DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and Fras1

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	XP_038947596.1	Gene:	Fras1 / 289486	RGDID:	1306516	Length:	4014	Species:	Rattus norvegicus

Alignment Length:	1721	Identity:	320/1721 - (18%)
Similarity:	537/1721 - (31%)	Gaps:	640/1721 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SKKTTNKEQSDKSAESRMATSGIVESFPTGALVPKAETGVLNF-LQKYPEYDGRDVTIAIFDSGV 134
            |..::|:..:||.....:..:|.: :...|::.|      |:| |......||| |...:|....
  Rat  1087 SGHSSNETCTDKVYTPSLHVNGSL-TLGIGSMKP------LDFSLLNIQHQDGR-VEDLLFHIVS 1143

  Fly   135 DPRATGLETLCDGKTVKVIERYDCSGCGDVDMKK-KVTPDENGNIKGLSGNSLKLSPELMALNTD 198
            .|....|....:||.|: :|:.......||:.|| :....:....||..  |||:|.:  ...::
  Rat  1144 TPTNGQLLLSRNGKEVQ-LEKAGHFSWKDVNGKKVRFVHSKEKLRKGYF--SLKISDQ--QFFSE 1203

  Fly   199 PEKAVRVGLKSFSDLLPSKVRNNIVAQAKLKHWDKPHKTATANASRKIVEF-ESQNP-------- 254
            |:   .:.:::||...|..:||.::      |..|..:.|   .:.::::. :..||
  Rat  1204 PQ---LINIQAFSTQAPYVLRNEVL------HISKGERAA---ITTQLLDIRDDDNPQDVVLNVL 1256

  Fly   255 -----GEASKLPWDKKILKENLDFELEMLNSYEKVY---GDIKTSYDCILFPTADGW-----LTI 306
                 |:..:.|  .........|.::.|:....:|   |...|| |.|:|...||.     |..
  Rat  1257 DPPRHGQLLRTP--PAPAASVYQFHVDELSRGLLLYAHDGSDSTS-DIIVFQANDGHSFQNILFR 1318

  Fly   307 VDTTEQGDLDQALRIGEYSRTHETRNVDDFLSISVNVHDEGNVLEVVGMSSPHGTHVSSIASGNH 371
            |....:.  |:|||:               ::.|:....||.:|::
  Rat  1319 VKNVPKN--DRALRL---------------VTNSMVWVPEGGMLKI------------------- 1347

  Fly   372 SSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVMELCRD----GRRIDVINM------ 426
            ::|.:...||.                      |||...:.::..|    |..:.::|:
  Rat  1348 TNRILRAQAPG----------------------VRADDIIYKITHDHPQFGEVVLLMNLPADSPA 1390

  Fly   427 SYGEHANWSNSGRIGELMNEVVNKY-------GVVWVASAGNHGPA------LCTVGTPPDISQP 478
            ...|..:....||    |...|:.:       |:||...:|....:      :.|.....:..|.
  Rat  1391 GPAEEGHHLPDGR----MTTPVSTFSQQDIDDGIVWYRHSGATAQSDSFHFQVSTATNAQEHPQS 1451

  Fly   479 SLIGVGAYVSPQMMEAEYAMREKLP-GNVYTWTSRDPCIDGGQGVTVC-----------APGGAI 531
            .:..:.  :.||.:||     .||. |.....|:|:      .|::|.           :|.|.|
  Rat  1452 HMFNIA--ILPQALEA-----PKLSLGTSLHMTARE------DGLSVIHPQSLSFGKAESPSGKI 1503

  Fly   532 ---ASVP----------------------QFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNI 571
               .:||                      |..:::.|:|.....|.||:...:|...:||
  Rat  1504 IYNITVPLHPNQGVIEHRGRPNSPIRYFTQEEINQGQIMYRPPAAPPHLQEFMAFSFAGL----- 1563

  Fly   572 EYSPYSIKRAISVTATKLGYVDP-FAQGHGLLNVEK---AFEHLTEHRQSKDNMLRFSVRVGNNA 632
               |.|::...:|:..:  :..| .|....||:.::   ||       |.|..:|  .|..|...
  Rat  1564 ---PESVRFYFTVSDGQ--HTSPEMALTIHLLHSDRQPPAF-------QIKAPLL--EVSPGGRT 1614

  Fly   633 DKGIHLRQGVQRNSIDYNVYIEPIF--------------YNDKEA---DPKDKFNFN-VRLNLI- 678
            ..|:.|   |.|   |..|..|.:|              |..|.:   ...|.|.:: |..|::
  Rat  1615 PLGLQL---VVR---DAEVVPEELFFQLQKPPQHGMLMKYTAKSSVTMSAGDTFTYDEVERNVLQ 1673

  Fly   679 ----ASQPW---VQCGAFLDLSYGTRSIAVRVDPT-----GLQPG---------VHSAVIR---- 718
                .|..|   ::......|:..|..:.|.|.|:     .|.||         .|:|:|.
  Rat  1674 YVHDGSPAWEDNMEISVTDGLTVTTSEVKVEVSPSENREPRLAPGSSLSMTVASQHTAIITRSHL 1738

  Fly   719 AYDTDC-------VQKGS--LFEIPVTVVQPHV--LESDQN-------------TPVFE------ 753
            ||..|.       :|..|  |:.:.:....|.:  |..|.|             :.|||
  Rat  1739 AYVDDSSPDSEIWIQLSSLPLYGVLLKTSGPDMEELSGDSNFTMEDINSKNIRYSAVFETEGQSV 1803

  Fly   754 ------PASSKGDNSVEFQPNTIQ-------------RDFILVPE--RATWAELRMRIT---DPN 794
                  ..|...:|.|:.|..||.             .|.|.|.|  ||..:......|   |..
  Rat  1804 TDGFHFSVSDMDNNRVDNQVFTITVTPAENPPHIIAFADLITVDEGGRAPLSLHHFFATEDQDNL 1868

  Fly   795 RGEDIGKFFVHTNQLLPKQSC-RKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQS 858
            :|:.:.|.     ..|||..| ....|......|:.:|...:|.::.  :||
  Rat  1869 QGDAVIKL-----SALPKYGCIENTGTGDRFGPGANSELEASFPIQD--VLE------------- 1913

  Fly   859 HLKYSLRFRGVE-----AHNPNAYVMHAGRG---IHKLEIEALVAEDVQPQLQLK---------- 905
              .|...|:.|.     .|:..::.:..|.|   ||.:.|......|..|::.|:
  Rat  1914 --NYIYYFQSVHESIEPTHDVFSFYVSDGSGRSEIHSINITIERKNDEPPRMTLRPLGVRLSSGV 1976

  Fly   906 ---------------NAEVV-------------LKPTEAKISPLSATRDVIPDGRQ-VYQNLLA- 940
                           |.|::             |:||.:  .||. ...|:..|.. .||::||
  Rat  1977 AISNSSLSLQDLDTPNNELIFVLMKKPDHGYLLLRPTAS--DPLE-NGTVLDQGSSFTYQDILAG 2038

  Fly   941 -----------------FNLNVAKAAD---VSIY------------------------APIFNDL 961
                             |:|......|   :.||                        |.|....
  Rat  2039 LVGYLPGDIYMAVDEFRFSLTDGLHVDTGRMEIYIELPTSNIPHLAINRGLQLSAGSVARITEQH 2103

  Fly   962 LYEAEFESQMWMLFDANKALVATGDAHSHTSFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVAS 1026
            |...:.:|:...|.    .:|.......|...||.||                ||:||
  Rat  2104 LRATDTDSEAGQLV----YIVKEDPGAGHLQMTKADK----------------LEQIS------- 2141

  Fly  1027 FKLTSPLTLDFYENYNQCIVGGRKYVSSPLRLSTRVLYIAPITQERLTKANLPAQCAWLSGNLVF 1091
                                     |..|:|..|:    |.::|.::..::.|.:.   .|:..|
  Rat  2142 -------------------------VRGPIRSFTQ----ADVSQGQIEYSHGPGEA---GGSFAF 2174

  Fly  1092 PQDEV---GRRVAQHPFTYILNPAEKKSH----TN-GSSNGSSAAGSTATAAAVTTANGAKPKA- 1147
            ..|.|   |.::|...|:  :|..|.||.    || |.....::.....||..:.|...:||..
  Rat  2175 KFDVVNGEGNKLADQSFS--INVLEDKSPPVIITNKGLVLDENSVEKITTAQLLATDQDSKPTEL 2237

  Fly  1148 --PATPQAATSVTNPAAGDGISV----------QNDPPVDSSGS--------------------- 1179
              ..|.|.........|..||.:          :|...|.|||:
  Rat  2238 IYRITSQPQLGHLEHVASPGIQISSFTQADLTSRNVQYVHSSGTGKLSDAFSFVLSDGLHEVTQT 2302

  Fly  1180 ------------PASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKH----- 1227
                        |....:|....:...::..:|:. :.|..:.| ||.|...:|.. |:|
  Rat  2303 FSITIHPVDDSLPLVQNRGMRVQEGVRKTITEFEL-KAVDVDTE-AESITFTIVQP-PRHGTIER 2364

  Fly  1228 -----------------LQANLLLIQNIESNQLKSQLPLTFVNAQKTSP----PEAGESADKQKE 1271
                             :..|.:...:..||.||.:  .||..:..|:|    .|.||
  Rat  2365 TARGQRYQLTSSFTMEDIYQNRVSYSHDGSNSLKDR--FTFTVSDGTNPFFIIEEGGE------- 2420

  Fly  1272 DQKKVRSALERIVKLADKVIQETDSEALLSYYGLKNDTRADAAKIKTNMDKQKNTLIEALSKKGI 1336
                             :::.....:.|:....:.:.|    .:|.||:..|....::..:...|
  Rat  2421 -----------------EIMTAAPQQFLVDILPVDDGT----PRIVTNLGLQWLEYMDGKATNLI 2464

  Fly  1337 AVAKLAVLDDCIKDSLAEINELYTEIIKFVDANDSKAIQFALWHAYAHGHYGRMYKYVVKLIEEK 1401
            ...:|..:|...:||     :|..|:..                       |.|:.||...::..
  Rat  2465 TKKELLTVDPDTEDS-----QLTYEVTT-----------------------GPMHGYVENKLQPG 2501

  Fly  1402 R-----TRDHFVELAAINGALGHEHIRTVIN 1427
            |     |::| |.|..|...|..|.|:.:::
  Rat  2502 RVAATFTQEH-VNLGLIRYVLYEEKIQKMMD 2531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	107/571 (19%)
		Peptidase_S8	331..600	CDD:278510	54/329 (16%)
		TPPII	892..1073	CDD:289357	42/264 (16%)
		TPPII_N	1144..1257	CDD:289360	30/180 (17%)
Fras1	XP_038947596.1	VWC	27..86	CDD:214564
		VWC	94..151	CDD:278520
		VWC	158..>198	CDD:327433
		VWC	224..277	CDD:278520
		VWC	284..341	CDD:214564
		VWC	368..415	CDD:327433
		VSP	405..780	CDD:146106
		VSP	728..1059	CDD:146106
		FU	1045..1086	CDD:214589
		Cadherin_3	1101..1197	CDD:406568	26/106 (25%)
		Cadherin_3	1202..1309	CDD:406568	22/121 (18%)
		Cadherin_3	1313..1440	CDD:406568	28/188 (15%)
		Cadherin_3	1448..1576	CDD:406568	29/148 (20%)
		Cadherin_3	1579..1693	CDD:406568	27/128 (21%)
		Cadherin_3	1703..1813	CDD:406568	22/109 (20%)
		Cadherin_3	1822..1940	CDD:406568	27/139 (19%)
		Cadherin_3	1943..2061	CDD:406568	21/120 (18%)
		Cadherin_3	2081..2181	CDD:406568	26/158 (16%)
		Cadherin_3	2188..2295	CDD:406568	23/108 (21%)
		Cadherin_3	2297..2408	CDD:406568	18/115 (16%)
		Cadherin_3	2427..2539	CDD:406568	26/138 (19%)
		Calx-beta	2555..2652	CDD:413355
		Calx-beta	2677..2763	CDD:413355
		caca	<2782..>3049	CDD:273296
		Calx-beta	3041..3135	CDD:413355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900