DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and Fras1

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_780682.3	Gene:	Fras1 / 231470	MGIID:	2385368	Length:	4010	Species:	Mus musculus

Alignment Length:	1513	Identity:	289/1513 - (19%)
Similarity:	479/1513 - (31%)	Gaps:	479/1513 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ISLSRPYMAYMG--TERSVVM--ITAPATKEFAESSERSNSSKK---TTNKEQSDKSAESRMATS 91
            :.||.|..|.:|  |:..||:  .....|.||.:.:.|.|.|..   ...|.|.|.|:    ..|
Mouse  2645 VGLSMPAYALLGEFTQAKVVINDTEDEPTLEFDKKTYRVNESAGFLFAPIKRQGDSSS----TVS 2705

  Fly    92 GIVESFPTGALVPKAETG-VLNFLQKYPEYDGRDVTI---AIFDSGVDPRATGLETLCDGKTVKV 152
            .:..:      |||:..| .|..|:...::..|..:.   .||..||      ..:.||   |.|
Mouse  2706 AVCYT------VPKSAMGSSLYALESGSDFKSRGRSAESRVIFGPGV------TVSTCD---VMV 2755

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMA--LNTDPEKAVRVGLKSFSDLLP 215
            |:        |.:.:::   :|.......:.|:.::..:.:|  |.:.|..|..|.|.:.:..:.
Mouse  2756 ID--------DSEYEEE---EEFEIALADASNNARIGRQAVAKVLISGPNDASTVSLGNTAFTIS 2809

  Fly   216 SK--------VRNNIVAQAKLKHW--DKPHKTATAN-------ASRKIVEFESQNPG-------- 255
            ..        :|:..........|  .:|...|:|.       :||| |||   .||
Mouse  2810 EDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRK-VEF---GPGITEQYCTL 2870

  Fly   256 ---EASKLPWDKKILKENLDFELEMLNSYE---------------KVYGDIKT---SYDCILFPT 299
               :.::.|     :.|.|:..:..|:|.:               ..:.|:.:   |.|.:|...
Mouse  2871 TILDDTQYP-----VIEGLETFVVFLSSAQGAELTKPSQAVIAINDTFQDVPSMQFSKDLLLVKE 2930

  Fly   300 ADGWLTIVDTTEQGDLDQALRIGEYSRTH---------ETRNVDD----FL------SISVNVHD 345
            .:|.|.| .....|||.....:..|::.|         |.||.|.    ||      :.:|.:||
Mouse  2931 KEGVLHI-PIIRSGDLSYESSVRCYTQGHSAQVMEDFEERRNADSSRITFLKGQKTKNCTVYIHD 2994

  Fly   346 EGNVLEV-----VGMSSPHGTHVSSIASGNHS------SRDVDG---------------VAPNAK 384
            : ::.|.     |.:..|.|.|.|....|.:|      |.|.|.               ..|.|
Mouse  2995 D-SMFEPEEQFRVYLGHPLGNHWSGARIGKNSVATVTISNDEDAPTIEFEEAAYQVREPAGPEA- 3057

  Fly   385 IVSMTIGDGRLGSMETGTALVRAMTKVMELCRDGRR---ID------VINMSYG----------- 429
            |..::|...|.|. :..|:.:|..|      |||..   :|      |:..|.|
Mouse  3058 IAVLSIKVIRRGD-QNRTSKIRCST------RDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEIL 3115

  Fly   430 --EHANWSNSGRI----GELMNEVVNKYGVVWVASAGNHGPALCTVGTPPDISQPSLIGVGAYVS 488
              |...|..|..:    .:|:..|:.......|............:..||.:     :.:..|..
Mouse  3116 SNEDREWHESFSLVLGPDDLVEAVLGDVTTATVTILDQEAAGSLILPAPPIV-----VTLADYDH 3175

  Fly   489 PQMMEAEYAMREKLPG-NVYTWTSRDP-----------CIDGGQGVT-------VCAP---GGA- 530
            .:.:..|...:...|| .:...|..||           |.:.|...|       |.||   .||
Mouse  3176 VEELAKEGVKKAPSPGYPLVCVTPCDPRYPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGAR 3240

  Fly   531 -----IASVPQFTMSKSQLMN----------------------------------GTSMA---AP 553
                 |.....||....::::                                  ||..|   .|
Mouse  3241 SPFETITDNTPFTSVNHKVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNVVTIGTDSAICHTP 3305

  Fly   554 HVAGA-----VALLISGLKQQNIEYSPYSIKRAISVTATKLGYVD---------PFAQGHGLLNV 604
            .|||.     ....|:.||..::::..:..:..|||   ::.:.|         |....|.||:
Mouse  3306 VVAGTARGFQAQSFIATLKYLDVKHKEHPNRIHISV---QIPHQDGMLPLISTMPLHNLHFLLS- 3366

  Fly   605 EKAFEHLTEHRQSKDNM-----LRFSVRVGNNADKGIH---LRQGVQRNSIDYNVYIEPIFYNDK 661
                |.:..|:....|:     ||.....|...|.|.|   |..|          |..|..::..
Mouse  3367 ----ESIYRHQHVCSNLVTAQDLRGLAEAGFLNDAGFHSTALGPG----------YDRPFQFDSS 3417

  Fly   662 EADPKDKFNFNVRLNLIASQPWV------------QCGAFLDLSYGTRS-----IAVRVD----- 704
            ..:|| .......||| .|..|.            .||..:...:..|.     :.|.|.
Mouse  3418 VREPK-TIQLYRHLNL-KSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVSY 3480

  Fly   705 -----PTGLQPGVHSAVIR---AYDT----DCVQKGSLFEIPVTVVQPHVLESDQNTPVFEP-AS 756
                 |.|.....|...:.   .|||    ..:|..|:....:.:::.::.|..:....|:. |.
Mouse  3481 IYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAK 3545

  Fly   757 SKGDNSVEFQPNTIQRDFILVPE---------RATWA--------ELRMRITDPNRGEDIGKFFV 804
            .:|...:|.......:.|||.|:         :..|:        :|....:..||.:..|::.:
Mouse  3546 FRGQFVIEHHTLPDVKSFILTPDHLGGIQFDLQLLWSAQTFDSPHQLWRATSSYNRKDYSGEYTI 3610

  Fly   805 HTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGV 869
            :   |:|   |....|..                             |.:.|:..|       ..
Mouse  3611 Y---LIP---CTVQPTQP-----------------------------WVDPGEKAL-------AC 3633

  Fly   870 EAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVV--LKPTEAKISPL------SATRD 926
            .||.|..:::..  ...:......|...:..:.||.|.|.|  :.|..:.:|..      :.::.
Mouse  3634 TAHAPERFLIPI--AFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKG 3696

  Fly   927 VIPDGRQVY---QNL-LAFNLNVAK---AADVSIYAPIFN--DLLYEAEFESQMWMLFDANKALV 982
            .|..||.::   ||| .|:.|.:.|   ......|.|.|:  ..:|.   |...:.....||
Mouse  3697 QILYGRVLWNPEQNLHSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYN---EGPQYGCIQPNK--- 3755

  Fly   983 ATGDAHSHTSFTKLDKGEYTIRLQVRHE---KRDLLEKISEANLVASFKLTSPLTLDFYENYNQC 1044
                 |....|..||:.:..:..:..|:   :.....::.:..:|:|.......||.....|.
Mouse  3756 -----HLKHRFLLLDRSQPEVTDKYFHDVPFEAHFASELPDFQVVSSMPGVDGFTLKVDALYK-- 3813

  Fly  1045 IVGGRKYVSSPLRLSTRVLYI-------APITQERLT------KANLPAQCAWLS--GNLVFPQD 1094
            :..|.::.       .:|:||       .|..|..||      :.:|.....|||  .:|::  |
Mouse  3814 VEAGHQWY-------LQVIYIIGPDSTSRPRVQRSLTVSLRRHQRDLVDPSGWLSLDDSLIY--D 3869

  Fly  1095 EVGRRVAQHPFTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTN 1159
            ..|.:|.        |....||..........||..:.|.|::.:|..|..........|..||.
Mouse  3870 NEGDQVK--------NGTNMKSLNLEMQEPVIAASLSQTGASIGSALAAIMLLLLLFLVACFVTR 3926

  Fly  1160 PAAGDGISVQNDPPVDS-SGSPASPK--KGKANAD--------DYA-----------ESFRDFQC 1202
            ....   ..:..||.|: ...|.:.|  ..|.|||        .|.           |.:..|:.
Mouse  3927 KCQK---QKKKQPPEDTLEEYPLNTKVDVAKRNADKVEKNANRQYCTVRNVNILSDNEGYYTFKG 3988

  Fly  1203 SQIVKCELEMAEKIYNDV 1220
            :::.|..||:  :::|::
Mouse  3989 AKVKKLNLEV--RVHNNL 4004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	130/680 (19%)
		Peptidase_S8	331..600	CDD:278510	76/409 (19%)
		TPPII	892..1073	CDD:289357	40/207 (19%)
		TPPII_N	1144..1257	CDD:289360	19/99 (19%)
Fras1	NP_780682.3	VWC	27..86	CDD:214564
		VWC	94..151	CDD:278520
		VWC	158..215	CDD:278520
		VWC	220..277	CDD:278520
		VWC	284..341	CDD:302663
		VWC	368..415	CDD:302663
		FU 1	408..459
		GF_recep_IV	411..527	CDD:291509
		FU	420..>458	CDD:238021
		FU 2	461..504
		FU	461..503	CDD:214589
		FU 3	506..552
		FU	507..551	CDD:214589
		GF_recep_IV	511..623	CDD:291509
		FU 4	554..598
		FU	555..597	CDD:214589
		FU 5	601..646
		GF_recep_IV	606..728	CDD:291509
		FU	607..652	CDD:238021
		FU 6	648..704
		FU	649..703	CDD:214589
		FU 7	707..752
		FU	707..751	CDD:214589
		FU 8	754..799
		FU	754..798	CDD:214589
		Furin-like	759..912	CDD:279142
		FU 9	802..851
		FU	803..850	CDD:214589
		FU 10	853..899
		FU	853..898	CDD:214589
		FU 11	902..947
		Furin-like	905..1055	CDD:279142
		FU 12	951..996
		FU	951..995	CDD:214589
		FU 13	998..1041
		FU	1004..1048	CDD:238021
		Furin-like_2	1008..1098	CDD:292535
		FU 14	1045..1088
		FU	1045..1086	CDD:214589
		Cadherin_3	<1101..1197	CDD:292802
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1101..1196
		Cadherin_3	1167..1309	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1216..1307
		Cadherin_3	1278..1440	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1328..1440
		Cadherin_3	1411..1576	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1465..1561
		Cadherin_3	1531..1693	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1597..1691
		Cadherin_3	1662..1813	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1712..1812
		Cadherin_3	1780..1940	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1834..1938
		Cadherin_3	1906..2061	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1959..2059
		Cadherin_3	2030..2181	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2080..2179
		Cadherin_3	2149..2295	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2201..2293
		Cadherin_3	2263..2408	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2313..2406
		Cadherin_3	2377..2539	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2441..2538
		Calx-beta	2555..2648	CDD:295344	0/2 (0%)
Calx-beta	2673..2759	CDD:295344	27/112 (24%)
Calx-beta	2796..2892	CDD:295344	19/104 (18%)
Calx-beta	2918..3009	CDD:295344	22/92 (24%)
Calx-beta	3037..3131	CDD:295344	19/101 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900