DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TppII and Pcsk5

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_001177412.1	Gene:	Pcsk5 / 18552	MGIID:	97515	Length:	1877	Species:	Mus musculus

Alignment Length:	614	Identity:	122/614 - (19%)
Similarity:	207/614 - (33%)	Gaps:	210/614 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 ASRKIVEFESQNPGEASKLPW-DKKILKENLDFELEMLNSYEKVYGDIK-----------TSYDC 294
            :||....|.|..|    |:.| .::::|:....:.::.::....:.|.|           .::.|
Mouse    88 SSRGTHSFISMEP----KVEWIQQQVVKKRTKRDYDLSHAQSTYFNDPKWPSMWYMHCSDNTHPC 148

  Fly   295 ILFPTADG-W------LTIVDTTEQGDLDQALRIGEYSRTHE--TRNVDDFLSISVNVHDEGNVL 350
            ......:| |      ..||.|.    ||..:     .|||.  .:|.|...|..||    ||.|
Mouse   149 QSDMNIEGAWKRGYTGKNIVVTI----LDDGI-----ERTHPDLMQNYDALASCDVN----GNDL 200

  Fly   351 EVV-----GMSSPHGTH-VSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMT 409
            :.:     ...:.|||. ...:|:..::|....|:|.||||..:.:.||.:..|
Mouse   201 DPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDM----------- 254

  Fly   410 KVMELCRDGRRIDVINMSYG-EHANWSNSGRIGELMNEVVNKYGVVWVASAGNHGPALCTVGTPP 473
                       ::..::||. :|                |:.|...|                .|
Mouse   255 -----------VEAKSVSYNPQH----------------VHIYSASW----------------GP 276

  Fly   474 DISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFT 538
            |....::.| .|.::.|..|....|..:..|:|:.|.|.    :||:....|:..|...|:  :|
Mouse   277 DDDGKTVDG-PAPLTRQAFENGVRMGRRGLGSVFVWASG----NGGRSKDHCSCDGYTNSI--YT 334

  Fly   539 MSKSQLM-------------------------------------------NGTSMAAPHVAGAVA 560
            :|.|...                                           .|||.:||..||.:|
Mouse   335 ISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIA 399

  Fly   561 LLISG---LKQQNIEYSPYSIKRAISVTA-----TKLGYVDPFAQGHGLLNVE----KAFEHLTE 613
            |.:..   |..:::::......||..:.|     ...|:......|.||::.|    :|.:..|.
Mouse   400 LALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTV 464

  Fly   614 HRQ-----SKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKFNFNV 673
            .:|     |.|..:: ::| .|:|.:.|:...|...|...:..|:|.:........|:
Mouse   465 PQQHVCVESTDRQIK-TIR-PNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPR------- 520

  Fly   674 RLNLIASQPWVQCGAFLDLSYGTRS--IAVRVDPTGLQP------------GVHSA---VIRAYD 721
            |.:|         ..:|....||||  :|.|:....::.            |..:|   |:..||
Mouse   521 RGDL---------AIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYD 576

  Fly   722 TDCVQK-----GSLFEIPV----TVVQPH 741
            |....:     |.|.|..:    |.|||:
Mouse   577 TPSQLRNFKTPGKLKEWSLVLYGTSVQPY 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	81/425 (19%)
		Peptidase_S8	331..600	CDD:278510	62/326 (19%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
Pcsk5	NP_001177412.1	S8_pro-domain	40..116	CDD:293079	8/31 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	128..422	CDD:173789	70/367 (19%)
		Peptidase_S8	164..447	CDD:278510	70/356 (20%)
		P_proprotein	507..597	CDD:279782	20/105 (19%)
		Cell attachment site. /evidence=ECO:0000255	521..523		1/1 (100%)
		FU 1	632..682
		FU	637..687	CDD:238021
		CRM (Cys-rich motif)	638..1753
		FU	690..739	CDD:238021
		Furin-like_2	695..786	CDD:292535
		FU	781..825	CDD:214589
		GF_recep_IV	786..906	CDD:291509
		FU	835..880	CDD:214589
		FU	885..928	CDD:214589
		FU	931..980	CDD:214589
		FU	1036..1078	CDD:214589
		Furin-like_2	1043..1130	CDD:292535
		FU	1128..1165	CDD:214589
		FU	1211..1256	CDD:238021
		Furin-like_2	1214..1305	CDD:292535
		FU	1301..1343	CDD:214589
		Furin-like_2	1357..1445	CDD:292535
		FU	1397..1446	CDD:238021
		FU	1491..1535	CDD:214589
		GF_recep_IV	1496..1611	CDD:291509
		FU	1546..1593	CDD:238021
		FU	1594..1644	CDD:238021
		GF_recep_IV	1595..1712	CDD:291509
		FU	1642..1684	CDD:214589
		FU	1694..1736	CDD:214589
		AC 1	1825..1844
		AC 2	1856..1877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900