DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and pcsk5a

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:XP_003198725.3 Gene:pcsk5a / 571235 ZFINID:ZDB-GENE-060531-130 Length:1867 Species:Danio rerio


Alignment Length:726 Identity:137/726 - (18%)
Similarity:224/726 - (30%) Gaps:284/726 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   282 EKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHETRNVDDFLSISVNVHDE 346
            |:.:.|:|.:||.......:|          .|.|...|   |..|:|.:               
Zfish   162 ERQHPDLKQNYDARASYDVNG----------NDPDPTPR---YDVTNENK--------------- 198

  Fly   347 GNVLEVVGMSSPHGTHVSSI--ASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMT 409
                        |||..:.:  ||.|:|...| |:|.||||..:.:.||.:      |.:|.|.:
Zfish   199 ------------HGTRCAGVVAASANNSLCIV-GIAYNAKIGGVRMLDGDM------TDMVEAQS 244

  Fly   410 KVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPPD 474
                |....:.||:.:.|:|.    .:.||                            ||..|..
Zfish   245 ----LNLRQQYIDIYSSSWGP----DDDGR----------------------------TVDGPGP 273

  Fly   475 ISQPSLIGVGAYVSPQMMEAEYAMRE--KLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQF 537
            :::.:|              |..:|:  |..|:::.|.|.    :|||....|:..|...|:  :
Zfish   274 LARLAL--------------ENGIRKGRKGRGSIFVWASG----NGGQSQDHCSCDGYTNSI--Y 318

  Fly   538 TMS-----------------KSQLM--------------------------NGTSMAAPHVAGAV 559
            |:|                 .|.|.                          :|||.:||..||.:
Zfish   319 TISVGSTTQSGRKPWYLEECSSTLATTYSSGDSHSPGVVTTDLRQRCTDEHSGTSASAPMAAGII 383

  Fly   560 ALLISGLKQQNIEYSPYSIKRAISVTATK------------LGYVDPFAQGHGLLNVEKAFEHLT 612
            ||.:    :.|...:...|:..|..|:::            .||......|.||||.|...::..
Zfish   384 ALTL----EANPALTWRDIQHIIVKTSSRGHLSASDWQSNGAGYDVSHLYGFGLLNAEAMVKNAE 444

  Fly   613 EHRQSKDNMLRFSVRVGNNAD--------KGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKF 669
            ..:|.....: ....:|.||.        :.:....|.....:...||:|.:........| .:.
Zfish   445 TWKQVPSQHI-CEENIGQNARIISPERVLRSVLKSSGCSAQRLQRVVYLEHVIVRVTITHP-HRG 507

  Fly   670 NFNVRL--------NLIASQP------------------WVQCGA---FLDLS------------ 693
            :.::.|        .|:|::|                  |.:..|   .||:.            
Zfish   508 DLSITLTSPSGTTSQLLANRPNDHSSEGFIKWEFMTTHCWGERSAGDWILDIRDTPSPQRNTRLQ 572

  Fly   694 ----------YGTRSIA-VRVD-PTGLQPGVHSAVIRAY----DTDCVQKGSLFEIPVTVVQPH- 741
                      |||.:.. :|.: |...|......:...|    |.:|.:.|.  |.|    .|| 
Zfish   573 GKLVEWSLVLYGTSTHPYIRHEQPRSAQLPSEDEITEEYNGSCDPECSEDGC--EGP----GPHQ 631

  Fly   742 ---------VLESDQNTPVFE-PASSKGD---------------NSVEFQPNTIQRDFILVPERA 781
                     ..:::..|.|.| |:...||               .|...|..|.:..:.|..|:.
Zfish   632 CVSCLNLFLKFKNNTRTCVSECPSGYWGDKKRCKKCYSSCKSCLGSRSDQCTTCKSGYHLNEEKN 696

  Fly   782 TWAELRMRITDPNRGEDIGKFFVHTNQLLPK---QSCRKLETMKIVSVGSENESIMAFKVKSGRI 843
            ...         ...|| |.|..|...:..|   ::|.|..:..|.:..||..|::     ..|.
Zfish   697 NCV---------TSCED-GYFLYHEENMCRKCNIENCMKCTSASICTECSEGTSLV-----GNRC 746

  Fly   844 LELC-IAKYWS 853
            .:.| :..|:|
Zfish   747 QKSCEVGSYYS 757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 71/365 (19%)
Peptidase_S8 331..600 CDD:278510 62/327 (19%)
TPPII 892..1073 CDD:289357
TPPII_N 1144..1257 CDD:289360
pcsk5aXP_003198725.3 S8_pro-domain 29..104 CDD:318632
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 116..406 CDD:173789 70/350 (20%)
P_proprotein 492..582 CDD:307572 10/90 (11%)
FU 615..726 CDD:320742 25/126 (20%)
VSP 682..1073 CDD:333463 19/91 (21%)
VSP 1019..>1277 CDD:333463
Furin-like_2 1274..1341 CDD:318185
FU 1402..1448 CDD:238021
FU 1453..1565 CDD:320742
FU 1550..1599 CDD:238021
FU 1596..1639 CDD:214589
FU 1649..1686 CDD:214589
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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