Protein Alignment TppII and PCSK2

DIOPT Version :9

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: NP_002585.2
• Gene: PCSK2 / 5126
• HGNCID: 8744
• Length: 638
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 92/478 - (19%)
• Similarity: 160/478 - (33%)
• Gaps: 190/478 - (39%)

  Fly   359 HGT----HVSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVME---LCR 416
            |||    .||:.|:.|...   .|||.|:|:..:.:.|...            ||.::|   :..
Human   208 HGTRCAGEVSAAANNNICG---VGVAYNSKVAGIRMLDQPF------------MTDIIEASSISH 257

  Fly   417 DGRRIDVINMSYGEHANWSNSGRIGEL----MNEVVNK----YGVVWVASAGNHGPALCTVGTPP 473
            ..:.||:.:.|:|...|........||    |.:.|||    .|.::|.::|:.       |:..
Human   258 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDG-------GSYD 315

  Fly   474 DISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWT-SRDPCIDGGQGVTV---CAPGGAIASV 534
            |.:      ...|.|..                  || |.:..|:.|:....   |:  ..:||.
Human   316 DCN------CDGYASSM------------------WTISINSAINDGRTALYDESCS--STLAST 354

  Fly   535 --------PQFTMSKSQLM-------NGTSMAAPHVAGAVALLIS---GLKQQNIEYSPYSIKRA 581
                    |:..::.:.|.       :|||.|||..||..||.:.   ||..:::::
Human   355 FSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQH-------- 411

  Fly   582 ISVTATKLGYV-DPFAQ--------------GHGLLN-------------VEKAFEHL------- 611
            ::|..:|...: |...|              |:|:|:             |.:.|..:
Human   412 LTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDP 476

  Fly   612 --------------TEHRQSKDNMLRF--------SVRVGNNADKGIHLRQGVQRNSIDYNVYIE 654
                          |:..:.|:|.:|:        :|......|..|::...:...||
Human   477 EKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSI------- 534

  Fly   655 PIFYNDKEADPK---DKFNF--------------NVRLNLIASQPWVQCGAFLD---LSYGTRSI 699
            .:....::.|.|   ||:.|              .:.|..:.|.|  |.|...:   :.:||:|
Human   535 LLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAP--QKGVLKEWTLMLHGTQS- 596

  Fly   700 AVRVDPTGLQPGVHSAVIRAYDT 722
            |..:|          .|:|.|.:
Human   597 APYID----------QVVRDYQS 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	57/266 (21%)
		Peptidase_S8	331..600	CDD:278510	61/292 (21%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
PCSK2	NP_002585.2	S8_pro-domain	33..109	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	122..418	CDD:173789	57/265 (22%)
		Peptidase_S8	158..435	CDD:278510	60/282 (21%)
		P_proprotein	504..591	CDD:279782	15/95 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900