Protein Alignment TppII and PRB1

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: NP_010854.1
• Gene: PRB1 / 856649
• SGDID: S000000786
• Length: 635
• Species: Saccharomyces cerevisiae
• Alignment Length: 682
• Identity: 141/682 - (20%)
• Similarity: 222/682 - (32%)
• Gaps: 221/682 - (32%)

  Fly    12 LRLYKNFGLLGQKASVGLTLPIISLSRPYMAYMGTERSVVMITAPATKEFAESSERSNSSKKTTN 76
            ::|......||...|:...|.|     |.:........::      .||......|.....|..:
Yeast     1 MKLENTLFTLGALGSISAALVI-----PNLENAADHHELI------NKEDHHERPRKVEFTKDDD 54

  Fly    77 KEQSDKSAESRMATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGL 141
            :|.||.            |....|....|...|.   .::.||::|:             ||:|.
Yeast    55 EEPSDS------------EDKEHGKFHKKGRKGQ---DKESPEFNGK-------------RASGS 91

  Fly   142 ETLC--DGKTVKVIERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVR 204
            ....  .||.:|  .:::.|...|.|.||| .|...|   |...|.::            ||.::
Yeast    92 HGSAHEGGKGMK--PKHESSNDDDNDDKKK-KPHHKG---GCHENKVE------------EKKMK 138

  Fly   205 VGLKSFSDLLPSKVRNNIVAQAKLKHWDKP-HKTATANASRKIVEFESQNPGEASKLPWDKKIL- 267
                      ..||:..       ||.:|. .|....|....:|.....||...||:..::.|:
Yeast   139 ----------GKKVKGK-------KHHEKTLEKGRHHNRLAPLVSTAQFNPDAISKIIPNRYIIV 186

  Fly   268 ------KENLDFELE-----MLNSYEKV-------------------YGDIKTSYDC-ILFPTAD 301
                  :|.:||..|     .|.|.|.:                   .|.|:.|::. .||....
Yeast   187 FKRGAPQEEIDFHKENVQQAQLQSVENLSAEDAFFISTKDTSLSTSEAGGIQDSFNIDNLFSGYI 251

  Fly   302 GWLT--IVDTTEQGDL------DQALRIGEYSR-----------THETR-NVDDF---------- 336
            |:.|  |||...|..|      |..:...|:..           :|..| |:..|
Yeast   252 GYFTQEIVDLIRQNPLVDFVERDSIVEATEFDTQNSAPWGLARISHRERLNLGSFNKYLYDDDAG 316

  Fly   337 -------LSISVNV-HDEGNVLEVVGMSSP----------HGTHVSSIASGNHSSRDVDGVAPNA 383
                   :...||: |.:.....:.|.:.|          ||||.:...:..|.     |||.||
Yeast   317 RGVTSYVIDTGVNINHKDFEKRAIWGKTIPLNDEDLDGNGHGTHCAGTIASKHY-----GVAKNA 376

  Fly   384 KIVSMTI----GDGRLGSMETGTA-LVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGEL 443
            .:|::.:    |.|.:..:..|.. ..:|..|..:..:.|.:....|||.|        |.....
Yeast   377 NVVAVKVLRSNGSGTMSDVVKGVEYAAKAHQKEAQEKKKGFKGSTANMSLG--------GGKSPA 433

  Fly   444 MNEVVN---KYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVG------AYVSPQMMEAEYAMR 499
            ::..||   :.|:.:..:|||.....|.. :|....:...:|..      ||.|
Yeast   434 LDLAVNAAVEVGIHFAVAAGNENQDACNT-SPASADKAITVGASTLSDDRAYFS----------- 486

  Fly   500 EKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLIS 564
                    .|         |:.|.|.|||..|.|....:...:..::|||||:|||||.:...:|
Yeast   487 --------NW---------GKCVDVFAPGLNILSTYIGSDDATATLSGTSMASPHVAGLLTYFLS 534

  Fly   565 GLKQQNIEY--------SPYSIKRAISVTATK 588
            .....:.|:        :|..:|:.:...:||
Yeast   535 LQPGSDSEFFELGQDSLTPQQLKKKLIHYSTK 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	125/593 (21%)
		TPPII	892..1077	CDD:463636
		TPPII_N	1144..1257	CDD:403697
PRB1	NP_010854.1	Inhibitor_I9	182..278	CDD:428674	21/95 (22%)
		Peptidases_S8_PCSK9_ProteinaseK_like	290..566	CDD:173790	66/317 (21%)