DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TppII and FURIN

DIOPT Version :10

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_002560.1 Gene:FURIN / 5045 HGNCID:8568 Length:794 Species:Homo sapiens


Alignment Length:570 Identity:109/570 - (19%)
Similarity:176/570 - (30%) Gaps:209/570 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   359 HGTHVSSIASG---NH----------SSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTK 410
            ||..||.:..|   ||          :|.||:...|:.:.....:.|.|.|:...|.....|...
Human   145 HGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG 209

  Fly   411 VMELCRDG----RRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPA--LCTV 469
            |   |..|    .||..:.|..||..:...:..:|...|. ::.|...|       ||.  ..||
Human   210 V---CGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNH-IHIYSASW-------GPEDDGKTV 263

  Fly   470 GTPPDISQPSLI-----GVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGG 529
            ..|..:::.:..     |.|..                 |:::.|.|.    :||:....|...|
Human   264 DGPARLAEEAFFRGVSQGRGGL-----------------GSIFVWASG----NGGREHDSCNCDG 307

  Fly   530 --------AIASVPQF---------------------TMSKSQLM------------NGTSMAAP 553
                    :|:|..||                     ..::.|::            .|||.:||
Human   308 YTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAP 372

  Fly   554 HVAGAVALLISGLKQ---QNIEYSPYSIKRAISVTATK-----LGYVDPFAQGHGLL-------- 602
            ..||.:||.:...|.   :::::......:...:.|..     :|.....:.|:|||        
Human   373 LAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVAL 437

  Fly   603 ----------------------NVEKAFE-------------HLT--EHRQSKDNMLRFSVRVGN 630
                                  ::.|..|             |:|  ||.|:     |.::....
Human   438 AQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQA-----RLTLSYNR 497

  Fly   631 NADKGIHLRQGVQRNSI-------DYNVYIEPIFYND--------KEADPKDKFNFNVRLNLIAS 680
            ..|..|||...:...|.       ||:.    ..:||        .:.||..::...:. |...:
Human   498 RGDLAIHLVSPMGTRSTLLAARPHDYSA----DGFNDWAFMTTHSWDEDPSGEWVLEIE-NTSEA 557

  Fly   681 QPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTD--CV---------QKGSLFEIP 734
            ..:.....|..:.|||.       |.||.....|:..:...:.  ||         ||..:...|
Human   558 NNYGTLTKFTLVLYGTA-------PEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCP 615

  Fly   735 VTVVQPHVLESDQNTPVFEPASSKGDNSVEFQPNTIQRDFILVPERATWA 784
            .... |.||::..:|          :|.||    || |..:..|..|:.|
Human   616 PGFA-PQVLDTHYST----------ENDVE----TI-RASVCAPCHASCA 649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 58/302 (19%)
TPPII 892..1077 CDD:463636
TPPII_N 1144..1257 CDD:403697
FURINNP_002560.1 S8_pro-domain 33..107 CDD:465126
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 113..402 CDD:173789 57/288 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..183 4/20 (20%)
P_proprotein 484..570 CDD:460225 17/95 (18%)
Cell attachment site. /evidence=ECO:0000255 498..500 0/1 (0%)
FU 1. /evidence=ECO:0000255 577..620 8/43 (19%)
FU 581..618 CDD:214589 6/36 (17%)
FU 2. /evidence=ECO:0000255 638..681 3/12 (25%)
FU 638..>675 CDD:214589 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Cell surface signal. /evidence=ECO:0000303|PubMed:9412467 759..762
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..794
Trans Golgi network signal. /evidence=ECO:0000269|PubMed:8846780 773..779
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.