DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and Tpp2

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	XP_006244914.2	Gene:	Tpp2 / 81815	RGDID:	621584	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1391	Identity:	500/1391 - (35%)
Similarity:	761/1391 - (54%)	Gaps:	166/1391 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 MATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGLETLCDGKTVKV 152
            |||:...|.||...|:||.|||..:||.:|||||||.|.||:.|:||||.|.|::...|||. |:
  Rat     1 MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKP-KI 64

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGLKSFSDLLPSK 217
            |:..|.:|.|||:...:|.| ::|.|.||||..||:.    |..|:|.....:|:|:..|..|..
  Rat    65 IDIIDTTGSGDVNTATEVEP-KDGEITGLSGRVLKIP----ANWTNPSGKYHIGIKNGYDFYPKA 124

  Fly   218 VRNNIVAQAKLKHWDKPHKTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEMLNSYE 282
            ::..|..:.|.|.||..|:.|.|.|.||..||:..|.|.:..    .|::||.|..::|:|||:|
  Rat   125 LKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQA----NKLIKEELQSQVELLNSFE 185

  Fly   283 KVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHE--TRNVDDFLSISVNVHD 345
            |.|.|....|||:::...:.|...||:.|.|||.::..:..|....|  :....:.|:.|||::|
  Rat   186 KKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYD 250

  Fly   346 EGNVLEVVGMSSPHGTHVSSIASGNHSSR-DVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMT 409
            :||:|.:|.....|||||:|||:|:.... :.:||||.|:|:|:.|||.||.:|||||.|:|||.
  Rat   251 DGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMI 315

  Fly   410 KVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPPD 474
            :|:     ..:.|::|.||||..:|.|||||.|::||.|.|:..::|:||||:||.|.|||.|..
  Rat   316 EVI-----NHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGG 375

  Fly   475 ISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTM 539
            .:. |:|||||||||.||.|||::|||||.|.|||:||.|..||..||::.||||||||||.:|:
  Rat   376 TTS-SVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTL 439

  Fly   540 SKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNV 604
            ..:||||||||::|:..|.:||::||||..|::|:.:|::||:..||.|...::.||||||::.|
  Rat   440 RGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQV 504

  Fly   605 EKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQ-RNSIDYNVYIEPIFYNDKEADPKDK 668
            :||:::|.:: .|..|.|.|:|.||||  :||:||..|| ....|:.|.|||:|  .:..:..:|
  Rat   505 DKAYDYLIQN-TSFANRLGFTVTVGNN--RGIYLRDPVQVAAPSDHGVGIEPVF--PENTENSEK 564

  Fly   669 FNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEI 733
            .:|.:.|.|.::..||||.:.|:|....|.|.:||||.||:.|:|...:..||......|.||.:
  Rat   565 ISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRV 629

  Fly   734 PVT-VVQPHVLESDQNTPVFEPASSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGE 797
            |:| |:...|.||......|        ..|.|:|..|:|.|:.|||.|||||:.:....   .|
  Rat   630 PITAVIAAKVNESSHYDLAF--------TDVHFKPGQIRRHFVEVPEGATWAEVTVCSCS---SE 683

  Fly   798 DIGKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKY 862
            ...||.:|..||:.:::.|..|..|..|:..:...|.||.|..|:.:|.|||::|::....::.|
  Rat   684 VSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDY 748

  Fly   863 SLRFRGVEAHNPNAYVMHAGRGIHKLEIE-ALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRD 926
            ::.|.|:....|...: ||..||::.::: :|..||:.|.:.||:....|:|..||..|| .:||
  Rat   749 TISFHGIVCTAPQLNI-HASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPL-GSRD 811

  Fly   927 VIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSHT 991
            |:|:.||:|:.:|.::.:..|:.:|:...|:..:||||:||:||:|::||.||..:.:|||:.|.
  Rat   812 VLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQ 876

  Fly   992 SFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSSPL 1056
            ...||:||:||||||:|||:...|:::.:...:.|.:|::.|:||.:||::..::|.:|  ||.|
  Rat   877 YSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKK--SSSL 939

  Fly  1057 RLSTRV---LYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQH-------------PF 1105
            .|..:.   .::..:..:::.|...|.  .:|:|:|...:.|:|::..|.             |.
  Rat   940 TLPPKYNQPFFVTSLPDDKIPKGAGPG--CYLAGSLTLSKTELGKKAGQSAAKRQGKFKKDVIPV 1002

  Fly  1106 TYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQN 1170
            .|.|.|...|                       |.||:|
  Rat  1003 HYYLIPPPTK-----------------------TKNGSK-------------------------- 1018

  Fly  1171 DPPVDSSGSPASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANLLLI 1235
            |...||       :|.|...:::.|:.||.:...:.|.:   :..|||::...:|.:|...:..:
  Rat  1019 DKEKDS-------EKEKDLKEEFTEALRDLKIQWMTKLD---STDIYNELKETYPAYLPLYVARL 1073

  Fly  1236 QNIESNQLKSQLPLTFVNAQKTSPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSEALL 1300
            ..:                            |.:||..|:    |..||..|:.||...|..||.
  Rat  1074 HQL----------------------------DAEKERMKR----LNEIVDAANAVISHIDQTALA 1106

  Fly  1301 SYYGLKNDTRADAAKIKTNMDKQKNTLIEALSKKGIAVAK----------LAVLDDCIKD----- 1350
            .|..:|.|.|.|||.||.:|||||:||::||.:||.|:|.          .|..|...|:
  Rat  1107 VYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQPHDGAAAGDAEAKEEEGES 1171

  Fly  1351 SLAEINELYTEIIKFVDANDSKAIQFALWHAYAHGHYGRMYKYVVKLIEEKRTRDHFVELAAING 1415
            :|..::|.|.|..|:.|..|:|.:.||..||..:..|||..|:..||:|||.|::::.....:..
  Rat  1172 TLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMK 1236

  Fly  1416 ALGHEHIRTVINRMMITAFPSSFRLF 1441
            .||..|..:.....:...:|..:.:|
  Rat  1237 LLGWTHCASFTENWLPIMYPPDYCVF 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	225/490 (46%)
		Peptidase_S8	331..600	CDD:278510	139/269 (52%)
		TPPII	892..1073	CDD:289357	67/183 (37%)
		TPPII_N	1144..1257	CDD:289360	15/112 (13%)
Tpp2	XP_006244914.2	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	225/490 (46%)
Tpp2	XP_006244914.2	TPPII	777..963	CDD:403695	68/188 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354013
Domainoid	1	1.000	409	1.000	Domainoid score	I672
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2471
Inparanoid	1	1.050	814	1.000	Inparanoid score	I453
OMA	1	1.010	-	-		QHG58290
OrthoDB	1	1.010	-	-		D156304at2759
OrthoFinder	1	1.000	-	-		FOG0005779
OrthoInspector	1	1.000	-	-		oto98285
orthoMCL	1	0.900	-	-		OOG6_104037
Panther	1	1.100	-	-	LDO	PTHR43806
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4170
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810