700 - (28%)
Similarity:303/700 - (43%) Gaps:197/700 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 FCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNG 222
            :|.|:       ..:||.:   .:.::||| .||  :|.:..||     ||..:...|:..|..|
Mouse   175 YCLNE-------SSKNMPL---ANLQIPNC-GLP--SARLAAPN-----LTVEEGKSVTLSCSVG 221

  Fly   223 -------------------------NGRFYMGTMNVSKSG--IPC-------QRWDTQYPHKHFQ 253
                                     .|...:..::...||  |.|       :..|:.....||.
Mouse   222 GDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFA 286

  Fly   254 PPLVFHQLLEGENYCRNAGGEEPHPWC--YTV----DESVRW--------------------QHC 292
            |.:.|   ||...        ..|.||  :||    ..:::|                    .|.
Mouse   287 PTITF---LESPT--------SDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHT 340

  Fly   293 DIPMC--------------------------------------------PDYVDPNAVDLNTPIK 313
            :...|                                            |:|.:....|..||..
Mouse   341 EYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTD 405

  Fly   314 M---------------------EKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPA 357
            :                     |.....:::.:.:.:||..:|     :||:.||::|..:    
Mouse   406 IGDTTNKSNEIPSTDVADQSNREHLSVYAVVVIASVVGFCLLV-----MLLLLKLARHSKF---- 461

  Fly   358 GAATAECSVSMRGGGDCGGNLNTSRETLG--GNG-NTNTLAKWGTIRSTATIHSNCVALTTVTNV 419
                     .|:|......|.:.|...|.  .|| ||.:.::.|   ..|.|    :.:|.:..:
Mouse   462 ---------GMKGPASVISNDDDSASPLHHISNGSNTPSSSEGG---PDAVI----IGMTKIPVI 510

  Fly   420 SDAK-------GTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKML 477
            .:.:       ..||:..::.::  |.:||..|.||:||||:||.|....|.|:|:.:|||||.|
Mouse   511 ENPQYFGITNSQLKPDTFVQHIK--RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTL 573

  Fly   478 KDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATH 542
            | ||||..:.||.|||.||....|.:||:..|||..|.|:.::||||..|||::||||..|.|..
Mouse   574 K-DASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVL 637

  Fly   543 QAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYL 607
            .|......:|.:..:|.:|..|||||:||:.:.||||||||||||:.|::.|||.|||:|..:|.
Mouse   638 MAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 702

  Fly   608 QDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKE 672
            .|||:...:..:||||||.|||:|.||:.|||||:.|:.|||:|::..||::.|::.|||:.|.:
Mouse   703 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 767

  Fly   673 GNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESECKA 722
            |.||..|...|..||.||..||.|:|..|.....|     |::.::..||
Mouse   768 GRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKSI-----HTLLQNLAKA 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrkNP_477255.1 CRD_FZ 67..212 CDD:470581 14/53 (26%)
KR 217..299 CDD:214527 22/185 (12%)
PTKc_Musk 435..713 CDD:133181 134/277 (48%)
Ntrk2NP_001020245.1 LRR_8 92..150 CDD:404697
LRR 1 92..113
LRR 2 116..137
LRRCT_2 151..195 CDD:465313 7/30 (23%)
Ig 205..283 CDD:472250 12/82 (15%)
Ig strand B 214..218 CDD:409353 1/3 (33%)
Ig strand C 227..230 CDD:409353 0/2 (0%)
Ig strand E 245..252 CDD:409353 1/6 (17%)
Ig strand F 262..268 CDD:409353 2/5 (40%)
Ig strand G 276..279 CDD:409353 1/2 (50%)
IgI_TrkB_d5 286..379 CDD:409441 12/103 (12%)
Ig strand A 286..294 CDD:409441 3/10 (30%)
Ig strand A' 295..298 CDD:409441 0/10 (0%)
Ig strand B 301..309 CDD:409441 4/7 (57%)
Ig strand C 312..319 CDD:409441 1/6 (17%)
Ig strand C' 322..325 CDD:409441 0/2 (0%)
Ig strand D 330..335 CDD:409441 0/4 (0%)
Ig strand E 341..349 CDD:409441 1/7 (14%)
Ig strand F 357..365 CDD:409441 0/7 (0%)
Ig strand G 368..376 CDD:409441 0/7 (0%)
Interaction with MAPK8IP3/JIP3. /evidence=ECO:0000250|UniProtKB:Q63604 454..465 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 474..497 7/25 (28%)
PTKc_TrkB 531..818 CDD:270675 136/289 (47%)
Blue background indicates that the domain is not in the aligned region.

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