DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and Fras1

DIOPT Version :10

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_780682.3 Gene:Fras1 / 231470 MGIID:2385368 Length:4010 Species:Mus musculus


Alignment Length:1513 Identity:289/1513 - (19%)
Similarity:479/1513 - (31%) Gaps:479/1513 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 ISLSRPYMAYMG--TERSVVM--ITAPATKEFAESSERSNSSKK---TTNKEQSDKSAESRMATS 91
            :.||.|..|.:|  |:..||:  .....|.||.:.:.|.|.|..   ...|.|.|.|:    ..|
Mouse  2645 VGLSMPAYALLGEFTQAKVVINDTEDEPTLEFDKKTYRVNESAGFLFAPIKRQGDSSS----TVS 2705

  Fly    92 GIVESFPTGALVPKAETG-VLNFLQKYPEYDGRDVTI---AIFDSGVDPRATGLETLCDGKTVKV 152
            .:..:      |||:..| .|..|:...::..|..:.   .||..||      ..:.||   |.|
Mouse  2706 AVCYT------VPKSAMGSSLYALESGSDFKSRGRSAESRVIFGPGV------TVSTCD---VMV 2755

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMA--LNTDPEKAVRVGLKSFSDLLP 215
            |:        |.:.:::   :|.......:.|:.::..:.:|  |.:.|..|..|.|.:.:..:.
Mouse  2756 ID--------DSEYEEE---EEFEIALADASNNARIGRQAVAKVLISGPNDASTVSLGNTAFTIS 2809

  Fly   216 SK--------VRNNIVAQAKLKHW--DKPHKTATAN-------ASRKIVEFESQNPG-------- 255
            ..        :|:..........|  .:|...|:|.       :||| |||   .||        
Mouse  2810 EDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRK-VEF---GPGITEQYCTL 2870

  Fly   256 ---EASKLPWDKKILKENLDFELEMLNSYE---------------KVYGDIKT---SYDCILFPT 299
               :.::.|     :.|.|:..:..|:|.:               ..:.|:.:   |.|.:|...
Mouse  2871 TILDDTQYP-----VIEGLETFVVFLSSAQGAELTKPSQAVIAINDTFQDVPSMQFSKDLLLVKE 2930

  Fly   300 ADGWLTIVDTTEQGDLDQALRIGEYSRTH---------ETRNVDD----FL------SISVNVHD 345
            .:|.|.| .....|||.....:..|::.|         |.||.|.    ||      :.:|.:||
Mouse  2931 KEGVLHI-PIIRSGDLSYESSVRCYTQGHSAQVMEDFEERRNADSSRITFLKGQKTKNCTVYIHD 2994

  Fly   346 EGNVLEV-----VGMSSPHGTHVSSIASGNHS------SRDVDG---------------VAPNAK 384
            : ::.|.     |.:..|.|.|.|....|.:|      |.|.|.               ..|.| 
Mouse  2995 D-SMFEPEEQFRVYLGHPLGNHWSGARIGKNSVATVTISNDEDAPTIEFEEAAYQVREPAGPEA- 3057

  Fly   385 IVSMTIGDGRLGSMETGTALVRAMTKVMELCRDGRR---ID------VINMSYG----------- 429
            |..::|...|.|. :..|:.:|..|      |||..   :|      |:..|.|           
Mouse  3058 IAVLSIKVIRRGD-QNRTSKIRCST------RDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEIL 3115

  Fly   430 --EHANWSNSGRI----GELMNEVVNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVS 488
              |...|..|..:    .:|:..|:.......|............:..||.:     :.:..|..
Mouse  3116 SNEDREWHESFSLVLGPDDLVEAVLGDVTTATVTILDQEAAGSLILPAPPIV-----VTLADYDH 3175

  Fly   489 PQMMEAEYAMREKLPG-NVYTWTSRDP-----------CIDGGQGVT-------VCAP---GGA- 530
            .:.:..|...:...|| .:...|..||           |.:.|...|       |.||   .|| 
Mouse  3176 VEELAKEGVKKAPSPGYPLVCVTPCDPRYPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGAR 3240

  Fly   531 -----IASVPQFTMSKSQLMN----------------------------------GTSMA---AP 553
                 |.....||....::::                                  ||..|   .|
Mouse  3241 SPFETITDNTPFTSVNHKVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNVVTIGTDSAICHTP 3305

  Fly   554 HVAGA-----VALLISGLKQQNIEYSPYSIKRAISVTATKLGYVD---------PFAQGHGLLNV 604
            .|||.     ....|:.||..::::..:..:..|||   ::.:.|         |....|.||: 
Mouse  3306 VVAGTARGFQAQSFIATLKYLDVKHKEHPNRIHISV---QIPHQDGMLPLISTMPLHNLHFLLS- 3366

  Fly   605 EKAFEHLTEHRQSKDNM-----LRFSVRVGNNADKGIH---LRQGVQRNSIDYNVYIEPIFYNDK 661
                |.:..|:....|:     ||.....|...|.|.|   |..|          |..|..::..
Mouse  3367 ----ESIYRHQHVCSNLVTAQDLRGLAEAGFLNDAGFHSTALGPG----------YDRPFQFDSS 3417

  Fly   662 EADPKDKFNFNVRLNLIASQPWV------------QCGAFLDLSYGTRS-----IAVRVD----- 704
            ..:|| .......||| .|..|.            .||..:...:..|.     :.|.|.     
Mouse  3418 VREPK-TIQLYRHLNL-KSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVSY 3480

  Fly   705 -----PTGLQPGVHSAVIR---AYDT----DCVQKGSLFEIPVTVVQPHVLESDQNTPVFEP-AS 756
                 |.|.....|...:.   .|||    ..:|..|:....:.:::.::.|..:....|:. |.
Mouse  3481 IYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAK 3545

  Fly   757 SKGDNSVEFQPNTIQRDFILVPE---------RATWA--------ELRMRITDPNRGEDIGKFFV 804
            .:|...:|.......:.|||.|:         :..|:        :|....:..||.:..|::.:
Mouse  3546 FRGQFVIEHHTLPDVKSFILTPDHLGGIQFDLQLLWSAQTFDSPHQLWRATSSYNRKDYSGEYTI 3610

  Fly   805 HTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGV 869
            :   |:|   |....|..                             |.:.|:..|       ..
Mouse  3611 Y---LIP---CTVQPTQP-----------------------------WVDPGEKAL-------AC 3633

  Fly   870 EAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVV--LKPTEAKISPL------SATRD 926
            .||.|..:::..  ...:......|...:..:.||.|.|.|  :.|..:.:|..      :.::.
Mouse  3634 TAHAPERFLIPI--AFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKG 3696

  Fly   927 VIPDGRQVY---QNL-LAFNLNVAK---AADVSIYAPIFN--DLLYEAEFESQMWMLFDANKALV 982
            .|..||.::   ||| .|:.|.:.|   ......|.|.|:  ..:|.   |...:.....||   
Mouse  3697 QILYGRVLWNPEQNLHSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYN---EGPQYGCIQPNK--- 3755

  Fly   983 ATGDAHSHTSFTKLDKGEYTIRLQVRHE---KRDLLEKISEANLVASFKLTSPLTLDFYENYNQC 1044
                 |....|..||:.:..:..:..|:   :.....::.:..:|:|.......||.....|.  
Mouse  3756 -----HLKHRFLLLDRSQPEVTDKYFHDVPFEAHFASELPDFQVVSSMPGVDGFTLKVDALYK-- 3813

  Fly  1045 IVGGRKYVSSPLRLSTRVLYI-------APITQERLT------KANLPAQCAWLS--GNLVFPQD 1094
            :..|.::.       .:|:||       .|..|..||      :.:|.....|||  .:|::  |
Mouse  3814 VEAGHQWY-------LQVIYIIGPDSTSRPRVQRSLTVSLRRHQRDLVDPSGWLSLDDSLIY--D 3869

  Fly  1095 EVGRRVAQHPFTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTN 1159
            ..|.:|.        |....||..........||..:.|.|::.:|..|..........|..||.
Mouse  3870 NEGDQVK--------NGTNMKSLNLEMQEPVIAASLSQTGASIGSALAAIMLLLLLFLVACFVTR 3926

  Fly  1160 PAAGDGISVQNDPPVDS-SGSPASPK--KGKANAD--------DYA-----------ESFRDFQC 1202
            ....   ..:..||.|: ...|.:.|  ..|.|||        .|.           |.:..|:.
Mouse  3927 KCQK---QKKKQPPEDTLEEYPLNTKVDVAKRNADKVEKNANRQYCTVRNVNILSDNEGYYTFKG 3988

  Fly  1203 SQIVKCELEMAEKIYNDV 1220
            :::.|..||:  :::|::
Mouse  3989 AKVKKLNLEV--RVHNNL 4004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 130/680 (19%)
TPPII 892..1077 CDD:463636 42/217 (19%)
TPPII_N 1144..1257 CDD:403697 19/99 (19%)
Fras1NP_780682.3 VWC 27..86 CDD:214564
VWC 94..151 CDD:278520
VWC 158..215 CDD:278520
VWC 220..277 CDD:278520
VWC 284..341 CDD:450195
VWC 368..415 CDD:450195
VSP 405..780 CDD:146106
FU 1 408..459
FU 2 461..504
FU 3 506..552
FU 4 554..598
FU 5 601..646
FU 6 648..704
FU 7 707..752
FU 8 754..799
VSP 762..1059 CDD:146106
FU 9 802..851
FU 10 853..899
FU 11 902..947
FU 12 951..996
FU 13 998..1041
FU 14 1045..1088
FU 1045..1086 CDD:214589
Cadherin_3 1101..1197 CDD:465048
CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1101..1196
Cadherin_3 1202..1309 CDD:465048
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1216..1307
Cadherin_3 1313..1440 CDD:465048
CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1328..1440
Cadherin_3 1448..1576 CDD:465048
CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1465..1561
Cadherin_3 1579..1693 CDD:465048
CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1597..1691
Cadherin_3 1703..1813 CDD:465048
CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1712..1812
Cadherin_3 1818..1940 CDD:465048
CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1834..1938
Cadherin_3 1943..2061 CDD:465048
CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1959..2059
Cadherin_3 2071..2181 CDD:465048
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2080..2179
Cadherin_3 2188..2295 CDD:465048
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2201..2293
Cadherin_3 2297..2408 CDD:465048
CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2313..2406
Cadherin_3 2427..2539 CDD:465048
CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2441..2538
caca <2555..>2810 CDD:273296 44/194 (23%)
Calx-beta 2555..2648 CDD:413355 0/2 (0%)
caca <2778..>3045 CDD:273296 56/277 (20%)
Calx-beta 3037..3131 CDD:413355 19/101 (19%)
Blue background indicates that the domain is not in the aligned region.

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