Protein Alignment TppII and Pcsk4

DIOPT Version :9

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: XP_006513421.1
• Gene: Pcsk4 / 18551
• MGIID: 97514
• Length: 679
• Species: Mus musculus
• Alignment Length: 613
• Identity: 119/613 - (19%)
• Similarity: 184/613 - (30%)
• Gaps: 223/613 - (36%)

  Fly   202 AVRVGLKSFSDLLPS----KVRNNIVAQAKL-KHWDKPHKTATANASRKIVEFESQNPGEASKL- 260
            |.:.|..:...:.|.    .:|:..|||..| .||.  |: .......|:..||.|......|.
Mouse    50 ARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWG--HR-LRLKKDPKVRWFEQQTLRRRVKRS 111

  Fly   261 ------PWDKK--ILKENLDFELEMLNSY------------------EKVYGDIKTSYDCILFPT 299
                  ||..|  .:.:.:..:|.:|.::                  ||.:.|:..:||    |.
Mouse   112 LVVPTDPWFSKQWYMNKEIQQDLNILKAWNQGLTGRGVVISILDDGIEKDHPDLWANYD----PL 172

  Fly   300 ADGWLTIVDTTEQGDLDQALRIGEYSRTHETRNVDDFLSISVNVHDEGNVLEVVGMSSPHGT--- 361
            |.......|...|         ..|:...|.|                           |||
Mouse   173 ASYDFNDYDPDPQ---------PRYTPNDENR---------------------------HGTRCA 201

  Fly   362 -HVSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVME---LCRDGRRID 422
             .||:.|:......   |||.||:|..:.:.||             |:|.::|   |....:.|.
Mouse   202 GEVSATANNGFCGA---GVAFNARIGGVRMLDG-------------AITDIVEAQSLSLQPQHIH 250

  Fly   423 VINMSYGEHANWSNSGRIGELMNEVVNK--------YGVVWVASAGNHGPALCTVGTPPDISQPS 479
            :.:.|:|...:.......|.|..|...:        .|.:::.::||.|............:...
Mouse   251 IYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIH 315

  Fly   480 LIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSK--- 541
            .:.||:          ...:.::|     |.| :.|   ....|.....|.:.. ||...:.
Mouse   316 TLSVGS----------TTRQGRVP-----WYS-EAC---ASTFTTTFSSGVVTD-PQIVTTDLHH 360

  Fly   542 --SQLMNGTSMAAPHVAGAVALLISG---LKQQNIEYSPYSIKRAISVTAT--------KLGYVD 593
              :....|||.:||..||.:||.:..   |..:::::......|...:.|.        :.|.|.
Mouse   361 QCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQGAVG 425

  Fly   594 P---------------------FAQGHGLLN----VEKAFEHLTEHRQSKDNMLRFSVRVGNNAD 633
            |                     ...|:|||:    |:.|...|....|.|     .::||
Mouse   426 PGRGSGCGALRASDRYPSRAVSHHYGYGLLDAGLLVDLARVWLPTKPQKK-----CAIRV----- 480

  Fly   634 KGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKFNFNV-------RLNLIASQPWVQCGAFLD 691
              :|..              .||.       |:.....||       |..||.|...||  ..|.
Mouse   481 --VHTP--------------TPIL-------PRMLVPKNVTACSDGSRRRLIRSLEHVQ--VQLS 520

  Fly   692 LSY--------------GTRSIAVRVDP 705
            |||              ||||..|.:.|
Mouse   521 LSYSRRGDLEIFLTSPMGTRSTLVAIRP 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	83/449 (18%)
		Peptidase_S8	331..600	CDD:278510	55/320 (17%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
Pcsk4	XP_006513421.1	S8_pro-domain	34..110	CDD:374560	15/62 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	115..404	CDD:173789	65/364 (18%)
		P_proprotein	512..>577	CDD:366670	12/39 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900