DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and PCSK4

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	XP_011526387.1	Gene:	PCSK4 / 54760	HGNCID:	8746	Length:	782	Species:	Homo sapiens

Alignment Length:	603	Identity:	125/603 - (20%)
Similarity:	195/603 - (32%)	Gaps:	189/603 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 NTDPEKAVR-VGLKSFSDLLPS----KVRN-NIVAQAKLKHWDKPHK------TATANASRKIVE 248
            |.:.|:..| .|..:...:.|.    .:|: .:|.|:...||.  |:      ..|....:.|.:
Human    46 NREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWG--HRLHLKKNPKTRPGPKSIQQ 108

  Fly   249 FESQNP-----GEASKL-PWDKKILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGW---- 303
            .|:..|     |....| .|          |:.:.|..      .:|.|   ::.|| |.|
Human   109 EEAGRPRYGNHGACQGLVQW----------FQQQTLQR------RVKRS---VVVPT-DPWFSKQ 153

  Fly   304 ----------LTIVDTTEQGDLDQALRIG------EYSRTHETRNVDDFLSISVNVHD-EGNVLE 351
                      |:|:....||...|.:.:.      |........|.|...|...|.:| :.....
Human   154 WYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRY 218

  Fly   352 VVGMSSPHGTHVSS--IASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVMEL 414
            .....:.|||..:.  .|..|:....| |||.||:|..:.:.||      |.|.::.|.:    |
Human   219 TPSKENRHGTRCAGEVAAMANNGFCGV-GVAFNARIGGVRMLDG------TITDVIEAQS----L 272

  Fly   415 CRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNK--------YGVVWVASAGNHGPALCTVGT 471
            ....:.|.:.:.|:|...:.......|.|..|...:        .|.:::.::||.|........
Human   273 SLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNC 337

  Fly   472 PPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQ 536
            ....:....:.||:          ...:.::|     |.| :.|   ...:|.....| :|:.||
Human   338 DGYTNSIHTLSVGS----------TTQQGRVP-----WYS-EAC---ASTLTTTYSSG-VATDPQ 382

  Fly   537 FTMSK-----SQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAIS---VTATK----- 588
            ...:.     :....|||.:||..||.:||.        :|.:|:...|.:.   |.|:|
Human   383 IVTTDLHHGCTDQHTGTSASAPLAAGMIALA--------LEANPFLTWRDMQHLVVRASKPAHLQ 439

  Fly   589 --------LGYVDPFAQGHGLLN----VEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQG 641
                    :|.......|:|||:    |:.|...|....|.|     .:|||.:....
Human   440 AEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRK-----CAVRVQSRPTP------- 492

  Fly   642 VQRNSIDYNVYIEPIFYNDKEADPKDKFNFNVRL-----NLIASQPWVQCGAFLDLSY------- 694
                       |.|:.|          ...||..     |.|.|...||  |.|.|||
Human   493 -----------ILPLIY----------IRENVSACAGLHNSIRSLEHVQ--AQLTLSYSRRGDLE 534

  Fly   695 -------GTRSIAVRVDP 705
                   ||||..|.:.|
Human   535 ISLTSPMGTRSTLVAIRP 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	91/462 (20%)
		Peptidase_S8	331..600	CDD:278510	61/300 (20%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
PCSK4	XP_011526387.1	S8_pro-domain	37..140	CDD:293079	20/111 (18%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	145..434	CDD:173789	68/328 (21%)
		Peptidase_S8	176..459	CDD:278510	63/321 (20%)
		P_proprotein	516..602	CDD:279782	13/39 (33%)
		FU	674..711	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900