DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and Tpp2

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_033444.1 Gene:Tpp2 / 22019 MGIID:102724 Length:1262 Species:Mus musculus


Alignment Length:1391 Identity:499/1391 - (35%)
Similarity:759/1391 - (54%) Gaps:166/1391 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 MATSGIVESFPTGALVPKAETGVLNFLQKYPEYDGRDVTIAIFDSGVDPRATGLETLCDGKTVKV 152
            |||:...|.||...|:||.|||..:||.:|||||||.|.||:.|:||||.|.|::...|||. |:
Mouse     1 MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKP-KI 64

  Fly   153 IERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMALNTDPEKAVRVGLKSFSDLLPSK 217
            |:..|.:|.|||:...:|.| ::|.|.||||..||:.    |..|:|.....:|:|:..|..|..
Mouse    65 IDIIDTTGSGDVNTATEVEP-KDGEIIGLSGRVLKIP----ANWTNPLGKYHIGIKNGYDFYPKA 124

  Fly   218 VRNNIVAQAKLKHWDKPHKTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEMLNSYE 282
            ::..|..:.|.|.||..|:.|.|.|.||..||:..|.|.:..    .|::||.|..::|:|||:|
Mouse   125 LKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQA----NKLIKEELQSQVELLNSFE 185

  Fly   283 KVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHE--TRNVDDFLSISVNVHD 345
            |.|.|....|||:::...:.|...||:.|.|||.:...:..|....|  :....:.|:.|||::|
Mouse   186 KKYSDPGPVYDCLVWHDGETWRACVDSNENGDLSKCAVLRNYKEAQEYSSFGTAEMLNYSVNIYD 250

  Fly   346 EGNVLEVVGMSSPHGTHVSSIASGNHSSR-DVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMT 409
            :||:|.:|.....|||||:|||:|:.... :.:||||.|:|:|:.|||.||.:|||||.|:|||.
Mouse   251 DGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMI 315

  Fly   410 KVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPPD 474
            :|:     ..:.|::|.||||..:|.|||||.|::||.|.|:..::|:||||:||.|.|||.|..
Mouse   316 EVI-----NHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGG 375

  Fly   475 ISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTM 539
            .:. |:|||||||||.||.|||::|||||.|.|||:||.|..||..||::.||||||||||.:|:
Mouse   376 TTS-SVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTL 439

  Fly   540 SKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGLLNV 604
            ..:||||||||::|:..|.:||::||||..|::|:.:|::||:..||.|...::.||||||::.|
Mouse   440 RGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQV 504

  Fly   605 EKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQ-RNSIDYNVYIEPIFYNDKEADPKDK 668
            :||:::|.:: .|..|.|.|:|.||||  :||:||..|| ....|:.|.|||:|  .:..:..:|
Mouse   505 DKAYDYLIQN-TSFANRLGFTVTVGNN--RGIYLRDPVQVAAPSDHGVGIEPVF--PENTENSEK 564

  Fly   669 FNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTDCVQKGSLFEI 733
            .:|.:.|.|.::..||||.:.|:|....|.|.:||||.||:.|:|...:..||......|.||.:
Mouse   565 ISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRV 629

  Fly   734 PVT-VVQPHVLESDQNTPVFEPASSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGE 797
            |:| |:...|.||......|        ..|.|:|..|:|.|:.|||.|||||:.:....   .|
Mouse   630 PITAVIAAKVNESSHYDLAF--------TDVHFKPGQIRRHFVEVPEGATWAEVTVCSCS---SE 683

  Fly   798 DIGKFFVHTNQLLPKQSCRKLETMKIVSVGSENESIMAFKVKSGRILELCIAKYWSNYGQSHLKY 862
            ...||.:|..||:.:::.|..|..|..|:..:...|.||.|..|:.:|.|||::|::....::.|
Mouse   684 VSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDY 748

  Fly   863 SLRFRGVEAHNPNAYVMHAGRGIHKLEIE-ALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRD 926
            ::.|.|:....|...: ||..||::.::: :|..||:.|.:.||:....|:|..||..|| .:||
Mouse   749 TISFHGIVCTAPQLNI-HASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPL-GSRD 811

  Fly   927 VIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSHT 991
            |:|:.||:|:.:|.::.:..|:.:|:...|:..:||||:||:||:|::||.||..:.:|||:.|.
Mouse   812 VLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQ 876

  Fly   992 SFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSSPL 1056
            ...||:||:||||||:|||:...|:::.:...:.|.:|::.|:||.:||::..::|.:|  ||.|
Mouse   877 YSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKK--SSSL 939

  Fly  1057 RLSTRV---LYIAPITQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQH-------------PF 1105
            .|..:.   .::..:..:::.|...|.  .:|:|:|...:.|:|::..|.             |.
Mouse   940 TLPPKYNQPFFVTSLPDDKIPKGAGPG--CYLAGSLTLSKTELGKKAGQSAAKRQGKFKKDVIPV 1002

  Fly  1106 TYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPAAGDGISVQN 1170
            .|.|.|...|                       ..||:|                          
Mouse  1003 HYYLIPPPTK-----------------------IKNGSK-------------------------- 1018

  Fly  1171 DPPVDSSGSPASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPKHLQANLLLI 1235
            |...||       :|.|...:::.|:.||.:...:.|.:   :..|||::...:|.:|...:..:
Mouse  1019 DKEKDS-------EKEKDLKEEFTEALRDLKIQWMTKLD---STDIYNELKETYPAYLPLYVARL 1073

  Fly  1236 QNIESNQLKSQLPLTFVNAQKTSPPEAGESADKQKEDQKKVRSALERIVKLADKVIQETDSEALL 1300
            ..:                            |.:||..|:    |..||..|:.||...|..||.
Mouse  1074 HQL----------------------------DAEKERMKR----LNEIVDAANAVISHIDQTALA 1106

  Fly  1301 SYYGLKNDTRADAAKIKTNMDKQKNTLIEALSKKGIAVAK----------LAVLDDCIKD----- 1350
            .|..:|.|.|.|||.||.:|||||:|||:||.:||.|:|.          .|..|...|:     
Mouse  1107 VYIAMKTDPRPDAATIKNDMDKQKSTLIDALCRKGCALADHLLHTQPHDGAAAGDAEAKEEEGES 1171

  Fly  1351 SLAEINELYTEIIKFVDANDSKAIQFALWHAYAHGHYGRMYKYVVKLIEEKRTRDHFVELAAING 1415
            ::..::|.|.|..|:.|..|:|.:.||..||..:..|||..|:..||:|||.|::::.....:..
Mouse  1172 TMESLSETYWETTKWTDLFDTKVLIFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMK 1236

  Fly  1416 ALGHEHIRTVINRMMITAFPSSFRLF 1441
            .||..|..:.....:...:|..:.:|
Mouse  1237 LLGWTHCASFTENWLPIMYPPDYCVF 1262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 225/490 (46%)
Peptidase_S8 331..600 CDD:278510 139/269 (52%)
TPPII 892..1073 CDD:289357 67/183 (37%)
TPPII_N 1144..1257 CDD:289360 15/112 (13%)
Tpp2NP_033444.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 14..489 CDD:173796 225/490 (46%)
Peptidase_S8 236..500 CDD:278510 139/269 (52%)
TPPII 777..960 CDD:289357 67/185 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1010..1030 9/75 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850317
Domainoid 1 1.000 407 1.000 Domainoid score I704
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2471
Inparanoid 1 1.050 807 1.000 Inparanoid score I487
Isobase 1 0.950 - 0 Normalized mean entropy S4793
OMA 1 1.010 - - QHG58290
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005779
OrthoInspector 1 1.000 - - oto94782
orthoMCL 1 0.900 - - OOG6_104037
Panther 1 1.100 - - LDO PTHR43806
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1540
SonicParanoid 1 1.000 - - X4170
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.740

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