DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and Pcsk9

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_954862.2	Gene:	Pcsk9 / 298296	RGDID:	728909	Length:	691	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	113/509 - (22%)
Similarity:	182/509 - (35%)	Gaps:	166/509 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 LSPELMAL-------------NTDPEKAVRVGLKSFSDLLPSKVRNNIVAQAKLKH-----WDKP 234
            |||:|:.|             :.|.|: :.:.|.|..|.|..:..:  ||.|..:.     |..|
  Rat    13 LSPQLLLLLLLCPTGSRAQDEDGDYEE-LMLALPSQEDSLVDEASH--VATATFRRCSKEAWRLP 74

  Fly   235 --------------------HKTATANASRK----------------IVEFESQNPGEASKLPWD 263
                                |:..|..|.|.                :|:..|...|.|.|||..
  Rat    75 GTYVVVLMEETQRLQVEQTAHRLQTWAARRGYVIKVLHVFYDLFPGFLVKMSSDLLGLALKLPHV 139

  Fly   264 KKILKENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGW-LTIVDTTEQGD-------LDQALR 320
            :.|.:::|.|...:..:.|::               ...| .|..|::..|.       ||.:::
  Rat   140 EYIEEDSLVFAQSIPWNLERI---------------IPAWQQTEEDSSPDGSSQVEVYLLDTSIQ 189

  Fly   321 IGEYSRTHETR-NVDDFLSI----SVNVHDEGNVLEVVGMSSPHGTHVSSIASGNHSSRDVDGVA 380
            .|.  |..|.| .:.||.|:    ....|.:.:..:      .||||::.:.||    ||. |||
  Rat   190 SGH--REIEGRVTITDFNSVPEEDGTRFHRQASKCD------SHGTHLAGVVSG----RDA-GVA 241

  Fly   381 PNAKIVSMTI----GDGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIG 441
            ....:.|:.:    |.|.:.....|...:|   |...:...|..:.::.:          :|...
  Rat   242 KGTSLHSLRVLNCQGKGTVSGTLIGLEFIR---KSQLIQPSGPLVVLLPL----------AGGYS 293

  Fly   442 ELMNEVVNKY---GVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLP 503
            .::|....:.   |||.||:|||.....|...   ..|.|.:|.|||           ...:..|
  Rat   294 RILNTACQRLARTGVVLVAAAGNFRDDACLYS---PASAPEVITVGA-----------TNAQDQP 344

  Fly   504 GNVYT-WTSRDPCIDGGQGVTVCAPG----GAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALL- 562
            ..:.| .|:...|:|      :.|||    ||.:......||:|    |||.||.||||.||::
  Rat   345 VTLGTLGTNFGRCVD------LFAPGKDIIGASSDCSTCYMSQS----GTSQAAAHVAGIVAMML 399

  Fly   563 -------ISGLKQQNIEYSPYSI---------KRAISVTATKLGYVDPFAQGHG 600
                   ::.|:|:.|.:|...:         :|.:  |..::..:.|..|..|
  Rat   400 NRDPALTLAELRQRLILFSTKDVINMAWFPEDQRVL--TPNRVATLPPSTQETG 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	110/496 (22%)
		Peptidase_S8	331..600	CDD:278510	72/302 (24%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
Pcsk9	NP_954862.2	Inhibitor_I9	76..148	CDD:283552	12/71 (17%)
		Peptidases_S8_PCSK9_ProteinaseK_like	155..420	CDD:173790	78/329 (24%)
		Peptidase_S8	179..415	CDD:278510	71/285 (25%)
		C-terminal domain. /evidence=ECO:0000250	449..691		1/3 (33%)
		Cell attachment site. /evidence=ECO:0000255	495..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900