DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and PCSK9

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_777596.2	Gene:	PCSK9 / 255738	HGNCID:	20001	Length:	692	Species:	Homo sapiens

Alignment Length:	460	Identity:	113/460 - (24%)
Similarity:	166/460 - (36%)	Gaps:	131/460 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 DENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGL-KSFSDLLPSKVRNNIVAQAKLK-HWDKPH 235
            ||:|:.:.|   .|.|..|...|...||....... :...|  |.::....|...|.: |..:..
Human    33 DEDGDYEEL---VLALRSEEDGLAEAPEHGTTATFHRCAKD--PWRLPGTYVVVLKEETHLSQSE 92

  Fly   236 KTA---TANASR-----KIVE-FESQNPG-----------EASKLPW------DKKILKENLDFE 274
            :||   .|.|:|     ||:. |....||           .|.|||.      |..:..:::.:.
Human    93 RTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWN 157

  Fly   275 LEMLNSYEKVYGDIKTSYDCILFPTADGW----LTIVDTTEQGDLDQALRIGEYSRTHETRNVDD 335
            ||.:.         ...|....:...||.    :.::||:.|.|          .|..|.|
Human   158 LERIT---------PPRYRADEYQPPDGGSLVEVYLLDTSIQSD----------HREIEGR---- 199

  Fly   336 FLSISVNVHDEGNVLEVVG--------MSSPHGTHVSSIASGNHSSRDVDGVAPNAKIVSMTI-- 390
                 |.|.|..||.|..|        ....||||::.:.||    ||. |||..|.:.|:.:
Human   200 -----VMVTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSG----RDA-GVAKGASMRSLRVLN 254

  Fly   391 --GDGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKY-- 451
              |.|.:.....|...:|....|..:   |..:.::.:          :|....::|....:.
Human   255 CQGKGTVSGTLIGLEFIRKSQLVQPV---GPLVVLLPL----------AGGYSRVLNAACQRLAR 306

  Fly   452 -GVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYT-WTSRDP 514
             |||.|.:|||.....|...   ..|.|.:|.|||           ...:..|..:.| .|:...
Human   307 AGVVLVTAAGNFRDDACLYS---PASAPEVITVGA-----------TNAQDQPVTLGTLGTNFGR 357

  Fly   515 CIDGGQGVTVCAPGGAI--ASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISG--------LKQQ 569
            |:|      :.|||..|  ||....|...||  :|||.||.||||..|:::|.        |:|:
Human   358 CVD------LFAPGEDIIGASSDCSTCFVSQ--SGTSQAAAHVAGIAAMMLSAEPELTLAELRQR 414

  Fly   570 NIEYS 574
            .|.:|
Human   415 LIHFS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	113/460 (25%)
		Peptidase_S8	331..600	CDD:278510	72/270 (27%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
PCSK9	NP_777596.2	Inhibitor_I9	77..149	CDD:283552	18/71 (25%)
		Peptidases_S8_PCSK9_ProteinaseK_like	156..421	CDD:173790	83/332 (25%)
		Peptidase_S8	180..422	CDD:278510	78/299 (26%)
		C-terminal domain	450..692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900