DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrk and F2

DIOPT Version :9

Sequence 1:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_034298.1	Gene:	F2 / 14061	MGIID:	88380	Length:	618	Species:	Mus musculus

Alignment Length:	467	Identity:	101/467 - (21%)
Similarity:	155/467 - (33%)	Gaps:	150/467 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SMRRPNCSYIGLTELKESEVSYDCRNGN-----GRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPP 255
            |:|:|.            |...||..|.     |..|:||:||:.:||.||.|.::||||    |
Mouse    93 SVRKPR------------ETFMDCLEGRCAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHK----P 141

  Fly   256 LVFHQLLEG----ENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAV---------- 306
            .:......|    ||:|||.......|||||.|.:||.:.|.:|:|........|
Mouse   142 EINSTTHPGADLKENFCRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKD 206

  Fly   307 DLNTPI-----KMEKFFTPSMIFLLAGIGFVAIVTLHLMIL----LVYK-LSKHKDYSQPAGAAT 361
            :|:.|:     :..:.:.          |.:|:.||....|    |..| |||::|:........
Mouse   207 NLSPPLGQCLTERGRLYQ----------GNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVE 261

  Fly   362 ------------AECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALT 414
                        |.|.|:.:.|.....|||...|.:|              .....:..:....|
Mouse   262 NFCRNPDWDEEGAWCYVAGQPGDFEYCNLNYCEEAVG--------------EENYDVDESIAGRT 312

  Fly   415 TVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKD 479
            |                        |..:.....:..|| :.:|.. ||.|     |...|.|||
Mouse   313 T------------------------DAEFHTFFNEKTFG-LGEADC-GLRP-----LFEKKSLKD 346

  Fly   480 DASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQA 544
            ....:: :|...:..::..:|...     |:              ||..:..|.::........:
Mouse   347 TTEKEL-LDSYIDGRIVEGWDAEK-----GI--------------APWQVMLFRKSPQELLCGAS 391

  Fly   545 PTQDRLQLNELHLLQMAANIAAGMLYLS-ERKFVHRDLATRNCLINEHMAVK----IADFGLSHK 604
            ...||..|...|.:          ||.. ::.|...||..|   |.:|...:    :....:..|
Mouse   392 LISDRWVLTAAHCI----------LYPPWDKNFTENDLLVR---IGKHSRTRYERNVEKISMLEK 443

  Fly   605 IYLQDYYKGDEN 616
            ||:...|...||
Mouse   444 IYVHPRYNWREN 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308	3/15 (20%)
		KR	217..299	CDD:214527	36/90 (40%)
		PTKc_Musk	435..713	CDD:133181	36/187 (19%)
		Pkinase_Tyr	441..707	CDD:285015	35/181 (19%)
F2	NP_034298.1	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527	34/85 (40%)
		KR	213..295	CDD:214527	18/91 (20%)
		Thrombin_light	313..360	CDD:286482	14/78 (18%)
		Tryp_SPc	360..610	CDD:214473	23/128 (18%)
		Tryp_SPc	361..613	CDD:238113	23/127 (18%)
		High affinity receptor-binding region which is also known as the TP508 peptide. /evidence=ECO:0000250	548..570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000