DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and PCSK7

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_004707.2	Gene:	PCSK7 / 9159	HGNCID:	8748	Length:	785	Species:	Homo sapiens

Alignment Length:	795	Identity:	159/795 - (20%)
Similarity:	260/795 - (32%)	Gaps:	298/795 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 RNVDDFLSISVNVHDEG---NVLEVVGMSSPHGTH-VSS----------IASGNH---------- 371
            |||.. ..::|.|.|:|   .:.::....||.|:: ::|          :.:|||
Human   174 RNVTG-RGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIA 237

  Fly   372 ----SSRDVDGVAPNAKIVSMTIGDGRL-GSMETGTALVRAMTKVMEL-----CR-----DGRRI 421
                :|....|||..::|..:.:.||.| .|||     ..|..|..::     |.     ||:.:
Human   238 AVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSME-----AVAFNKHYQINDIYSCSWGPDDDGKTV 297

  Fly   422 DVINMSYGEHANWSNSGRIGE--LMNEVV---NKYGVVWVASAGNHGP------------ALCTV 469
            |      |.|       ::|:  |.:.|:   ..:|.::|.::||.|.            ::.||
Human   298 D------GPH-------QLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTV 349

  Fly   470 GTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASV 534
             |...:.:...:...|.....|:...::..:|:..::.| |..|  :..|.|   |..|
Human   350 -TIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVT-TDWD--LQKGTG---CTEG------ 401

  Fly   535 PQFTMSKSQLMNGTSMAAPHVAGAVALLIS---GLKQQNIEY------SPYSIKRAISVTATKLG 590
                      ..|||.|||..||.:||::.   .|..:::::      :.|..:||..|| .:.|
Human   402 ----------HTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTATRYEDRRAEWVT-NEAG 455

  Fly   591 YVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYNV-YIE 654
            :......|.||||..:..                      ||.|        ...|:.|.. |:.
Human   456 FSHSHQHGFGLLNAWRLV----------------------NAAK--------IWTSVPYLASYVS 490

  Fly   655 PIFYNDKEADPKDKFNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRA 719
            |:...:| |.|:...:..|..|:          :.:||           :.:||:...|.||  .
Human   491 PVLKENK-AIPQSPRSLEVLWNV----------SRMDL-----------EMSGLKTLEHVAV--T 531

  Fly   720 YDTDCVQKGSLFEIPV--------TVVQPHVLESDQ---NTPVFEPASSKGDNS----------- 762
            ......::||| |:.:        .:..|..::||.   |...|......|:.:
Human   532 VSITHPRRGSL-ELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDV 595

  Fly   763 --VEFQPNTIQRDFILVPERATWAEL----RMRITDPNRGEDIGKFFVHTNQLLPKQSCRKL--- 818
              ..||.. |.|.:.|....:.|:.:    |.|:.:....   || ::|.:..||.....|:
Human   596 GDESFQVG-ILRQWQLTLYGSVWSAVDIRDRQRLLESAMS---GK-YLHDDFALPCPPGLKIPEE 655

  Fly   819 -------ETMK-IVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLR-------FRG 868
                   .|:| :|.||                   |...:|:.|....:..|.|       .|.
Human   656 DGYTITPNTLKTLVLVG-------------------CFTVFWTVYYMLEVYLSQRNVASNQVCRS 701

  Fly   869 VEAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVIPDGRQ 933
            ...|.|     |..|   |.:.|.                     ||.:..||.:::|  ||
Human   702 GPCHWP-----HRSR---KAKEEG---------------------TELESVPLCSSKD--PD--- 732

  Fly   934 VYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSHTSFTKLDK 998
                         :....|...|..:|||.....|...|.|.....||..   .|.|
Human   733 -------------EVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDC---PHQH-------- 773

  Fly   999 GEYTIRLQVRHEKRD 1013
                  |.|.|.|.:
Human   774 ------LDVPHGKEE 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	70/322 (22%)
		Peptidase_S8	331..600	CDD:278510	72/333 (22%)
		TPPII	892..1073	CDD:289357	23/122 (19%)
		TPPII_N	1144..1257	CDD:289360
PCSK7	NP_004707.2	S8_pro-domain	53..141	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	145..440	CDD:173789	65/307 (21%)
		Peptidase_S8	196..441	CDD:278510	58/285 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..219		4/21 (19%)
		P_proprotein	525..612	CDD:279782	18/90 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..751		19/97 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900