Protein Alignment TppII and Pcsk1

DIOPT Version :10

• Sequence 1: NP_725252.1
• Gene: TppII / 36444
• FlyBaseID: FBgn0020370
• Length: 1441
• Species: Drosophila melanogaster
• Sequence 2: NP_038656.1
• Gene: Pcsk1 / 18548
• MGIID: 97511
• Length: 753
• Species: Mus musculus
• Alignment Length: 827
• Identity: 158/827 - (19%)
• Similarity: 270/827 - (32%)
• Gaps: 280/827 - (33%)

  Fly   229 KHWDKP--------HKTATANASRKIVEFESQNPGEASKLPWDKKILKENLDFELEMLNS---YE 282
            ||...|        |.|...:...::...|.|...|.||....|       |..|::.|.   .:
Mouse    71 KHKSHPRRSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQK-------DSALDLFNDPMWNQ 128

  Fly   283 KVYGDIKTSYDCILFPTADGWLTIVDTTEQG---------DLDQALRIGEYSRTHETRNVD---- 334
            :.|  ::.:......|..|  |.::...|:|         .||..|   |::.|....|.|
Mouse   129 QWY--LQDTRMTAALPKLD--LHVIPVWEKGITGKGVVITVLDDGL---EWNHTDIYANYDPEAS 186

  Fly   335 -DFLSISVNVHDEGNVLEVVGMSSPHGTHVS---SIASGNHSSRDVDGVAPNAKIVSMTIGDGRL 395
             ||   :.|.||.....::.. .:.|||..:   ::.:.||...  .|||.|:|:..:.:.||
Mouse   187 YDF---NDNDHDPFPRYDLTN-ENKHGTRCAGEIAMQANNHKCG--VGVAYNSKVGGIRMLDG-- 243

  Fly   396 GSMETGTALVRAMTKVMELCRDG---RRIDVINMSYGEHANWSNSGRIGELMNEVVNKYGVVWVA 457
                       .:|..:|....|   ..:|:.:.|:|.    ::.|:
Mouse   244 -----------IVTDAIEASSIGFNPGHVDIYSASWGP----NDDGK------------------ 275

  Fly   458 SAGNHGPALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMRE--KLPGNVYTWTSRDPCIDGGQ 520
                      ||..|..::|.:.              ||.:::  :..|:::.|.|.    :||:
Mouse   276 ----------TVEGPGRLAQKAF--------------EYGVKQGRQGKGSIFVWASG----NGGR 312

  Fly   521 GVTVCAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNIEYSPYSIKRAISVT 585
            ....|...|...|:  :|:|                      ||...||.:  ||:..::..|..
Mouse   313 QGDNCDCDGYTDSI--YTIS----------------------ISSASQQGL--SPWYAEKCSSTL 351

  Fly   586 ATKLGYVDPFAQGHGLLNVEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYN 650
            ||.....|                 .|:.|.:..::................|..|:...:::.|
Mouse   352 ATSYSSGD-----------------YTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEAN 399

  Fly   651 VYI-----EPIFYNDKEADPKDKFNFNVRLNLIASQP-WVQCGAFLDLS----YG---TRSIAVR 702
            ..:     :.:.....|.||            :||.| |.:.||.|.::    :|   .:::...
Mouse   400 PNLTWRDMQHLVVWTSEYDP------------LASNPGWKKNGAGLMVNSRFGFGLLNAKALVDL 452

  Fly   703 VDPTGLQPGVHSAVIRAY-----DTDCVQKGSLF-------------EIPVTVV--QPHVLESDQ 747
            .||            |.:     ..:||.|.:.|             |||....  |.:.::|.:
Mouse   453 ADP------------RTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLE 505

  Fly   748 NTPVFEPA---SSKGDNSVEFQPNTIQRDFILVPERATWAELRMRITDPNRGEDIGKFFVHTNQL 809
            :.. ||..   |.:||..|.. .:.:....:|:.||.       |.|.||..::.....|||...
Mouse   506 HVQ-FEATIEYSRRGDLHVTL-TSAVGTSTVLLAERE-------RDTSPNGFKNWDFMSVHTWGE 561

  Fly   810 LPKQSCRKLETMKIVSVGS--ENESIMAFKVKSGRILELCIAKYWSNYGQSHLKYSLRFRGVEAH 872
            .|..:.    |:||..:..  :||         |||:...:..:.::....|:|
Mouse   562 NPVGTW----TLKITDMSGRMQNE---------GRIVNWKLILHGTSSQPEHMK----------- 602

  Fly   873 NPNAY-----VMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPTEAKISPLSATRDVIPDG- 931
            .|..|     |.:..||:.|:   ..|.|....|..|...  :|.|..:..|.:...||....|
Mouse   603 QPRVYTSYNTVQNDRRGVEKM---VNVVEKRPTQKSLNGN--LLVPKNSSSSNVEGRRDEQVQGT 662

  Fly   932 -RQVYQNLL--AFNLNV------AKAADVSIYAPIFNDLLYEAEFES 969
             .:....||  ||:.|.      .|:....:..|      ||:.:|:
Mouse   663 PSKAMLRLLQSAFSKNALSKQSPKKSPSAKLSIP------YESFYEA 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	76/392 (19%)
		TPPII	892..1077	CDD:463636	20/88 (23%)
		TPPII_N	1144..1257	CDD:403697
Pcsk1	NP_038656.1	S8_pro-domain	34..110	CDD:465126	9/38 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	69/412 (17%)
		P_proprotein	504..591	CDD:460225	25/108 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..663		8/31 (26%)
		Proho_convert	713..751	CDD:463483