DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and KEX2

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_014161.1	Gene:	KEX2 / 855483	SGDID:	S000005182	Length:	814	Species:	Saccharomyces cerevisiae

Alignment Length:	392	Identity:	73/392 - (18%)
Similarity:	122/392 - (31%)	Gaps:	148/392 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 ILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHET 330
            |:.:.||:|.|          |:|.:: |     |:|.....|.|               ...:.
Yeast   173 IVDDGLDYENE----------DLKDNF-C-----AEGSWDFNDNT---------------NLPKP 206

  Fly   331 RNVDDFLSISVNVHDEGNVLEVVGMSSPHGTH-VSSIASGNHSSRDVDGVAPNAKIVSMTIGDGR 394
            |..||:                      |||. ...||:...::....||..||||..:.|..|.
Yeast   207 RLSDDY----------------------HGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGD 249

  Fly   395 LGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNK--------- 450
            :.:.:...:|:..:..          .|:.:.|:|.    ::.||..:..:::|.|
Yeast   250 ITTEDEAASLIYGLDV----------NDIYSCSWGP----ADDGRHLQGPSDLVKKALVKGVTEG 300

  Fly   451 ---YGVVWVASAGNHGPA--------------LCTVGT--PPDISQPSLIGVGAYVSPQMMEAEY 496
               .|.::|.::||.|..              ..|:|.  ..|:..|...|..|.::
Yeast   301 RDSKGAIYVFASGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMA-------- 357

  Fly   497 AMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVAL 561
                                     ||..:..|............|....|||.|||..||...|
Yeast   358 -------------------------VTYSSGSGEYIHSSDINGRCSNSHGGTSAAAPLAAGVYTL 397

  Fly   562 LIS---GLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQG--------------HGLLNVEKAFE 609
            |:.   .|..::::|  .||..|:.:.....|.....|.|              |.|:.:.|.:|
Yeast   398 LLEANPNLTWRDVQY--LSILSAVGLEKNADGDWRDSAMGKKYSHRYGFGKIDAHKLIEMSKTWE 460

  Fly   610 HL 611
            ::
Yeast   461 NV 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	66/354 (19%)
		Peptidase_S8	331..600	CDD:278510	57/314 (18%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
KEX2	NP_014161.1	Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	133..419	CDD:173789	65/347 (19%)
KEX2	NP_014161.1	COG4935	463..653	CDD:227271	73/392 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900