DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and Pcsk2

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_036878.1	Gene:	Pcsk2 / 25121	RGDID:	3273	Length:	637	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	65/291 - (22%)
Similarity:	105/291 - (36%)	Gaps:	95/291 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 HGT----HVSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVME---LCR 416
            |||    .||:.||.|...   .|||.|:|:..:.:.|...            ||.::|   :..
  Rat   207 HGTRCAGEVSAAASNNICG---VGVAYNSKVAGIRMLDQPF------------MTDIIEASSISH 256

  Fly   417 DGRRIDVINMSYGEHANWSNSGRIGEL----MNEVVNK----YGVVWVASAGNHGPALCTVGTPP 473
            ..:.||:.:.|:|...|........||    |.:.|||    .|.::|.::|:.       |:..
  Rat   257 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDG-------GSYD 314

  Fly   474 DISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWT-SRDPCIDGGQGVTV---CAPGGAIASV 534
            |.:      ...|.|..                  || |.:..|:.|:....   |:  ..:||.
  Rat   315 DCN------CDGYASSM------------------WTISINSAINDGRTALYDESCS--STLAST 353

  Fly   535 --------PQFTMSKSQLM-------NGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISV 584
                    |:..::.:.|.       :|||.|||..||..||.:    :.|::.:...::....:
  Rat   354 FSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAL----EANVDLTWRDMQHLTVL 414

  Fly   585 TATKLGYVDPFAQ----GHGLLNVEKAFEHL 611
            |:.:....|...|    |.||     .|.||
  Rat   415 TSKRNQLHDEVHQWRRNGVGL-----EFNHL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	57/263 (22%)
		Peptidase_S8	331..600	CDD:278510	60/278 (22%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
Pcsk2	NP_036878.1	S8_pro-domain	32..108	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	121..417	CDD:173789	57/261 (22%)
		Peptidase_S8	157..434	CDD:278510	60/278 (22%)
		P_proprotein	503..590	CDD:279782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900