DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and Hgf

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001276387.1	Gene:	Hgf / 15234	MGIID:	96079	Length:	728	Species:	Mus musculus

Alignment Length:	256	Identity:	73/256 - (28%)
Similarity:	101/256 - (39%)	Gaps:	62/256 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 REREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKML 126
            ::.:|| ||....|:      .|..|....:|...::            :.|:. .|.| .|.|.
Mouse   171 KDLQEN-YCRNPRGE------EGGPWCFTSNPEVRYE------------VCDIP-QCSE-VECMT 214

  Fly   127 C---AYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSR--------G 180
            |   :|..|..|.|.|:.         ||.         |  .::...|:.|:..|        .
Mouse   215 CNGESYRGPMDHTESGKT---------CQR---------W--DQQTPHRHKFLPERYPDKGFDDN 259

  Fly   181 HFRLPNCSSLPH-YNASMRRP-------NCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSG 237
            :.|.|:....|. |......|       .|::..:.|......:.:|..|.|..|.||.|...:|
Mouse   260 YCRNPDGKPRPWCYTLDPDTPWEYCAIKTCAHSAVNETDVPMETTECIQGQGEGYRGTSNTIWNG 324

  Fly   238 IPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHC-DIPMC 297
            |||||||:||||||...|..|......||||||..|.| .|||:|.|.::|..:| .||.|
Mouse   325 IPCQRWDSQYPHKHDITPENFKCKDLRENYCRNPDGAE-SPWCFTTDPNIRVGYCSQIPKC 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	31/163 (19%)
		KR	217..299	CDD:214527	41/82 (50%)
		PTKc_Musk	435..713	CDD:133181
		Pkinase_Tyr	441..707	CDD:285015
Hgf	NP_001276387.1	PAN_APPLE	41..123	CDD:238074
		KR	127..209	CDD:214527	10/57 (18%)
		KR	211..289	CDD:214527	19/97 (20%)
		KR	305..385	CDD:214527	41/81 (51%)
		KR	389..471	CDD:238056
		Tryp_SPc	495..719	CDD:214473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000