DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TppII and Pcsk4

DIOPT Version :9

Sequence 1:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster
Sequence 2:	NP_598243.1	Gene:	Pcsk4 / 171085	RGDID:	620325	Length:	654	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	136/710 - (19%)
Similarity:	208/710 - (29%)	Gaps:	268/710 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 AVRVGLKSFSDLLPS----KVRNNIVAQAKL-KHWDKPHKTATANASRKIVEFESQNPGEASKL- 260
            |.:.|..:...:.|.    .:|:..|||..| .||.  |: .......|:..||.|......|.
  Rat    50 ARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWG--HR-LRLKKEPKVRWFEQQTLRRRVKRS 111

  Fly   261 ------PWDKK--ILKENLDFELEML------------------NSYEKVYGDIKTSYDCILFPT 299
                  ||..|  .:.:.::.:|.:|                  :..||.:.|:..:||    |.
  Rat   112 LVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYD----PL 172

  Fly   300 ADGWLTIVDTTEQGDLDQALRIGEYSRTHETRNVDDFLSISVNVHDEGNVLEVVGMSSPHGT--- 361
            |.......|...|         ..|:...|.|                           |||
  Rat   173 ASYDFNDYDPDPQ---------PRYTPNDENR---------------------------HGTRCA 201

  Fly   362 -HVSSIASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALVRAMTKVME---LCRDGRRID 422
             .||:.|:......   |||.||:|..:.:.||             |:|.::|   |....:.|.
  Rat   202 GEVSATANNGFCGA---GVAFNARIGGVRMLDG-------------AITDIVEAQSLSLQPQHIH 250

  Fly   423 VINMSYGEHANWSNSGRIGELMNEVVNK--------YGVVWVASAGNHGPALCTVGTPPDISQPS 479
            :.:.|:|...:.......|.|..|...:        .|.:::.::||.|............:...
  Rat   251 IYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIH 315

  Fly   480 LIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPCIDGGQGVTVCAPGGAIASVPQFTMSK--- 541
            .:.||:          ...:.::|     |.| :.|   ....|.....|.:.. ||...:.
  Rat   316 TLSVGS----------TTRQGRVP-----WYS-EAC---ASTFTTTFSSGVVTD-PQIVTTDLHH 360

  Fly   542 --SQLMNGTSMAAPHVAGAVALLISG---LKQQNIEYSPYSIKRAISVTA-----TKLGYVDPFA 596
              :....|||.:||..||.:||.:..   |..:::::......|...:.|     ..:|......
  Rat   361 QCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHH 425

  Fly   597 QGHGLLN----VEKAFEHLTEHRQSKDNMLRFSVRVGNNADKGIHLRQGVQRNSIDYNVYIEPIF 657
            .|:|||:    |:.|...|....|.|     .::||       :|..              .||.
  Rat   426 YGYGLLDAGLLVDLARVWLPTKPQKK-----CTIRV-------VHTP--------------TPIL 464

  Fly   658 YNDKEADPKDKFNFNV-----RLNLIASQPWVQCGAFLDLSY--------------GTRSIAVRV 703
              .:...||   |..|     |..||.|...||  ..|.|||              ||||..|.:
  Rat   465 --PRMLVPK---NVTVCCDGSRRRLIRSLEHVQ--VQLSLSYSRRGDLEIFLTSPMGTRSTLVAI 522

  Fly   704 -----------------------DPTGL------------QPG-VHSAVIRAYD----------- 721
                                   ||.||            ..| ::...:..|.
  Rat   523 RPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQT 587

  Fly   722 ---TDCVQ---KGSLFEIP--------------------VTVVQPHVLESDQNTPVFEPA 755
               |.|..   :|....:|                    |..:|||...|||.|....|:
  Rat   588 PQVTSCAHACAEGHRGAVPGKSLSPLHCGRTLPHLQQAVVVALQPHTAASDQGTGQLSPS 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	83/446 (19%)
		Peptidase_S8	331..600	CDD:278510	53/296 (18%)
		TPPII	892..1073	CDD:289357
		TPPII_N	1144..1257	CDD:289360
Pcsk4	NP_598243.1	S8_pro-domain	34..110	CDD:293079	15/62 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	115..404	CDD:173789	65/364 (18%)
		Peptidase_S8	146..419	CDD:278510	62/348 (18%)
		P_proprotein	488..567	CDD:279782	16/80 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900