DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and RRT12

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_009974.1	Gene:	RRT12 / 850412	SGDID:	S000000641	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	463	Identity:	103/463 - (22%)
Similarity:	172/463 - (37%)	Gaps:	131/463 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 TANASRKIVEFESQNPGEASKLPWDKKILKENLDFEL---EMLNSYEK----------VYGDIKT 290
            |.|.|:.:|....::|..|..:|        |..||.   :.:||.|.          .|.|::.
Yeast    62 TMNLSKNLVNKLKKSPLVADIVP--------NFRFEAFEGDSVNSAESSYTFNATAKYSYEDVEE 118

  Fly   291 SYDCILFPTADGWLTIVDTTEQ-----GDLDQALRIGEYSRTHETRNVDDFLSISVNVHDEG--- 347
            ..:....|.|...|..:....|     ||.|:......|...|:.:..|    ::..:.|.|
Yeast   119 EQNITYQPDAPRHLARISRHYQLPFDVGDKDRYKSWFNYYYEHDYQGQD----VNAYIMDTGIFA 179

  Fly   348 -------NVLEVV-------GMSSPHGTHVSSIASGNHSSRDVDGVAPNAKIVSMTI----GDGR 394
                   .|::.:       |..:.|||||:.:....     ..|.|....:|.:.:    |.|.
Yeast   180 DHPEFEDRVIQGIDLTKEGFGDQNGHGTHVAGLVGSK-----TYGAAKRVNLVEVKVLGKDGSGE 239

  Fly   395 LGSMETGTA-LVRAMTKVMELCRDGRRIDVINMSYGEH----ANWSNSGRIGELMNEVVNKYGVV 454
            ..::.:|.. :|...|||..  ..|::. |.|:|.|..    .|.:..|.|.|         |:|
Yeast   240 ASNVLSGLEFIVEHCTKVSR--PQGKKC-VANLSLGSFRSPIINMAVEGAIEE---------GIV 292

  Fly   455 WVASAGNH-------GPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSR 512
            :||:|||.       .||          |..::|.|||:.......|:::          .|
Yeast   293 FVAAAGNFNLDAYWASPA----------SAENVITVGAFDDHIDTIAKFS----------NW--- 334

  Fly   513 DPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLIS-GLK----QQNIE 572
            .||      |.:.|||..|.|:.....:.:.:::||||:.|.|.|..|:|:| |::    .|.||
Yeast   335 GPC------VNIFAPGVEIESLSHLNYNDTLILSGTSMSTPIVTGVAAILLSKGIEPEMIAQEIE 393

  Fly   573 Y--------------SPYSIKRAISVTATKLGYVDPF-AQGHGLLNVEKAFEHLTEHRQSKDNML 622
            |              .|.:..:.:.....||.  ||: .:....||:|...:.|.|:..:....:
Yeast   394 YLSTRNVFHRRTLFFKPSTPNQILYNGVDKLD--DPYDDETFPRLNIEAIAKELEEYNATLQTPM 456

  Fly   623 RFSVRVGN 630
            ..:::.|:
Yeast   457 SENLQSGS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	93/419 (22%)
		Peptidase_S8	331..600	CDD:278510	73/321 (23%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
RRT12	NP_009974.1	Peptidases_S8_PCSK9_ProteinaseK_like	130..398	CDD:173790	75/317 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900