DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and RSPO1

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_001033722.1 Gene:RSPO1 / 284654 HGNCID:21679 Length:263 Species:Homo sapiens


Alignment Length:202 Identity:46/202 - (22%)
Similarity:69/202 - (34%) Gaps:62/202 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   976 DANKALVATGD----AHSHTSFTKLDKGEYTIRLQVRHEKR---DLLEKISEANLVASFKLTSPL 1033
            |.||.:....:    ..||...||..:|.|.      |:.|   ...|..|.||  .:.:.:||.
Human    90 DMNKCIKCKIEHCEACFSHNFCTKCKEGLYL------HKGRCYPACPEGSSAAN--GTMECSSPA 146

  Fly  1034 TLDFYE-------NYNQCIVGGRKYVSSPLRLSTRVLYIAPI--------TQE--RLTKANLPAQ 1081
            ..:..|       :..|.:.|.|:......|   |||: ||:        |:|  |.|...:|. 
Human   147 QCEMSEWSPWGPCSKKQQLCGFRRGSEERTR---RVLH-APVGDHAACSDTKETRRCTVRRVPC- 206

  Fly  1082 CAWLSGNLVFPQDE------VGRRVAQHPFTYILNPAEKKSHTNGSSN----GSSAAGSTATAAA 1136
                      |:.:      .|||...:     .|.|.|:|...|:.:    |........|...
Human   207 ----------PEGQKRRKGGQGRRENAN-----RNLARKESKEAGAGSRRRKGQQQQQQQGTVGP 256

  Fly  1137 VTTANGA 1143
            :|:|..|
Human   257 LTSAGPA 263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796
Peptidase_S8 331..600 CDD:278510
TPPII 892..1073 CDD:289357 29/120 (24%)
TPPII_N 1144..1257 CDD:289360 46/202 (23%)
RSPO1NP_001033722.1 FU 1 34..85
Furin-like_2 42..144 CDD:318185 15/61 (25%)
FU 2 91..135 11/49 (22%)
PTZ00441 <141..>227 CDD:240420 21/105 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..263 13/72 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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