DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and Pcsk1

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_058787.1	Gene:	Pcsk1 / 25204	RGDID:	3272	Length:	752	Species:	Rattus norvegicus

Alignment Length:	876	Identity:	166/876 - (18%)
Similarity:	286/876 - (32%)	Gaps:	290/876 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 NSLKLSPELM-----ALNTDPEKAVRVGLKSFSDLLP--SKVRNNIVAQAKLKHWDKP------- 234
            ||:|...:.:     .::..||.|..:..:...|||.  ..:.|:.:    .||.:.|
  Rat    23 NSVKAKRQFVNEWAAEIHGGPEAASAIAEELGYDLLGQIGSLENHYL----FKHKNHPRRSRRSA 83

  Fly   235 -HKTATANASRKIVEFESQNPGEASK--LPWDKKILKENLDFELEMLNSYEKVYGDIKTSYDCIL 296
             |.|...:...:::..|.|...|..|  :|.|..:   || |...|.|....:.....|:    .
  Rat    84 LHITKRLSDDDRVIWAEQQYEKERRKRSVPRDSAL---NL-FNDPMWNQQWYLQDTRMTA----S 140

  Fly   297 FPTADGWLTIVDTTEQG---------DLDQALRIGEYSRTHETRNVDDFLSISVNVHDEG----- 347
            .|..|  |.::...::|         .||..|   |::.|....|.|...|...|.:|..
  Rat   141 LPKLD--LHVIPVWQKGITGKGVVITVLDDGL---EWNHTDIYANYDPEASYDFNDNDHDPFPRY 200

  Fly   348 ---NVLEVVGMSSPHGTHVS---SIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVR 406
               |       .:.|||..:   ::.:.||...  .|||.|:|:..:.:.||
  Rat   201 DPTN-------ENKHGTRCAGEIAMQANNHKCG--VGVAYNSKVGGIRMLDG------------- 243

  Fly   407 AMTKVMELCRDG---RRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCT 468
            .:|..:|....|   ..:|:.:.|:|.    ::.|:                            |
  Rat   244 IVTDAIEASSIGFNPGHVDIYSASWGP----NDDGK----------------------------T 276

  Fly   469 VGTPPDISQPSLIGVGAYVSPQMMEAEYAMRE--KLPGNVYTWTSRDPCIDGGQGVTVCAPGGAI 531
            |..|..::|.:.              ||.:::  :..|:::.|.|.    :||:....|...|..
  Rat   277 VEGPGRLAQKAF--------------EYGVKQGRQGKGSIFVWASG----NGGRQGDNCDCDGYT 323

  Fly   532 ASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFA 596
            .|:  :|:|                      ||...||.:  ||:..::..|..||.....|
  Rat   324 DSI--YTIS----------------------ISSASQQGL--SPWYAEKCSSTLATSYSSGD--- 359

  Fly   597 QGHGLLNVEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYNVYI-----EPI 656
                          .|:.|.:..::................|..|:...:::.|..:     :.:
  Rat   360 --------------YTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHL 410

  Fly   657 FYNDKEADPKDKFNFNVRLNLIASQP-WVQCGAFLDLS----YG---TRSIAVRVDPTGLQPGVH 713
            .....|.||            :|:.| |.:.||.|.::    :|   .:::....||
  Rat   411 VVWTSEYDP------------LANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADP-------- 455

  Fly   714 SAVIRAY-----DTDCVQKGSLF-------------EIPVTVV--QPHVLESDQNTPVFEPA--- 755
                |.:     ..:|:.|.:.|             |||....  |.:.:.|.::.. ||..
  Rat   456 ----RTWRNVPEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINSLEHVQ-FEATIEY 515

  Fly   756 SSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGEDIGKFFVHTNQLLPKQSCRKLET 820
            |.:||..|.. .:......:|:.||.       |.|.||..::.....|||....|..:.    |
  Rat   516 SRRGDLHVTL-TSAAGTSTVLLAERE-------RDTSPNGFKNWDFMSVHTWGENPVGTW----T 568

  Fly   821 MKIVSVGS--ENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGVEAHNPNAY-----V 878
            :|:..:..  :||         |||:...:..:.::....|:|           .|..|     |
  Rat   569 LKVTDMSGRMQNE---------GRIVNWKLILHGTSSQPEHMK-----------QPRVYTSYNTV 613

  Fly   879 MHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVIPDG--RQVYQNLL-- 939
            .:..||:.|:   ..|.|:...|..|...  :|.|..:..|.:...||....|  .:....||
  Rat   614 QNDRRGVEKM---VNVVEEKPTQNSLNGN--LLVPKNSSSSSVEDRRDEQVQGAPSKAMLRLLQS 673

  Fly   940 AFNLNV-----AKAADVSIYAPIFNDLLYEA 965
            ||:.|.     :|.....:..|.  :.||||
  Rat   674 AFSKNTPSKQSSKIPSAKLSVPY--EGLYEA 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	86/446 (19%)
		Peptidase_S8	331..600	CDD:278510	51/284 (18%)
		TPPII	892..1073	CDD:289357	21/83 (25%)
		TPPII_N	1144..1257	CDD:289360
Pcsk1	NP_058787.1	S8_pro-domain	34..110	CDD:406785	15/79 (19%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	69/417 (17%)
		P_proprotein	504..591	CDD:396185	24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..662		7/32 (22%)
		Proho_convert	712..750	CDD:403415
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900