DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and MBTPS1

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_003782.1	Gene:	MBTPS1 / 8720	HGNCID:	15456	Length:	1052	Species:	Homo sapiens

Alignment Length:	1208	Identity:	229/1208 - (18%)
Similarity:	383/1208 - (31%)	Gaps:	474/1208 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 GLETLCDGKTVKVIERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVR 204
            |.:.|.|....|..|:..|.||                      :.|.|..|..:...:.|..|
Human    17 GKKHLGDRLEKKSFEKAPCPGC----------------------SHLTLKVEFSSTVVEYEYIV- 58

  Fly   205 VGLKSFSDLLPSKVRNNIVAQA----KLKHWDKPHKTATANASRKIVEFESQNPGEASKLPWDKK 265
                :|:....:|.||:.::.|    ::.:|             :|:  ...||  :|..|
Human    59 ----AFNGYFTAKARNSFISSALKSSEVDNW-------------RII--PRNNP--SSDYP---- 98

  Fly   266 ILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGWLTIVD------TTEQGDLDQALRIGEY 324
                 .|||:..:...:|.                 |.||:.|      .|.|..:.::|:..|.
Human    99 -----SDFEVIQIKEKQKA-----------------GLLTLEDHPNIKRVTPQRKVFRSLKYAES 141

  Fly   325 SRT-----------------------------------HETRNV-------------DDFL---- 337
            ..|                                   |.:|.:             .|.|
Human   142 DPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMG 206

  Fly   338 ----SISVNVHDEG---------NVLEVVGMSSP--------HGTHVSSIASGNHSSRDVDGVAP 381
                ::.|.|.|.|         ||.|....::.        |||.|:.:.:   |.|:..|.||
Human   207 YTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIA---SMRECQGFAP 268

  Fly   382 NAKIVSMTIGDGRLGSMETG--TALVRAMTKVMELCRDGRRIDVINMSYG--EHANWSNSGRIGE 442
            :|::....:......|..:.  .|...|:.|         :|||:|:|.|  :..:.....::.|
Human   269 DAELHIFRVFTNNQVSYTSWFLDAFNYAILK---------KIDVLNLSIGGPDFMDHPFVDKVWE 324

  Fly   443 LMNEVVNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVY 507
            |     ....|:.|::.||.||...|:..|.|  |..:||||. :..:...|.::.|     .:.
Human   325 L-----TANNVIMVSAIGNDGPLYGTLNNPAD--QMDVIGVGG-IDFEDNIARFSSR-----GMT 376

  Fly   508 TWTSRDPCIDGGQG------VTVCA-------PGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAV 559
            ||.     :.||.|      ||..|       .||..|            ::|||:|:|.|||||
Human   377 TWE-----LPGGYGRMKPDIVTYGAGVRGSGVKGGCRA------------LSGTSVASPVVAGAV 424

  Fly   560 ALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRF 624
            .||:|.::::.: .:|.|:|:|:..:|.:|..|:.|.||||.|::.:|::.|
Human   425 TLLVSTVQKREL-VNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQIL------------- 475

  Fly   625 SVRVGNNADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKFNFNVRLNLIASQPWVQCGAF 689
                                ||......:.|.:.:..|                ....|..|..
Human   476 --------------------NSYKPQASLSPSYIDLTE----------------CPYMWPYCSQ- 503

  Fly   690 LDLSYGTRSIAVRVD-PTGLQPGVHSAVIRAYDTDCVQKGSLFEIPVTVVQPHVLESDQNTPVFE 753
             .:.||.....|.|. ..|:  ||...::...|.                ||::.::..|..|..
Human   504 -PIYYGGMPTVVNVTILNGM--GVTGRIVDKPDW----------------QPYLPQNGDNIEVAF 549

  Fly   754 PASS-----KGDNSVEFQPNTIQRDFILVPERATW-----AELRMRITDPNRGEDIGKFFVHTNQ 808
            ..||     .|..::...         :..:.|:|     ..:.:.:..|...|.
Human   550 SYSSVLWPWSGYLAISIS---------VTKKAASWEGIAQGHVMITVASPAETES---------- 595

  Fly   809 LLPKQSCRKLETMKI-VSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGVEAH 872
               |....:..|:|: :.|     .|:....:|.|:|       |..|      ::||:
Human   596 ---KNGAEQTSTVKLPIKV-----KIIPTPPRSKRVL-------WDQY------HNLRY------ 633

  Fly   873 NPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVI-PDGRQVYQ 936
             |..|.                   .:..|::||            .||....|.| .:.|.:||
Human   634 -PPGYF-------------------PRDNLRMKN------------DPLDWNGDHIHTNFRDMYQ 666

  Fly   937 NL--LAFNLNVAKAA----DVSIYAPIFNDLLYEAE---FESQMWML---FDANKALVATGDAHS 989
            :|  :.:.:.|..|.    |.|.|..:   |:.::|   |..::..|   .|...:||...|.::
Human   667 HLRSMGYFVEVLGAPFTCFDASQYGTL---LMVDSEEEYFPEEIAKLRRDVDNGLSLVIFSDWYN 728

  Fly   990 HTSFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDF----YE------NYNQC 1044
            .:...|       ::....:.::..:.....||:.|..:|.|...:.|    ||      |::..
Human   729 TSVMRK-------VKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMY 786

  Fly  1045 IVGGRKYVSSP-----------------LRLSTRVLYIAPITQERLTKANLPAQ----------- 1081
            ...|......|                 |:..|.|:...||    |....:||:
Human   787 YASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPI----LGLYQIPAEGGGRIVLYGDS 847

  Fly  1082 -----------CAWLSGNLVFPQDEVGRRVAQHPFTYILNPAEKKSHTNGSSNGSSAAGSTATA- 1134
                       |.||...|:           |:. :|.:.| ...||:.......|.|||....
Human   848 NCLDDSHRQKDCFWLLDALL-----------QYT-SYGVTP-PSLSHSGNRQRPPSGAGSVTPER 899

  Fly  1135 ---------AAVTTANGAKPK---APATPQAATSVTNP 1160
                     :.|..|:...||   .||.|:.:.:...|
Human   900 MEGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQP 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	115/548 (21%)
		Peptidase_S8	331..600	CDD:278510	82/323 (25%)
		TPPII	892..1073	CDD:289357	41/220 (19%)
		TPPII_N	1144..1257	CDD:289360	6/20 (30%)
MBTPS1	NP_003782.1	Peptidases_S8_SKI-1_like	203..455	CDD:173805	75/294 (26%)
		Peptidase_S8	209..464	CDD:278510	79/297 (27%)
		DUF4350	651..724	CDD:290957	18/75 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..899		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900