DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and Pcsk6

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_035178.1 Gene:Pcsk6 / 18553 MGIID:102897 Length:959 Species:Mus musculus


Alignment Length:523 Identity:107/523 - (20%)
Similarity:171/523 - (32%) Gaps:132/523 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   332 NVDDFLSISVNVHD-EGNVLEVVGMSSPHGTH-VSSIASGNHSSRDVDGVAPNAKIVSMTIGDGR 394
            |.|.:.|..||.:| :.:........:.|||. ...:|:..::|..:.|:|.||||..:.:.|| 
Mouse   208 NYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDG- 271

  Fly   395 LGSMETGTALVRAMTKVMELCRDGRR---IDVINMSYGEHANWSNSGRIGELMNEVVNKYGV--- 453
                        .:|.|:|....|.|   ||:.:.|:|...:.......|.|..:.. :||:   
Mouse   272 ------------DVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAF-EYGIKKG 323

  Fly   454 --------VWVASAGNHGPALCT----VGTPPDISQPSLIGVGAYVSPQMME-------AEYAMR 499
                    ||.:..|......|:    ..:...||..|....|.  .|..:|       ..|:..
Mouse   324 RQGLGSIFVWASGNGGREGDHCSCDGYTNSIYTISVSSTTENGH--KPWYLEECASTLATTYSSG 386

  Fly   500 EKLPGNVYTWTSRDPCIDGGQGVTVCAP--GGAIA---------------------SVPQFTMSK 541
            ......:.|...|..|.||..|.:|.||  .|.||                     |.|....:.
Mouse   387 AFYERKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKAS 451

  Fly   542 SQLMNGTSMAAPHVAG-----AVALLISGLKQQNIEYSPYSIKRAISVTATKLGYVDPFAQGHGL 601
            ...:||......|:.|     |.||::...|     ::....:.....||.|.....|..|   :
Mouse   452 DWKVNGAGHKVSHLYGFGLVDAEALVLEARK-----WTAVPSQHVCVATADKRPRSIPIVQ---V 508

  Fly   602 LNVEKAFEHLTEHRQSK-----DNMLRFSVRVGNNADKGIHL-------RQGVQRNSIDYNVYIE 654
            |..........:|...:     ..::|.|:......|..|||       .|.:.:..:|      
Mouse   509 LRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLD------ 567

  Fly   655 PIFYNDKEAD----------PKDKFNFNVRLNLIASQ---PWVQCGAFLDLS---YGTRSIAVRV 703
              |.|:...:          .|.:..:.:.:..|.||   |..| |...:.|   |||.....|.
Mouse   568 --FSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQ-GKLKEWSLILYGTAEHPYRT 629

  Fly   704 DPTGLQPGVHSAVIRAYDTDCVQKGSLFEIPVTVVQPHVLESDQNTPVFEPASSKGDNSVEFQPN 768
            ..:      |.:..|..:....::    |.|....||...|:.::...:...|.:|      .||
Mouse   630 FSS------HQSRSRMLELSVPEQ----EPPKAAGQPPQAETPEDEEEYTAPSIQG------SPN 678

  Fly   769 TIQ 771
            |:|
Mouse   679 TLQ 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 67/311 (22%)
Peptidase_S8 331..600 CDD:278510 70/322 (22%)
TPPII 892..1073 CDD:289357
TPPII_N 1144..1257 CDD:289360
Pcsk6NP_035178.1 S8_pro-domain 65..141 CDD:293079
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 150..444 CDD:173789 55/251 (22%)
Peptidase_S8 186..469 CDD:278510 61/276 (22%)
P_proprotein 529..619 CDD:279782 18/98 (18%)
FU 685..737 CDD:238021
FU 733..779 CDD:214589
Furin-like_2 741..837 CDD:292535
FU 787..827 CDD:214589
FU 834..876 CDD:214589
PLAC 932..955 CDD:285849
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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