DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrk and Ntrk1

DIOPT Version :9

Sequence 1:NP_477255.1 Gene:Nrk / 36445 FlyBaseID:FBgn0020391 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_001028296.1 Gene:Ntrk1 / 18211 MGIID:97383 Length:799 Species:Mus musculus


Alignment Length:641 Identity:198/641 - (30%)
Similarity:299/641 - (46%) Gaps:118/641 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 PNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCS-SLPHYNA 195
            ||..:|.|..|     |..||...|.....||:|.|  .|....:|..|.  ||:.. .|.:..:
Mouse   203 PNDSVEVGDDV-----FLQCQVEGLALQQADWILTE--LEGAATVKKFGD--LPSLGLILVNVTS 258

  Fly   196 SMRRPNCSYIGLTELKESEVSYDCR-NGNGRFYMG----------TMNVSKSGIPCQRW------ 243
            .:.:.|.:.....::..:|||.... :.....::|          ..:|.....|..||      
Mouse   259 DLNKKNVTCWAENDVGRAEVSVQVSV
SFPASVHLGLAVEQHHWCIPFSVDGQPAPSLRWLFNGSV 323

  Fly   244 --DTQYPHKHFQPPLVFHQLLEGE----------------------NY---CRNAGGEE------ 275
              :|.:         :|.|.||..                      ||   ..|..|:.      
Mouse   324 LNETSF---------IFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASVMA 379

  Fly   276 ---PHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTL 337
               .:|:.:..::       .||:....||.|:.. ..|:: :|..||..:.:..|:...|.:.|
Mouse   380 AFMDNPFEFNPED-------PIPVSFSPVDGNSTS-RDPVE-KKDETPFGVSVAVGLAVSAALFL 435

  Fly   338 HLMILLVYKLSKHKDY--SQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTI 400
            ..::|::.|..:...:  ::||..|..:           |..::....||||:..:.|..|...:
Mouse   436 SALLLVLNKCGQRSKFGINRPAVLAPED-----------GLAMSLHFMTLGGSSLSPTEGKGSGL 489

  Fly   401 RSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVP 465
            :.....:....:.|.|.::.                 |.||:....||:||||:||.|....|:.
Mouse   490 QGHIMENPQYFSDTCVHHIK-----------------RQDIILKWELGEGAFGKVFLAECYNLLN 537

  Fly   466 DQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLS 530
            ||:.:|||||.|| :||:..:.||:|||.||....|.:|||..|||..|.|:.::||||..|||:
Mouse   538 DQDKMLVAVKALK-EASENARQDFQREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLN 601

  Fly   531 EFLRACSPYATHQAPTQD----RLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEH 591
            .|||:..|.|...|..:|    .|.|.:  ||.:|:.:||||:||:...||||||||||||:.:.
Mouse   602 RFLRSHGPDAKLLAGGEDVAPGPLGLGQ--LLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQG 664

  Fly   592 MAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQ 656
            :.|||.|||:|..||..|||:......:||||||.|||||.|||.|||||::|:.|||:|::..|
Mouse   665 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQ 729

  Fly   657 PYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQ 712
            |::.|::.|.|:.|.:|..|..|...|..|||:||.||.|:|.:|....:::..:|
Mouse   730 PWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQ 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrkNP_477255.1 CRD_FZ 67..212 CDD:295308 20/80 (25%)
KR 217..299 CDD:214527 17/134 (13%)
PTKc_Musk 435..713 CDD:133181 134/282 (48%)
Pkinase_Tyr 441..707 CDD:285015 131/269 (49%)
Ntrk1NP_001028296.1 leucine-rich repeat 68..92 CDD:275378
LRR 1 90..113
LRR_8 92..150 CDD:290566
leucine-rich repeat 93..116 CDD:275378
LRR 2 116..137
leucine-rich repeat 117..139 CDD:275378
leucine-rich repeat 140..152 CDD:275378
TPKR_C2 151..194 CDD:301599
Ig_TrkABC_d4 197..284 CDD:143173 23/89 (26%)
Ig_TrKABC_d5 301..382 CDD:143172 13/89 (15%)
Interaction with SQSTM1. /evidence=ECO:0000250 472..493 6/20 (30%)
PKc_like 507..786 CDD:304357 134/299 (45%)
TyrKc 513..784 CDD:197581 131/273 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1026
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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