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Protein Alignment TppII and Furin

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_062204.2	Gene:	Furin / 54281	RGDID:	3274	Length:	793	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	111/547 - (20%)
Similarity:	175/547 - (31%)	Gaps:	157/547 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 NVDDFLSISVNVHDEGNVLEVVGMS-SPHGT----HVSSIASGNHSSRDVDGVAPNAKIVSMTIG 391
            |.|...|..||..|.........|: :.|||    .|:::|  |:....| |||.||:|..:.:.
  Rat   166 NYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVA--NNGVCGV-GVAYNARIGGVRML 227

  Fly   392 DGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNK------ 450
            ||.:      |..|.|.:    |..:...|.:.:.|:|...:.........|..|...:
  Rat   228 DGEV------TDAVEARS----LGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGR 282

  Fly   451 --YGVVWVASAGN----HGPALCTVGTPP----DISQPSLIGVGAYVS---PQMMEAEYAMREKL 502
              .|.::|.::||    |....|...|..    .||..:..|...:.|   ...:...|:...:.
  Rat   283 GGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQN 347

  Fly   503 PGNVYTWTSRDPCIDGGQGVTVCAP--GGAIA---------------------SVPQFTMSKSQL 544
            ...:.|...|..|.:...|.:..||  .|.||                     |.|....:....
  Rat   348 EKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWA 412

  Fly   545 MNGTSMAAPHV-------AGAVALL------ISGLKQQNIEY--SPYSIKRAISVTATK---LGY 591
            .||......|.       |||:..|      ::..::..||.  .|..|.:.:.|..|.   ||
  Rat   413 TNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLG- 476

  Fly   592 VDPFAQGHGLLNVEKAFEHLT--EHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSI------- 647
             :|              .|::  ||.|:     |.::......|..|||...:...|.
  Rat   477 -EP--------------NHISRLEHVQA-----RLTLSYNRRGDLAIHLISPMGTRSTLLAARPH 521

  Fly   648 DYNVYIEPIFYND--------KEADPKDKFNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVD 704
            ||:.    ..:||        .:.||..::...:. |...:..:.....|..:.|||.|..:...
  Rat   522 DYSA----DGFNDWAFMTTHSWDEDPSGEWVLEIE-NTSEANNYGTLTKFTLVLYGTASEGLSAP 581

  Fly   705 P--TGLQPGVHSAV-------IRAYDTDCVQK---GSLFEIPVTVVQPHVLESDQNTPVFEPASS 757
            |  :|.:....|..       ...:...|||:   |         ..|.||::..:|
  Rat   582 PESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPG---------FTPQVLDTHYST-------- 629

  Fly   758 KGDNSVEFQPNTIQRDFILVPERATWA 784
              :|.||     |.|..:..|..|:.|
  Rat   630 --ENDVE-----IIRASVCTPCHASCA 649

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.