DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and TPP2

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	XP_005254127.1	Gene:	TPP2 / 7174	HGNCID:	12016	Length:	1304	Species:	Homo sapiens

Alignment Length:	1436	Identity:	502/1436 - (34%)
Similarity:	759/1436 - (52%)	Gaps:	214/1436 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 MATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGLETLCDGKTVKV 152
            |||:...|.||...|:||.|||..:||.:|||||||.|.||:.|:||||.|.|::...|||. |:
Human     1 MATAATEEPFPFHGLLPKKETGAASFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKP-KI 64

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGLKSFSDLLPSK 217
            ::..|.:|.|||:...:|.| ::|.|.||||..||:.    |..|:|.....:|:|:..|..|..
Human    65 VDIIDTTGSGDVNTATEVEP-KDGEIVGLSGRVLKIP----ASWTNPSGKYHIGIKNGYDFYPKA 124

  Fly   218 VRNNIVAQAKLKHWDKPHKTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEMLNSYE 282
            ::..|..:.|.|.||..|:.|.|.|.||..||:..|.|.:..    .|::||.|..::|:|||:|
Human   125 LKERIQKERKEKIWDPVHRVALAEACRKQEEFDVANNGSSQA----NKLIKEELQSQVELLNSFE 185

  Fly   283 KVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHE--TRNVDDFLSISVNVHD 345
            |.|.|....|||:::...:.|...:|:.|.|||.::..:..|....|  :....:.|:.|||::|
Human   186 KKYSDPGPVYDCLVWHDGEVWRACIDSNEDGDLSKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYD 250

  Fly   346 EGNVLEVVGMSSPHGTHVSSIASGNHSSR-DVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMT 409
            :||:|.:|.....|||||:|||:|:.... :.:||||.|:|:|:.|||.||.:|||||.|:|||.
Human   251 DGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMI 315

  Fly   410 KVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPPD 474
            :|:     ..:.|::|.||||..:|.|||||.|::||.|.|:.:::|:||||:||.|.|||.|..
Human   316 EVI-----NHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNIIYVSSAGNNGPCLSTVGCPGG 375

  Fly   475 ISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTM 539
            .:. |:|||||||||.||.|||::|||||.|.|||:||.|..||..||::.||||||||||.:|:
Human   376 TTS-SVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTL 439

  Fly   540 SKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNV 604
            ..:||||||||::|:..|.:||::||||..||:|:.:|::||:..||.|...::.||||||::.|
Human   440 RGTQLMNGTSMSSPNACGGIALILSGLKANNIDYTVHSVRRALENTAVKADNIEVFAQGHGIIQV 504

  Fly   605 EKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQ-RNSIDYNVYIEPIFYNDKEADPKDK 668
            :||:::|.:: .|..|.|.|:|.||||  :||:||..|| ....|:.|.|||:|  .:..:..:|
Human   505 DKAYDYLVQN-TSFANKLGFTVTVGNN--RGIYLRDPVQVAAPSDHGVGIEPVF--PENTENSEK 564

  Fly   669 FNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEI 733
            .:..:.|.|.::..||||.:.|:|....|.|.:||||.||:.|:|...:..||......|.||.:
Human   565 ISLQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRV 629

  Fly   734 PVT-VVQPHVLESDQNTPVFEPASSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGE 797
            |:| |:...|.||......|        ..|.|:|..|:|.||.|||.|||||:.:....   .|
Human   630 PITAVIAAKVNESSHYDLAF--------TDVHFKPGQIRRHFIEVPEGATWAEVTVCSCS---SE 683

  Fly   798 DIGKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKY 862
            ...||.:|..||:.:::.|..|..|..|:..:.....||.|..|:.:|.|||::|::....::.|
Human   684 VSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLTEAFPVLGGKAIEFCIARWWASLSDVNIDY 748

  Fly   863 SLRFRGVEAHNPNAYVMHAGRGIHKLEIE-ALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRD 926
            ::.|.|:....|...: ||..||::.::: :|..||:.|.:.|||....|:|..||..|| .:||
Human   749 TISFHGIVCTAPQLNI-HASEGINRFDVQSSLKYEDLAPCITLKNWVQTLRPVSAKTKPL-GSRD 811

  Fly   927 VIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSHT 991
            |:|:.||:|:.:|.:|.:..|:.:|:...|:..:||||:||:||:|::||.||..:.:|||:.|.
Human   812 VLPNNRQLYEMVLTYNFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQ 876

  Fly   992 SFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSSPL 1056
            ...||:||:||||||:|||:...||::.:...:.|.:|::.|:||.:||::..::|.:|  ||.|
Human   877 YSLKLEKGDYTIRLQIRHEQISDLERLKDLPFIVSHRLSNTLSLDIHENHSFALLGKKK--SSNL 939

  Fly  1057 RLSTRV---LYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQH-------------PF 1105
            .|..:.   .::..:..:::.|...|.  .:|:|:|...:.|:|::..|.             |.
Human   940 TLPPKYNQPFFVTSLPDDKIPKGAGPG--CYLAGSLTLSKTELGKKAGQSAAKRQGKFKKDVIPV 1002

  Fly  1106 TYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQN 1170
            .|.|.|...|                       |.||:|
Human  1003 HYYLIPPPTK-----------------------TKNGSK-------------------------- 1018

  Fly  1171 DPPVDSSGSPASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANLLLI 1235
            |...||       :|.|...:::.|:.||.:...:.|.:   :..|||::...:|.:|...:..:
Human  1019 DKEKDS-------EKEKDLKEEFTEALRDLKIQWMTKLD---SSDIYNELKETYPNYLPLYVARL 1073

  Fly  1236 QNIESNQLKSQLPLTFVNAQKTSPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSEALL 1300
            ..:                            |.:||..|:    |..||..|:.||...|..||.
Human  1074 HQL----------------------------DAEKERMKR----LNEIVDAANAVISHIDQTALA 1106

  Fly  1301 SYYGLKNDTRADAAKIK------------------------------------------TNMDKQ 1323
            .|..:|.|.|.|||.||                                          ::||||
Human  1107 VYIAMKTDPRPDAATIKKLPSDFCIIPALLWAARIHQAAFAESALQTLAERRMKGVLRHSDMDKQ 1171

  Fly  1324 KNTLIEALSKKGIAVA----KLAVLDDCIK--------------DSLAEINELYTEIIKFVDAND 1370
            |:||::||.:||.|:|    .....|..|.              ||||   |.:.|..|:.|..|
Human  1172 KSTLVDALCRKGCALADHLLHTQAQDGAISTDAEGKEEEGESPLDSLA---ETFWETTKWTDLFD 1233

  Fly  1371 SKAIQFALWHAYAHGHYGRMYKYVVKLIEEKRTRDHFVELAAINGALGHEHIRTVINRMMITAFP 1435
            :|.:.||..||..:..|||..|:..||:|||.|::::.....:...||..|..:.....:...:|
Human  1234 NKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYP 1298

  Fly  1436 SSFRLF 1441
            ..:.:|
Human  1299 PDYCVF 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	224/490 (46%)
		Peptidase_S8	331..600	CDD:278510	140/269 (52%)
		TPPII	892..1073	CDD:289357	70/183 (38%)
		TPPII_N	1144..1257	CDD:289360	15/112 (13%)
TPP2	XP_005254127.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	224/490 (46%)
TPP2	XP_005254127.1	TPPII	777..960	CDD:378883	70/185 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159945
Domainoid	1	1.000	410	1.000	Domainoid score	I683
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2471
Inparanoid	1	1.050	816	1.000	Inparanoid score	I477
Isobase	1	0.950	-	0	Normalized mean entropy	S4793
OMA	1	1.010	-	-		QHG58290
OrthoDB	1	1.010	-	-		D156304at2759
OrthoFinder	1	1.000	-	-		FOG0005779
OrthoInspector	1	1.000	-	-		oto91199
orthoMCL	1	0.900	-	-		OOG6_104037
Panther	1	1.100	-	-	LDO	PTHR43806
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1540
SonicParanoid	1	1.000	-	-		X4170
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750