DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and FRAS1

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_079350.5	Gene:	FRAS1 / 80144	HGNCID:	19185	Length:	4012	Species:	Homo sapiens

Alignment Length:	1231	Identity:	206/1231 - (16%)
Similarity:	382/1231 - (31%)	Gaps:	419/1231 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 LKLSPELMALNTDPEKAVRVGLKSFSDLLPSKVRNNIVAQAKLKHWDKPHKTATANASRKIVEFE 250
            :|:..||.|.:| |..|:..||:    |....|..  :.:..||      .|...:...:::...
Human  2067 MKIYTELPASDT-PHLAINQGLQ----LSAGSVAR--ITEQHLK------VTDIDSDDHQVMYIM 2118

  Fly   251 SQNPGEASKLPWDKKILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDL 315
            .::|| |.:|    :::|..   .||.::    :.|.|::      |..||        ..||.:
Human  2119 KEDPG-AGRL----QMMKHG---NLEQIS----IKGPIRS------FTQAD--------ISQGHV 2157

  Fly   316 DQALRIGEYSRT----------HETRNVDDFLSISV--------------NVHDEGNVLEVVGM- 355
            :.:...||...:          ...|.:|...|||:              .|.||.:|.::..:
Human  2158 EYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISILEDKSPPVITTNKGLVLDENSVKKITTLQ 2222

  Fly   356 -----------------------------SSPHGTHVSSIASGNHSSRDVDGV-----APNAKIV 386
                                         :|| |..:||....:.:||:|..|     ..::...
Human  2223 LSATDQDSGPTELIYRITRQPQLGHLEHAASP-GIQISSFTQADLTSRNVQYVHSSEAEKHSDAF 2286

  Fly   387 SMTIGDGRLGSMETGTALVRAMTKVMELCR---DGRRIDVINMSYGEHANWSNSGRIGELMNEVV 448
            |.|:.||           |..:|:...:..   |.....|.|:..          |:.|.|.:.:
Human  2287 SFTLSDG-----------VSEVTQTFHITLHPVDDSLPVVQNLGM----------RVQEGMRKTI 2330

  Fly   449 NKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNV------- 506
            .::.:..|.:.........|:..||..........|.:..   :.:.:.|::.....|
Human  2331 TEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFH---LTSTFTMKDIYQNRVSYSHDGS 2392

  Fly   507 ------YTWTSRD---PCI---DGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAV 559
                  :|:|..|   |..   :||:.:...||       ..|.:....:.:||    |.:
Human  2393 NSLKDRFTFTVSDGTNPFFIIEEGGKEIMTAAP-------QPFRVDILPVDDGT----PRI---- 2442

  Fly   560 ALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRF 624
               ::.|..|.:||  ...|....:|..:|..:||                     .::|..|.:
Human  2443 ---VTNLGLQWLEY--MDGKATNLITKKELLTMDP---------------------DTEDAQLVY 2481

  Fly   625 SVRVG-------NNADKGIHLRQGVQRNSIDYNV-YIEPIFYNDKEADPKDKFNFNV---RLNLI 678
            .:..|       |....|   |........|.|: .|..:.:.:|..:..|.|.|.|   :.|::
Human  2482 EITTGPKHGFVENKLQPG---RAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVV 2543

  Fly   679 ASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEIPVTVVQPHVL 743
            :...:....:.:...|.:.:::.:.       |..|..::       :.|:|.:..:.:.:
Human  2544 SDNVFHIQWSLISFKYTSYNVSEKA-------GSVSVTVQ-------RTGNLNQYAIVLCR---- 2590

  Fly   744 ESDQNTPVFEPASSKGDNSVEFQPNTIQRDF------ILVPERATWAELRMRITDPNRGEDIGKF 802
             ::|.|     |||  .:.|..||.  |:|:      :...||.......:.|.|.:..|::..|
Human  2591 -TEQGT-----ASS--SSRVSSQPG--QQDYVEYAGQVQFDEREDTKSCTIVINDDDVFENVESF 2645

  Fly   803 FVHTNQLLPKQS-CRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRF 866
            .|..:  :|..: ..:....|::...:|:|..:.|..|.          ||.|.....|...:..
Human  2646 TVELS--MPAYALLGEFTQAKVIINDTEDEPTLEFDKKI----------YWVNESAGFLFAPIER 2698

  Fly   867 RG--------------VEAHNPNAYVMHAG-----RGI--------------------------- 885
            :|              ..|...:.|.:.:|     ||:
Human  2699 KGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEY 2763

  Fly   886 ---HKLEIEALVAEDVQPQLQLKNAEVVLK-PTEA-------------------KI--------- 918
               .:.||....|.|.....::..|:|::. |.:|                   ||
Human  2764 EEEEEFEIALADASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPVIRHGTDL 2828

  Fly   919 -------------SPLSATR--DVIPDGRQ-----------------------VYQNLLAFNLNV 945
                         .|.|||.  |.:|..|:                       |.:.|..|.:.:
Human  2829 STFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFL 2893

  Fly   946 AKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSHTSFTKLDKGEYTIRLQVRHE 1010
            :.|....:..|....:.....|:....|.|..:..||...:...|...|:  .|:.:....||..
Human  2894 SSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITR--SGDLSYESSVRCY 2956

  Fly  1011 KRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSSPLRLSTRVLYIAPITQERLTK 1075
            .:....::.|               ||.|..|..              |:|:.::         |
Human  2957 TQSHSAQVME---------------DFEERQNAD--------------SSRITFL---------K 2983

  Fly  1076 ANLPAQC-AWLSGNLVFPQDEVGRRVAQHPFTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTT 1139
            .:....| .::..:.:|..:|..|       .|:..|.  .:|.:|:..|.:      ..|.:|.
Human  2984 GDKVKNCTVYIHDDSMFEPEEQFR-------VYLGLPL--GNHWSGARIGKN------NMATITI 3033

  Fly  1140 ANGAKPKAPATPQAATSVTNPAAGDGISVQNDPPVDSSGSPASPKKGKANADDYAESFRDF 1200
            :|..........:||..|..||..|.|::.|...:.......:.|...:..|..|:|..|:
Human  3034 SNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDY 3094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	85/483 (18%)
		Peptidase_S8	331..600	CDD:278510	58/339 (17%)
		TPPII	892..1073	CDD:289357	37/247 (15%)
		TPPII_N	1144..1257	CDD:289360	13/57 (23%)
FRAS1	NP_079350.5	VWC	28..87	CDD:214564
		VWC	95..152	CDD:278520
		VWC	159..216	CDD:278520
		VWC	221..278	CDD:278520
		VWC	285..342	CDD:214564
		VWC	367..416	CDD:214564
		FU 1	409..460
		Furin-like	462..620	CDD:279142
		FU 2	462..505
		FU	462..504	CDD:214589
		FU 3	507..553
		FU	507..552	CDD:214589
		FU 4	555..599
		FU	556..598	CDD:214589
		FU 5	602..647
		FU	608..653	CDD:238021
		FU 6	649..705
		FU	650..704	CDD:214589
		GF_recep_IV	655..777	CDD:291509
		FU 7	708..753
		FU	708..752	CDD:214589
		FU 8	755..800
		FU	755..799	CDD:214589
		FU 9	803..852
		FU	804..851	CDD:214589
		Furin-like	841..1056	CDD:279142
		FU 10	854..900
		FU	859..907	CDD:238021
		FU 11	903..948
		FU 12	952..997
		FU	952..996	CDD:214589
		FU 13	999..1042
		FU	999..1041	CDD:214589
		Furin-like_2	1009..1099	CDD:292535
		FU 14	1046..1089
		FU	1046..1087	CDD:214589
		Cadherin_3	<1101..1183	CDD:292802
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1102..1197
		Cadherin_3	1168..1310	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1217..1308
		Cadherin_3	1279..1438	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1329..1438
		Cadherin_3	1409..1574	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1463..1559
		Cadherin_3	1529..1691	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1595..1689
		Cadherin_3	1660..1811	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1710..1810
		Cadherin_3	1778..1938	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1833..1936
		Cadherin_3	1904..2059	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1957..2057
		Cadherin_3	2028..2179	CDD:292802	30/150 (20%)
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2078..2177		26/137 (19%)
		Cadherin_3	2147..2293	CDD:292802	27/154 (18%)
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2199..2291		15/92 (16%)
		Cadherin_3	2261..2406	CDD:292802	25/168 (15%)
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2311..2404		14/105 (13%)
		Cadherin_3	2375..2537	CDD:292802	37/205 (18%)
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2439..2536		24/133 (18%)
		Calx_beta	2555..2650	CDD:197594	22/122 (18%)
		Calx-beta	2675..2764	CDD:295344	12/98 (12%)
		Calx-beta	2798..2894	CDD:295344	13/95 (14%)
		Calx-beta	2920..3011	CDD:295344	22/137 (16%)
Calx-beta	3039..3133	CDD:295344	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900