Protein Alignment TppII and Furin

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: XP_011249120.1
• Gene: Furin / 18550
• MGIID: 97513
• Length: 803
• Species: Mus musculus
• Alignment Length: 917
• Identity: 174/917 - (18%)
• Similarity: 274/917 - (29%)
• Gaps: 328/917 - (35%)

  Fly   556 AGAVALLISGLKQQNIEYSPYSIK----RAISVTATKLGYVDPFAQGHGLLNVEKAF-------- 608
            ||||.||.:..:.|.|..:.:::.    .|::         |..||.||..|:.:.|
Mouse    14 AGAVVLLAADAQGQKIFTNTWAVHIPGGPAVA---------DRVAQKHGFHNLGQIFGDYYHFWH 69

  Fly   609 -----EHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPK-- 666
                 ..|:.||.....:.|        ..:...|.|.|.:.....:||.||       .|||
Mouse    70 RAVTKRSLSPHRPRHSRLQR--------EPQVKWLEQQVAKRRAKRDVYQEP-------TDPKFP 119

  Fly   667 --------DKFNFNVRLNLIASQPWVQCGAFLDLSYGTRSIAVRVDPTGLQPGVHSAVIRAYDTD 723
                    .:.:.||:      :.|.|       .:....|.|.:...|::.. |..:...||
Mouse   120 QQWYLSGVTQRDLNVK------EAWAQ-------GFTGHGIVVSILDDGIEKN-HPDLAGNYD-- 168

  Fly   724 CVQKGSLFEI------PVTVVQPHVLESDQN------------------------------TPVF 752
               .|:.|::      |    ||...:.:.|                              .|:|
Mouse   169 ---PGASFDVNDQDPDP----QPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGAPLF 226

  Fly   753 EPASSKG-------------DNSVEFQPNTIQRDFILVPERATWA----------------ELRM 788
            .|....|             ..|:...||.|.      ...|:|.                |...
Mouse   227 PPPLRPGVRMLDGEVTDAVEARSLGLNPNHIH------IYSASWGPEDDGKTVDGPARLAEEAFF 285

  Fly   789 RITDPNRGEDIGKFFVHT--NQLLPKQSCRKLETMKIVSVGSENESIMAFKVKS----GRI---L 844
            |.....|| .:|..||..  |......||         :......||....:.|    |.:   .
Mouse   286 RGVSQGRG-GLGSIFVWASGNGGREHDSC---------NCDGYTNSIYTLSISSATQFGNVPWYS 340

  Fly   845 ELC---IAKYWSNYGQSH---LKYSLRFRGVEAHNPNAYVMHAGRGIHKLEIEA---LVAEDVQP 900
            |.|   :|..:|:..|:.   :...||.:..|:|...:.......||..|.:||   |...|:|
Mouse   341 EACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQ- 404

  Fly   901 QLQLKNAEVVLKPTEAKISPLSATRDVIPDGRQVYQN----LLAFNLNVAKAADVSIYAP---IF 958
            .|.::.:    ||........ ||..|   ||:|..:    ||.....||.|.:.:..||   ..
Mouse   405 HLVVQTS----KPAHLNADDW-ATNGV---GRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCI 461

  Fly   959 NDLLYEAEFESQMWMLFDANKALVATGDAHSHTSFTKLDKGEYTIRLQVRHEKR-DL-------- 1014
            .::|.|.:   .:....:..||:.|.....:|  .|:|:  ....||.:.:.:| ||
Mouse   462 VEILVEPK---DIGKRLEVRKAVTACLGEPNH--ITRLE--HVQARLTLSYNRRGDLAIHLISPM 519

  Fly  1015 -----------------------------------------LEKISEANLVASFKLTSPLTLDFY 1038
                                                     :|..||||
Mouse   520 GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEAN---------------- 568

  Fly  1039 ENYNQCIVGGRKYVSSPLRLSTRVLY-IAPITQERLTKANLPAQCAWLSGNLVFPQDEVG----- 1097
             ||            ..|...|.||| .||   |.|:.....:.|..|:.:......|.|
Mouse   569 -NY------------GTLTKFTLVLYGTAP---EGLSTPPESSGCKTLTSSQACVVCEEGYSLHQ 617

  Fly  1098 RRVAQH-PFTYILNPAEKKSHTNGSSNGSSAAGSTATAAAVTTANGAKPKAPATPQAATSVTNPA 1161
            :...|| |..:|....:....|........|:..|...|:..|..|     || |....|..:.|
Mouse   618 KSCVQHCPPGFIPQVLDTHYSTENDVEIIRASVCTPCHASCATCQG-----PA-PTDCLSCPSHA 676

  Fly  1162 AGDGISVQNDPPVDSSGSPASPKKGKANADDYAESFRDFQCSQIVKCELEMAEKIYNDVVAAHPK 1226
            :.|        ||:.:.|..|....::.......:.|.         |:||..::... :|:|..
Mouse   677 SLD--------PVEQTCSRQSQSSRESRPQQQPPALRP---------EVEMEPRLQAG-LASHLP 723

  Fly  1227 HLQANL-------------LLIQNIESNQLKSQLPLTF---VNAQKTSPPEAGES---ADKQKED 1272
            .:.|.|             |.:........:.....|.   :.:.|..||||.:.   :|.::::
Mouse   724 EVLAGLSCLIIVLIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDE 788

  Fly  1273 QKKVRSA 1279
            .:..|:|
Mouse   789 GRGERTA 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	9/36 (25%)
		TPPII	892..1077	CDD:463636	49/245 (20%)
		TPPII_N	1144..1257	CDD:403697	20/128 (16%)
Furin	XP_011249120.1	S8_pro-domain	33..107	CDD:465126	15/90 (17%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	113..412	CDD:173789	62/349 (18%)
		P_proprotein	494..580	CDD:460225	15/116 (13%)
		FU	591..629	CDD:214589	7/37 (19%)
		FU	648..>685	CDD:214589	13/50 (26%)