DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TppII and tpp2

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_594951.1 Gene:tpp2 / 2543179 PomBaseID:SPAP8A3.12c Length:1274 Species:Schizosaccharomyces pombe


Alignment Length:1381 Identity:392/1381 - (28%)
Similarity:652/1381 - (47%) Gaps:236/1381 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 NSSKKTTNKEQSDKSAESRMATSGIVES------FPTGALVPKAETGVLNFLQKYPEYDGRDVTI 127
            :|:||:.....|......|..|:.::.|      :|...:|||.||....||:|:||||||.||:
pombe    33 SSAKKSGILRNSYNQRTERYFTNIMIPSDYSNKFYPVDGVVPKHETQAYEFLKKFPEYDGRGVTV 97

  Fly   128 AIFDSGVDPRATGLETLCDG--KTVKVIERYDCSGCGDVDMKKKVTPDENGN---IKGLSGNSLK 187
            .|.|:||||.|.||.....|  |...::   ||:|.||||...:|...::.:   |.|.||.:||
pombe    98 GILDTGVDPGAPGLSVTTTGLPKFKNIV---DCTGAGDVDTSVEVAAADSNDYLTITGRSGRTLK 159

  Fly   188 LSPELMALNTDPEKAVRVGLKSFSDLLPSKVRNNIVAQAKLKHWDKPHKTATANASRKIVEFESQ 252
            ||.|.    .:|.|..:||.|...:..|..:|..: .:.:.:..:|.::....:|:.:..:|:.:
pombe   160 LSKEW----KNPSKKWKVGCKLAYEFFPKDLRKRL-QKLETEDMNKSNRKLLQDATDEYAKFKDK 219

  Fly   253 NPGEASKLPWDKKIL--KENLDFELEMLNSYEKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDL 315
            .|    :.|.||..|  ::.|:..:|.|....:.:.:....||.::|...:.|..::|:.:.||:
pombe   220 FP----EAPLDKDNLQTQKELEARIECLKQLAEKFDNPGPLYDVVVFHDGEHWRVVIDSDQTGDI 280

  Fly   316 DQALRIGEYSRTHE--TRNVDDFLSISVNVHDEGNVLEVVGMSSPHGTHVSSIASGNH-SSRDVD 377
            .....:.:::...|  |....|.||..|:|:|.||:..:|.:|..|||||:.|...|| .:.:::
pombe   281 YLHKPLADFNVAQEWSTFGSLDLLSYGVHVYDNGNITSIVAVSGTHGTHVAGIIGANHPETPELN 345

  Fly   378 GVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGE 442
            |.||..::||:.||||||.|:||..|..||.:::::     ..:|:||:|:||.|...|.||:.|
pombe   346 GAAPGCQLVSLMIGDGRLDSLETSHAFSRACSEIIK-----NEVDIINISFGEDAGIPNKGRVIE 405

  Fly   443 LM-NEVVNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNV 506
            |: :|:..|..||.|:||||:|||..|||.|...:. .:|.|||||:..||:|:|.:...:....
pombe   406 LLRDELAGKRNVVIVSSAGNNGPAYTTVGAPGGTTF-DVISVGAYVTSGMMQAQYNLLSTVHDTP 469

  Fly   507 YTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNI 571
            |||.||.|.:||..||::.||||||.|||.:::..|||||||||::|...|.::|::|.||.|..
pombe   470 YTWCSRGPTLDGDTGVSIYAPGGAITSVPPYSLQNSQLMNGTSMSSPSACGGISLILSALKAQKK 534

  Fly   572 EYSPYSIKRAISVTATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRFSVRVGN--NADK 634
            .|:..:||:|:..|:..|.  |.|  ..|:|.|:.|:|:|.:..........|::. ||  |:.:
pombe   535 PYTAAAIKKAVMYTSKDLR--DDF--NTGMLQVDNAYEYLAQSDFQYTGARSFTIN-GNIGNSKR 594

  Fly   635 GIHLRQGVQRNSIDYNVY-IEPIFYNDKEADPKDKFNFNVRLNLIASQPWVQCGAFLDLSYGTRS 698
            |::||...:..|...::: :.|.|   ::.:..:|.:|.|:|:|..:|||:|...::.::...|.
pombe   595 GVYLRNPTEVCSPSRHMFNVAPKF---EDGEEYEKSHFEVQLSLATTQPWIQAPEYVMMAGTGRG 656

  Fly   699 IAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEIPVTVVQPHVLESDQNTPVFEPASSKGDNSV 763
            |.||||||.|.||.|...:.|||.....:..:|||||||::|   .|..||     ..|..|  |
pombe   657 IPVRVDPTALAPGHHFGKVLAYDASNESRRCVFEIPVTVMKP---SSISNT-----CFSLRD--V 711

  Fly   764 EFQPNTIQRDFILVPERATWAELRMRITDPNRGEDIGKFFVHTNQLLPKQSCRKLETMKIVSVGS 828
            .|:|..|:|.|::.|:.||:.|:|::.|  :..|.....::..||.:|:....:..|..|:.|..
pombe   712 SFEPTLIKRHFLVPPKGATYVEIRVKAT--SELESTNMLWISVNQTIPQTKLNEASTELIMPVTQ 774

  Fly   829 ENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGVEAHNPNAYVMHAGRGIHKLEIEAL 893
            ...:.....:.....||||:|::||:.....|...:.|.|::..|.....:.:.:|:.:::..::
pombe   775 NEVTTKLVSIDDSYTLELCMAQWWSSLEPMVLDIDVNFHGIKVVNGKEINLISSQGLKRVDCASI 839

  Fly   894 VAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVIPDGRQVYQNLLAFNLNVAKAADVSI-YAPI 957
            ..|:.:|.:.||:.....|||...|.|| ..||::|||:|:::.:..:::.:::..::.. :|..
pombe   840 RRENFKPDITLKDYVDSFKPTNTVIKPL-GDRDIMPDGQQLFELMATYSVEISEKTELKADFAVP 903

  Fly   958 FNDLLYEAEFESQMWMLFDANKALVATGDAH--SHTSFTKLDKGEYTIRLQVRHEKRDLLEKISE 1020
            .|  :|:..|....:|:||:.|..|..||.:  |||    |:||||..:.|:.......||:...
pombe   904 HN--MYDNGFNGLFFMVFDSQKQRVHYGDMYTSSHT----LEKGEYLYKFQLLSVDPSTLERFRN 962

  Fly  1021 ANLVASFKLTSPLTL-------DF-----YENYN-------QCIVG----GRKYVSSPLRLSTRV 1062
            ..|..:.||..|:||       ||     ||..|       ..:||    |.:|.|.        
pombe   963 VTLRLTKKLKKPITLPLYADHIDFCDNKTYERENIDAGVVESFVVGTNIEGEQYASE-------- 1019

  Fly  1063 LYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQHPFTYILNPAEKKSHTNGSSNGSSA 1127
                       .|.|     :.|:|.|.|...|.|    ..|.|.:|.|.               
pombe  1020 -----------LKEN-----SLLTGELKFGDCEKG----TVPVTLVLPPK--------------- 1049

  Fly  1128 AGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQNDPPVDSSGSPASPKKGKANADD 1192
                                                  ||.:.|           .|.|:     
pombe  1050 --------------------------------------ISTKED-----------TKLGE----- 1060

  Fly  1193 YAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANLLLIQNIESNQLKSQLPLTFVNAQKT 1257
                    :|:.||:.::::..|:.:.....|.|:||::.       .|.|:.||          
pombe  1061 --------KCANIVQLQVDLLSKLADQEKEKHLKYLQSSY-------KNSLEVQL---------- 1100

  Fly  1258 SPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSEALLSYYGLK---NDTRADAAKIKTN 1319
                  ...|..||..:::.:        ||.::...|:|||..||..:   .||......::..
pombe  1101 ------AKLDIVKETNERLST--------ADSILSLIDTEALSRYYSCQQKVEDTIPRDVVLEKK 1151

  Fly  1320 MDKQKNTLIEALSKKGIAVAKLAVLDDCIKDSLAEINELYTEIIKFVDANDSKAIQFALWHAYAH 1384
            |..|::..|.||..|....:.....|   ||:..:..:|   ::.:::.:|.:..|....:..:.
pombe  1152 MALQRDAFIRALVVKCETFSTQGHKD---KDNYFQNYQL---LLNWLENSDPRVWQIKKDYYKSQ 1210

  Fly  1385 GHYGRMYKYVVKLIEE 1400
            ..||...|.:::|::|
pombe  1211 NQYGLALKALLELLKE 1226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 184/498 (37%)
Peptidase_S8 331..600 CDD:278510 116/270 (43%)
TPPII 892..1073 CDD:289357 54/206 (26%)
TPPII_N 1144..1257 CDD:289360 17/112 (15%)
tpp2NP_594951.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 71..552 CDD:173796 184/498 (37%)
Peptidase_S8 271..552 CDD:278510 118/286 (41%)
TPPII 837..1008 CDD:289357 49/177 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 287 1.000 Domainoid score I287
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2471
Inparanoid 1 1.050 531 1.000 Inparanoid score I214
OMA 1 1.010 - - QHG58290
OrthoFinder 1 1.000 - - FOG0005779
OrthoInspector 1 1.000 - - oto101866
orthoMCL 1 0.900 - - OOG6_104037
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1540
SonicParanoid 1 1.000 - - X4170
TreeFam 1 0.960 - -
1312.760

Return to query results.
Submit another query.