Protein Alignment TppII and S1P

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Alignment Length: 882
• Identity: 166/882 - (18%)
• Similarity: 312/882 - (35%)
• Gaps: 285/882 - (32%)

  Fly   326 RTHET--RNVDDFLSISVNVHDEGNVLEVVGMSSPHGTHVSSIASGNHSSRDVDGVAPNAKIVSM 388
            ||:.|  :::||.:|                    |||.|:.:.:   |||:..|.||:|.:...
  Fly   185 RTNWTNEKSLDDRVS--------------------HGTFVAGVIA---SSRECLGFAPDADLYIF 226

  Fly   389 TIGDGRLGSMETGTALVRAMTKVMELCRDG------RRIDVINMSYGEHANWSNSGRIGELMNEV 447
            .:             ...:.........|.      |:|:::|:|.| ..::.:|..:.:::...
  Fly   227 KV-------------FTNSQVSYTSWFLDAFNYAIYRKINILNLSIG-GPDFMDSPFVEKVLELS 277

  Fly   448 VNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSR 512
            .|  .|:.:::|||.||...|:..|.|  |..::|||.......: |:::.|     .:.||..
  Fly   278 AN--NVIMISAAGNDGPLYGTLNNPGD--QSDVVGVGGIQFDDKI-AKFSSR-----GMTTWEL- 331

  Fly   513 DPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEY-SPY 576
             |...|..|:.:...|..:..  .......:.::|||:::|.||||.||||||..|: |:| :|.
  Fly   332 -PLGYGRMGLDIVTYGSQVEG--SDVRKGCRRLSGTSVSSPVVAGAAALLISGAFQK-IDYINPA 392

  Fly   577 SIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQ-----------SKDNMLRFSVRVGN 630
            |:|:.:...|.||.:.:.|.||.|.||:.|:.:.|..::.           :::.|..:|
  Fly   393 SLKQVLIEGAEKLPHYNMFEQGAGKLNLLKSMQLLLSYKPKITLIPAYLDFTQNYMWPYS----- 452

  Fly   631 NADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKF--NFNVRLNLIASQPWV----QCGAF 689
                                  .:|::|....|......  ..:|..:::....|:    ..|.|
  Fly   453 ----------------------SQPLYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQGQF 495

  Fly   690 LDLS----------YGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGS----LFEIPVTVVQP 740
            |.:|          .|..|:.:.|...|          ..::..|  |||    |.....|..:.
  Fly   496 LQVSAQVSPIVWPWTGWMSVFIAVKKEG----------ENFEGVC--KGSITLVLESFKQTTNET 548

  Fly   741 HVLESD-----QNTPVFEPASSK-----GDNSVEFQPNTIQRDFILVP--------------ERA 781
            ||.|.|     :.||  :|..:|     ..:|:.:.|..|.||.:.|.              .|.
  Fly   549 HVTEVDFPLTIKVTP--KPPRNKRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWRADHIHTNFRD 611

  Fly   782 TWAELR-----------------------MRITDPNRG---EDIG-------------------- 800
            .:..||                       :.|.||.||   |:|.
  Fly   612 MYTHLRNVGYYIDVLREPFTCFNASDYGALLIVDPERGFGDEEINALQENVYKRGLNVVVFGDWY 676

  Fly   801 --------KFFVHTNQLLPKQSCRKLETMKI--VSVGSENESIMAFKVKSGRIL----------- 844
                    |||        .::.|:..|...  .::.:.|:.:..|.:..|..:
  Fly   677 NTTVMKKIKFF--------DENTRQWWTPDTGGANIPALNDLLKPFGIAFGDFVGEGHFKLGDHS 733

  Fly   845 -----ELCIAKYWSNYGQSHLKYSLRFRG---VEAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQ 901
                 ...|.|:..|.|...:...|..:|   :.:..|:.        :.||::........:..
  Fly   734 MYYASGATIVKFPMNPGDIIVGTKLNDQGLSIINSKTPSK--------VAKLDVPIFGMFQTKAN 790

  Fly   902 LQLKNAEVVLKPTEAKISPLSATRDVIPDGRQVYQNLLAF------NLNVAKAAD--------VS 952
            ....|.|:|:. .|:.::      :.||.....::|.:..      :::.||:.:        ::
  Fly   791 SIQSNEEIVVN-AESNLA------EAIPTDYSTFKNRVLLLRTKQRSISFAKSNNHETKNEGRIA 848

  Fly   953 IYAPIFNDLLYEAEFESQ-MWML-------FDANKALVATGDAHSHTSFTKLDKGEYTIRLQVRH 1009
            :|..  ::.|.....|.. .|:|       .:::|:.:.. :.:..|.|.||::....:|:
  Fly   849 VYGD--SNCLDSTHLEKACYWLLITFLDFAINSHKSSLLQ-NLNRITEFHKLERAPLPLRI---- 906

  Fly  1010 EKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIV 1046
             .:.:::..|:.|....||..:|...:..|.....|:
  Fly   907 -SQSIIKSRSQDNNCEQFKWLAPTKQNNAEERKSSII 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	67/271 (25%)
		TPPII	892..1077	CDD:463636	27/177 (15%)
		TPPII_N	1144..1257	CDD:403697
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	69/273 (25%)
		DUF4350	610..754	CDD:464118	22/151 (15%)