DRSC/TRiP Functional Genomics Resources

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Protein Alignment TppII and Pcsk2

DIOPT Version :9

Sequence 1:NP_725252.1 Gene:TppII / 36444 FlyBaseID:FBgn0020370 Length:1441 Species:Drosophila melanogaster
Sequence 2:NP_032818.1 Gene:Pcsk2 / 18549 MGIID:97512 Length:637 Species:Mus musculus


Alignment Length:291 Identity:65/291 - (22%)
Similarity:105/291 - (36%) Gaps:95/291 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   359 HGT----HVSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVME---LCR 416
            |||    .||:.||.|...   .|||.|:|:..:.:.|...            ||.::|   :..
Mouse   207 HGTRCAGEVSAAASNNICG---VGVAYNSKVAGIRMLDQPF------------MTDIIEASSISH 256

  Fly   417 DGRRIDVINMSYGEHANWSNSGRIGEL----MNEVVNK----YGVVWVASAGNHGPALCTVGTPP 473
            ..:.||:.:.|:|...|........||    |.:.|||    .|.::|.::|:.       |:..
Mouse   257 MPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDG-------GSYD 314

  Fly   474 DISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWT-SRDPCIDGGQGVTV---CAPGGAIASV 534
            |.:      ...|.|..                  || |.:..|:.|:....   |:  ..:||.
Mouse   315 DCN------CDGYASSM------------------WTISINSAINDGRTALYDESCS--STLAST 353

  Fly   535 --------PQFTMSKSQLM-------NGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISV 584
                    |:..::.:.|.       :|||.|||..||..||.:    :.|::.:...::....:
Mouse   354 FSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALAL----EANLDLTWRDMQHLTVL 414

  Fly   585 TATKLGYVDPFAQ----GHGLLNVEKAFEHL 611
            |:.:....|...|    |.||     .|.||
Mouse   415 TSKRNQLHDEVHQWRRNGVGL-----EFNHL 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TppIINP_725252.1 Peptidases_S8_Tripeptidyl_Aminopeptidase_II 101..589 CDD:173796 57/263 (22%)
Peptidase_S8 331..600 CDD:278510 60/278 (22%)
TPPII 892..1073 CDD:289357
TPPII_N 1144..1257 CDD:289360
Pcsk2NP_032818.1 S8_pro-domain 32..108 CDD:293079
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 121..417 CDD:173789 57/261 (22%)
Peptidase_S8 157..434 CDD:278510 60/278 (22%)
P_proprotein 503..590 CDD:279782
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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