Protein Alignment TppII and furinb

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: XP_073798271.1
• Gene: furinb / 566591
• ZFINID: ZDB-GENE-040901-2
• Length: 843
• Species: Danio rerio
• Alignment Length: 584
• Identity: 110/584 - (18%)
• Similarity: 189/584 - (32%)
• Gaps: 204/584 - (34%)

  Fly   287 DIKTSYDCILFPTADGWLTIVDTTEQG---------DLDQALRIGEYSRTHETRNVDDFLSISVN 342
            |.|......|:..:.|.|.:.:...||         .||..:   |.......:|.|...|..||
Zfish   116 DPKFPQQWYLYNPSHGDLNVKEAWAQGFTGRGVVVTILDDGI---EKDHPDLAKNYDPDASYDVN 177

  Fly   343 VHDEGNVLEVVGMS-SPHGTHVSS--IASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTAL 404
            ..|.........:: :.|||..:.  .|:.|:....| |||.||||..:.:.||.:      |.:
Zfish   178 DRDPDPQPRYTQLNDNRHGTRCAGEVAAAANNGVCGV-GVAYNAKIGGVRMLDGEV------TDV 235

  Fly   405 VRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTV 469
            |.|.:    |..:.:.|.:.:.|:|.    .:.|:                            ||
Zfish   236 VEAQS----LSLNSQHIHIYSASWGP----EDDGK----------------------------TV 264

  Fly   470 GTPPDISQPSLI-GVGAYVSPQMMEAEYAMREKLPGNVYTWTS------RDPCIDGGQGVTVCAP 527
            ..|..:::.:.: ||        .|....:     |:::.|.|      ||.|  ...|.|....
Zfish   265 DGPAKLAKEAFLQGV--------TEGRSGL-----GSIFVWASGNGGRERDSC--NCDGYTNSIY 314

  Fly   528 GGAIASVPQF---------------------TMSKSQLM-------------------------- 545
            ..:|:|..|:                     .:::.|::
Zfish   315 TLSISSTTQYGSVPWYSEACSSTLATTYSSGNLNEKQIVCISHTFRCAFILQLYLCVQVTTDLRK 379

  Fly   546 ------NGTSMAAPHVAGAVALLIS---GLKQQNIEYSPYSIKRAISVTATK-----LGYVDPFA 596
                  .|||.:||..||.:||.:.   .|..:::::......|...:....     :|.:...:
Zfish   380 KCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSRPAHLITNDWRTNGVGRLVSHS 444

  Fly   597 QGHGLLNVEKAF-----------EH------LTEHRQSKDNMLRFSVRV---GNNADKGIHLRQG 641
            .|:|||:.....           :|      |||.|..|.: |.||..|   ....|....|...
Zfish   445 YGYGLLDATAMVALAQNWTSMGPQHKCVINMLTEPRDIKSH-LTFSRSVEACSGQPDFVSSLEHV 508

  Fly   642 VQRNSIDYN------VY-IEPI-----------------FYND--------KEADPKDKFNFNVR 674
            ..|.::.||      |: |.|:                 .:||        .:.||:.::...:.
Zfish   509 QARLTLSYNHRGNLAVHLISPLGTRSTLLAPRPQDNSAEGFNDWAFMTTHSWDEDPRGEWTLEIE 573

  Fly   675 LNLIASQPWVQCGAFLDLSYGTRSIAVRVDPT---GLQPGVHSAVIRAYDTD--CVQKGSLFEI 733
             |:.....:.....|..:.|||.|.|  .||:   ..:|..:|.  :.:||.  |::..:.|.:
Zfish   574 -NVAGLNDYGVLSQFTLILYGTGSSA--TDPSVSDYTRPSNNSC--KTFDTQQICIECSTGFSL 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	68/381 (18%)
		TPPII	892..1077	CDD:463636
		TPPII_N	1144..1257	CDD:403697
furinb	XP_073798271.1	None